Myeloproliferative Neoplasms

  • Ryan C. Fang
  • David M. AboulafiaEmail author


Human immunodeficiency virus (HIV) infection is linked to an increased risk of both acquired immunodeficiency syndrome (AIDS)-defining malignancies (ADMs) and non-AIDS-defining malignancies (nADMs). One subset of these nADMs are myeloproliferative neoplasms (MPNs), in which there is an overproduction of red blood cells (RBCs), platelets, or a subset of white blood cells (WBCs). Many patients with MPNs are asymptomatic at the time of medical evaluation, and their diagnosis is established after routine blood testing reveals an anomaly. Others present to medical attention complaining of headache, fatigue, weight loss, and early satiety in the backdrop of splenomegaly, bleeding, and thrombotic complications and clonal evolution.


Human Immunodeficiency Virus Chronic Myeloid Leukemia Human Immunodeficiency Virus Infection Polycythemia Vera Essential Thrombocythemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Section of Hematology and OncologyVirginia Mason Medical CenterSeattleUSA
  2. 2.Division of HematologyUniversity of WashingtonSeattleUSA

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