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Burkitt Lymphoma

  • Silvia MontotoEmail author
  • Ariela Noy
  • Josep M. Ribera
Chapter

Abstract

Burkitt lymphoma was first described by Dennis Burkitt in 1958 in the paper entitled ‘A sarcoma involving the jaws of African children’, following his observation of several children with multiple jaw tumours in Uganda, where he was working as a surgeon for the British government. These small round cell tumours were later recognised to be lymphomas. Burkitt defined a geographic ‘lymphoma belt’ with a high incidence of BL. The ‘lymphoma belt’ corresponds closely to the distribution of several insect-transmitted diseases leading to the hypothesis that BL might be driven by a virus. When MA Epstein, a pathologist with a special interest in virology, obtained tumour samples from Burkitt, he was able to demonstrate the presence of herpes-like particles in the tumours. The epidemiological and pathogenic relationship between the newly described Epstein-Barr virus (EBV) and African cases of BL was further demonstrated in several studies. In parallel, the observation that the ‘lymphoma belt’ mimicked the distribution of malaria and that successful malaria-eradication campaigns resulted in a decreased incidence of BL supported a role for malaria in the pathogenesis of BL, possibly by causing hyperplasia of B-lymphocytes and an increase in the circulation of EBV-infected memory B-cells. Whereas it is clear that both EBV and malaria play a significant role in the development of BL, the exact mechanism is still not well understood.

Keywords

Primary Central Nervous System Lymphoma Central Nervous System Involvement Burkitt Lymphoma Immunocompetent Patient Central Nervous System Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Burkitt D. A sarcoma involving the jaws in African children. Br J Surg. 1958;46(197):218–23.CrossRefPubMedGoogle Scholar
  2. 2.
    Magrath I. Denis Burkitt and the African lymphoma. Ecancermedicalscience. 2009;3:159.PubMedCentralPubMedGoogle Scholar
  3. 3.
    Brady G, MacArthur GJ, Farrell PJ. Epstein-Barr virus and Burkitt lymphoma. J Clin Pathol. 2007;60(12):1397–402.PubMedCentralPubMedGoogle Scholar
  4. 4.
    Gibson TM, Morton LM, Shiels MS, Clarke CA, Engels EA. Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era: a population-based study. AIDS. 2014;28(15):2313–8.PubMedCentralCrossRefPubMedGoogle Scholar
  5. 5.
    International Collaboration on HIV and Cancer. Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virus-infected adults. J Natl Cancer Inst. 2000;92(22):1823–30.CrossRefGoogle Scholar
  6. 6.
    Wang ES, Straus DJ, Teruya-Feldstein J, et al. Intensive chemotherapy with cyclophosphamide, doxorubicin, high-dose methotrexate/ifosfamide, etoposide, and high-dose cytarabine (CODOX-M/IVAC) for human immunodeficiency virus-associated Burkitt lymphoma. Cancer. 2003;98(6):1196–205.CrossRefPubMedGoogle Scholar
  7. 7.
    Ribera JM, Garcia O, Grande C, et al. Dose-intensive chemotherapy including rituximab in Burkitt’s leukemia or lymphoma regardless of human immunodeficiency virus infection status: final results of a phase 2 study (Burkimab). Cancer. 2013;119(9):1660–8.CrossRefPubMedGoogle Scholar
  8. 8.
    Dunleavy K, Pittaluga S, Shovlin M, et al. Low-intensity therapy in adults with Burkitt’s lymphoma. N Engl J Med. 2013;369(20):1915–25.PubMedCentralCrossRefPubMedGoogle Scholar
  9. 9.
    Cortes J, Thomas D, Rios A, et al. Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone and highly active antiretroviral therapy for patients with acquired immunodeficiency syndrome-related Burkitt lymphoma/leukemia. Cancer. 2002;94(5):1492–9.CrossRefPubMedGoogle Scholar
  10. 10.
    Lim ST, Karim R, Nathwani BN, Tulpule A, Espina B, Levine AM. AIDS-related Burkitt’s lymphoma versus diffuse large-cell lymphoma in the pre-highly active antiretroviral therapy (HAART) and HAART eras: significant differences in survival with standard chemotherapy. J Clin Oncol. 2005;23(19):4430–8.CrossRefPubMedGoogle Scholar
  11. 11.
    Murphy SB, Bowman WP, Abromowitch M, et al. Results of treatment of advanced-stage Burkitt’s lymphoma and B cell (SIg+) acute lymphoblastic leukemia with high-dose fractionated cyclophosphamide and coordinated high-dose methotrexate and cytarabine. J Clin Oncol. 1986;4(12):1732–9.PubMedGoogle Scholar
  12. 12.
    Magrath I, Adde M, Shad A, et al. Adults and children with small non-cleaved-cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen. J Clin Oncol. 1996;14(3):925–34.PubMedGoogle Scholar
  13. 13.
    Spina M, Jaeger U, Sparano JA, et al. Rituximab plus infusional cyclophosphamide, doxorubicin, and etoposide in HIV-associated non-Hodgkin lymphoma: pooled results from 3 phase 2 trials. Blood. 2005;105(5):1891–7.CrossRefPubMedGoogle Scholar
  14. 14.
    Montoto S, Wilson J, Shaw K, et al. Excellent immunological recovery following CODOX-M/IVAC, an effective intensive chemotherapy for HIV-associated Burkitt’s lymphoma. AIDS. 2010;24(6):851–6.CrossRefPubMedGoogle Scholar
  15. 15.
    Hoelzer D, Walewski J, Dohner H, et al. Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial. Blood. 2014;124(26):3870–9.PubMedCentralCrossRefPubMedGoogle Scholar
  16. 16.
    Evens AM, Carson KR, Kolesar J, et al. A multicenter phase II study incorporating high-dose rituximab and liposomal doxorubicin into the CODOX-M/IVAC regimen for untreated Burkitt’s lymphoma. Ann Oncol. 2013;24(12):3076–81.PubMedCentralCrossRefPubMedGoogle Scholar
  17. 17.
    Little RF, Pittaluga S, Grant N, et al. Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology. Blood. 2003;101(12):4653–9.CrossRefPubMedGoogle Scholar
  18. 18.
    Sparano JA, Lee S, Chen MG, et al. Phase II trial of infusional cyclophosphamide, doxorubicin, and etoposide in patients with HIV-associated non-Hodgkin’s lymphoma: an Eastern Cooperative Oncology Group Trial (E1494). J Clin Oncol. 2004;22(8):1491–500.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Haemato-oncology Department, St Bartholomew’s Hospital, Barts Cancer InstituteQueen Mary University of LondonLondonUK
  2. 2.Hematology Division, Lymphoma ServiceMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Clinical Hematology Service, IJC-Institut de Recerca Contra la Leucèmia Josep CarrerasUniversitat Autònoma de BarcelonaBadalonaSpain

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