HIV-Associated Multicentric Castleman’s Disease

  • Christian HoffmannEmail author
  • Eric Oksenhendler
  • Laurence Gérard


Multicentric Castleman’s disease (MCD) is a rare but potentially fatal lymphoproliferative disorder that shows a close association with human herpesvirus-8 (HHV-8) infection. Interleukin-6 dysregulation is thought to be fundamental to its pathogenesis. MCD is characterized by recurrent flares with fever, lymphadenopathy, splenomegaly, and heterogeneous systemic manifestations, associated with cytopenia, raised inflammatory markers, and high HHV-8 viral load in the blood. During the recent years, the widespread use of combination antiretroviral therapy and the introduction of rituximab have dramatically improved the treatment of HIV-MCD.


Primary Effusion Lymphoma Mantle Zone Polyclonal Hypergammaglobulinemia Intravenous Etoposide Lytic Viral Replication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Christian Hoffmann
    • 1
    Email author
  • Eric Oksenhendler
    • 2
  • Laurence Gérard
    • 2
  1. 1.Infektionsmedizinisches Centrum Hamburg (ICH)HamburgGermany
  2. 2.Hôpital Saint-Louis, AP-HP, and EA3963, University Paris DiderotParisFrance

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