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HIV Infection and Myelodysplastic Syndrome/Acute Myeloid Leukemia

  • Ryan C. Fang
  • David M. AboulafiaEmail author
Chapter

Abstract

In this chapter, the authors briefly review the frequency, diagnosis, and treatment of acute myeloid leukemia (AML) in the setting of human immunodeficiency virus (HIV) infection. AML is relatively rare in HIV-infected individuals and had been described exclusively in adults until the report of a pediatric case in 2009. There have been no clinical trials to inform decision making in this group, but case series and retrospective analyses suggest that standard AML induction and consolidation algorithms are appropriate, particularly in those with well-controlled HIV viremia and adequate immune reserves. New areas of endeavor include high-dose chemotherapy coupled to autologous and allogeneic stem cell transplantation. Advances in the field of “HIV cure research” also offer the opportunity to eradicate not only AML but also HIV infection through the use of CCR-5-deficient hematopoietic stem cells.

Keywords

Human Immunodeficiency Virus Acute Myeloid Leukemia Human Immunodeficiency Virus Infection Polycythemia Vera Pediatric Acute Myeloid Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Availablle at www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Accessed 11-29-2015.
  2. 2.
    Kaplan LD, et al. Low-dose compared with standard-dose m-BACOD chemotherapy for non-Hodgkin’s lymphoma associated with human immunodeficiency virus infection. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group. N Engl J Med. 1997;336(23):1641–8.CrossRefPubMedGoogle Scholar
  3. 3.
    Krishnan A. Stem cell transplantation in HIV-infected patients. Curr Opin HIV AIDS. 2009;4(1):11–5.PubMedCentralCrossRefPubMedGoogle Scholar
  4. 4.
    Evans MW, et al. Risk assessment in human immunodeficiency virus-associated acute myeloid leukemia. Leuk Lymphoma. 2012;53(4):660–4.CrossRefPubMedGoogle Scholar
  5. 5.
    Sutton L, et al. Acute myeloid leukaemia in human immunodeficiency virus-infected adults: epidemiology, treatment feasibility and outcome. Br J Haematol. 2001;112(4):900–8.CrossRefPubMedGoogle Scholar
  6. 6.
    Samji H, et al. Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada. PLoS One. 2013;8(12):e81355.PubMedCentralCrossRefPubMedGoogle Scholar
  7. 7.
    Wada N, et al. Cause-specific mortality among HIV-infected individuals, by CD4(+) cell count at HAART initiation, compared with HIV-uninfected individuals. AIDS. 2014;28(2):257–65.PubMedCentralCrossRefPubMedGoogle Scholar
  8. 8.
    Miller V, Hodder S. Beneficial impact of antiretroviral therapy on non-AIDS mortality. AIDS. 2014;28(2):273–4.CrossRefPubMedGoogle Scholar
  9. 9.
    Juliusson G, et al. Acute myeloid leukemia in the real world: why population-based registries are needed. Blood. 2012;119(17):3890–9.PubMedCentralCrossRefPubMedGoogle Scholar
  10. 10.
    Robbins HA, et al. Excess cancers among HIV-infected people in the United States. J Natl Cancer Inst. 2015;107(4):1–8.Google Scholar
  11. 11.
    Ibarrondo P, et al. HIV-related hematologic malignancies pre-HAART (highly active antiretroviral therapy) era and HAART era: experience in one centre. Haematologica. 2013;98(1):649–50.Google Scholar
  12. 12.
    Bennett JM, et al. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 1976;33(4):451–8.CrossRefPubMedGoogle Scholar
  13. 13.
    Frisch M, et al. Association of cancer with AIDS-related immunosuppression in adults. JAMA. 2001;285(13):1736–45.CrossRefPubMedGoogle Scholar
  14. 14.
    Grulich AE, et al. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet. 2007;370(9581):59–67.CrossRefPubMedGoogle Scholar
  15. 15.
    Hagiwara S, et al. Non-AIDS-defining hematological malignancies in HIV-infected patients: an epidemiological study in Japan. AIDS. 2013;27(2):279–83.CrossRefPubMedGoogle Scholar
  16. 16.
    Dy IA, et al. Treatment outcome of acute myeloid leukemia (AML) in HIV plus patients. J Clin Oncol. 2012;30(15):1884–91.Google Scholar
  17. 17.
    Tullu MS, et al. Acute myelogenous leukemia in a child with HIV infection. Eur J Pediatr. 2010;169(5):629–31.CrossRefPubMedGoogle Scholar
  18. 18.
    Mani D, Dorer RK, Aboulafia DM. Therapy-related acute myeloid leukemia following HIV-associated lymphoma. Clin Lymphoma Myeloma. 2009;9(4):316–9.CrossRefPubMedGoogle Scholar
  19. 19.
    Park DJ, Koeffler HP. Therapy-related myelodysplastic syndromes. Semin Hematol. 1996;33(3):256–73.PubMedGoogle Scholar
  20. 20.
    Brusamolino E, et al. The risk of acute leukemia in patients treated for Hodgkin’s disease is significantly higher aft [see bined modality programs than after chemotherapy alone and is correlated with the extent of radiotherapy and type and duration of chemotherapy: a case-control study. Haematologica. 1998;83(9):812–23.PubMedGoogle Scholar
  21. 21.
    Josting A, et al. Secondary myeloid leukemia and myelodysplastic syndromes in patients treated for Hodgkin’s disease: a report from the German Hodgkin’s Lymphoma Study Group. J Clin Oncol. 2003;21(18):3440–6.CrossRefPubMedGoogle Scholar
  22. 22.
    Armitage JO, et al. Treatment-related myelodysplasia and acute leukemia in non-Hodgkin’s lymphoma patients. J Clin Oncol. 2003;21(5):897–906.CrossRefPubMedGoogle Scholar
  23. 23.
    Katsarou O, et al. Myelodysplastic features in patients with long-term HIV infection and haemophilia. Haemophilia. 2001;7(1):47–52.CrossRefPubMedGoogle Scholar
  24. 24.
    Takahashi K, et al. Clinical and cytogenetic characteristics of myelodysplastic syndrome in patients with HIV infection. Leuk Res. 2012;36(11):1376–9.CrossRefPubMedGoogle Scholar
  25. 25.
    Aboulafia DM, et al. Acute myeloid leukemia in patients infected with HIV-1. AIDS. 2002;16(6):865–76.CrossRefPubMedGoogle Scholar
  26. 26.
    Nabil S, et al. Topoisomerase II inhibitor induced leukemia in a patient with AIDS. AIDS. 2001;15(3):421–3.CrossRefPubMedGoogle Scholar
  27. 27.
    Olalla J, et al. Acute myelocytic leukemia and human immunodeficiency virus infection. Am J Med. 2001;111(1):79.CrossRefPubMedGoogle Scholar
  28. 28.
    Kravcik S, et al. Causes of death of HIV-infected persons in Ottawa, Ontario, 1984–1995. Arch Intern Med. 1997;157(18):2069–73.CrossRefPubMedGoogle Scholar
  29. 29.
    Pagani C, et al. Acute leukemia and high-risk myelodysplastic syndromes in HIV-positive patients: a clinical study of the Rete Ematologica Lombarda. Haematologica. 2013;98(3):141.Google Scholar
  30. 30.
    Oka Y, et al. Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART. Int J Hematol. 2010;91(1):140–5.CrossRefPubMedGoogle Scholar
  31. 31.
    Sora F, et al. Highly active antiretroviral therapy and allogeneic CD34(+) peripheral blood progenitor cells transplantation in an HIV/HCV coinfected patient with acute myeloid leukemia. Exp Hematol. 2002;30(3):279–84.CrossRefPubMedGoogle Scholar
  32. 32.
    Hutter G, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360(7):692–8.CrossRefPubMedGoogle Scholar
  33. 33.
    Smiley ST, et al. Progress toward curing HIV infections with hematopoietic stem cell transplantation. Clin Infect Dis. 2015;60(2):292–7.PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Section of Hematology and OncologyVirginia Mason Medical CenterSeattleUSA
  2. 2.Division of Hematology, Virginia Mason Medical CenterUniversity of WashingtonSeattleUSA

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