AIDS-Related Plasmablastic Lymphoma

  • Paul G. RubinsteinEmail author
  • Christoph Wyen


In 1997 a new entity was added to the World Health Organization (WHO) classification of lymphomas as a subset of diffuse large B cell lymphoma (DLBCL) called plasmablastic lymphoma (PBL). Its classification was prompted by its plasmacytoid appearance, with an elevated proliferation index, post-germinal phenotype with loss of the mature B cell markers, CD20, and strong expression of mature plasma cell antigens, i.e., CD138. The initial description was that this lymphoma affects primarily mucosal sites, particularly the oropharynx, and is characterized by poor outcome and is present predominantly in patients infected with HIV, though cases have also been reported in patients with advanced age or poor immune function. Here we examine the epidemiology, pathogenesis, diagnosis, and treatments for PBL and future directions to gain insight on how to better understand and manage this entity in patients infected with HIV.


Overall Survival Chronic Lymphocytic Leukemia Burkitt Lymphoma Oncogenic Virus Plasma Cell Myeloma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Section of Hematology/Oncology, Department of MedicineJohn H. Stroger Jr. Hospital of Cook County (Cook County Hospital)ChicagoUSA
  2. 2.Rush University Medical CenterChicagoUSA
  3. 3.The Ruth M. Rothstein CORE CenterChicagoUSA
  4. 4.First Department of Internal MedicineUniversity of CologneCologneGermany

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