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HIV-associated Hematological Malignancies pp 145–151Cite as

Acute Lymphoblastic Leukemia

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Abstract

The term “non-AIDS-defining cancers” (NADCs) refers to neoplasms other than AIDS-defining malignancies that occur in individuals with HIV infection. The spectrum and incidence of various neoplasms reported among persons infected with human immunodeficiency virus (HIV) has increased, and this emerging problem has contributed to the mortality of HIV-infected persons in the current era of potent antiretroviral therapy (ART). Large, population-based studies involving registry match data have reported a wide range of cancers in association with HIV infection. Incidence of cancer among HIV-infected persons was compared with that of the general population from 1992 to 2003 in a prospective observational study conducted in the United States. However, investigators reported that the incidence of leukemia was only slightly higher in HIV-infected people (standardized incidence ratio, SIR: 2.5; 95 % CI: 1.6–3.8). Except for a higher frequency of mature B or Burkitt’s ALL in HIV-infected patients, the clinical and biologic characteristics of ALL are similar to those observed in non-immunocompromised patients. In the ART era, the treatment of ALL in HIV-positive patients should be identical to that given in non-immunosuppressed individuals.

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Funding

Supported in part by grants from the Red Temática de Investigación Cooperativa en Cáncer (RTICC, FEDER) (RD12/0036/0029); 2014 SGR225 (GRE) Generalitat de Catalunya; PI14/01971 from Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III; and Fundació Internacional Josep Carreras i Obra Social “la Caixa,” Spain.

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Authors and Affiliations

  1. Clinical Hematology Department, ICO-Hospital Germans Trias i Pujol, Jose Carreras Research Institute, Universitat Autònoma de Barcelona, Badalona, Spain

    Josep-Maria Ribera MD, PhD

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  1. Josep-Maria Ribera MD, PhD
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Correspondence to Josep-Maria Ribera MD, PhD .

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Editors and Affiliations

  1. Department of Hematology and Oncology, Red Cross Hospital, Uni of Munich, Munich, Germany

    Marcus Hentrich

  2. Dept. of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

    Stefan K. Barta

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Ribera, JM. (2016). Acute Lymphoblastic Leukemia. In: Hentrich, M., Barta, S. (eds) HIV-associated Hematological Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-319-26857-6_11

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  • DOI: https://doi.org/10.1007/978-3-319-26857-6_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26855-2

  • Online ISBN: 978-3-319-26857-6

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