Skip to main content

Introduction

Historically parathyroid localization was felt to be unnecessary and all one needed was a good surgeon. Recently there has been growing interest in parathyroid localization after biochemical confirmation of hyperparathyroidism. Preoperative localization is also very important in re-operative procedures for persistent disease and can be very helpful in the localization of ectopic parathyroid glands. This has been shown to lead to less morbidity, smaller scar, and shorter operative time. There are multiple localization modalities including traditional neck CT, 4-dimensional CT (4DCT), ultrasound (US), sestamibi nuclear medicine studies, and MRI. The majority of these have been discussed elsewhere in this book. This chapter deals primarily with ultrasound preoperative localization. Alcohol injection for the treatment of primary hyperparathyroidism is also addressed.

It is important to note that imaging studies should be used as an adjunct in the evaluation of primary hyperparathyroidism (PHPT). They should not be used for diagnostic purposes but should be employed only after a biochemical diagnosis has been achieved and other causes of hyperparathyroidism such as familial hypocalciuric hypercalcemia, vitamin-D deficiency, and renal insufficiency have been ruled out.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mohammadi A, Moloudi F, Ghasemi-rad M. The role of colour Doppler ultrasonography in the preoperative localization of parathyroid adenomas. Endocr J. 2012;59:375–82. Clinical Investigation; Level 2a.

    Article  PubMed  Google Scholar 

  2. Devcic Z, Jeffrey RB, Kamaya A, Desser TS. The elusive parathyroid adenoma: techniques for detection. Ultrasound Q. 2013;29:179–87. Clinical Review.

    Article  PubMed  Google Scholar 

  3. Ruda JM, Hollenbeak CS, Stack Jr BC. A systematic review of the diagnosis and treatment of primary hyperparathyroidism from 1995 to 2003. Otolaryngol Head Neck Surg. 2005;132:359–72. Clinical Review.

    Article  PubMed  Google Scholar 

  4. Hughes DT, Sorensen MJ, Miller BS, Cohen MS, Gauger PG. The biochemical severity of primary hyperparathyroidism correlates with the localization accuracy of sestamibi and surgeon-performed ultrasound. J Am Coll Surg. 2014;219:1010–9. Population Observational Study; Level 2a.

    Article  PubMed  Google Scholar 

  5. Gilat H, Cohen M, Feinmesser R, et al. Minimally invasive procedure for resection of a parathyroid adenoma: the role of preoperative high-resolution ultrasonography. J Clin Ultrasound. 2005;33:283–7. Observational Study; Level 3a.

    Article  PubMed  Google Scholar 

  6. Haber RS, Kim CK, Inabnet WB. Ultrasonography for preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism: comparison with (99m)technetium sestamibi scintigraphy. Clin Endocrinol (Oxf). 2002;57:241–9. Clinical Investigation; Level 3a.

    Article  Google Scholar 

  7. Powell AC, Alexander HR, Chang R, et al. Reoperation for parathyroid adenoma: a contemporary experience. Surgery. 2009;146:1144–55. Population/Observational Study; level 3a.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Alexandrides TK, Kouloubi K, Vagenakis AG, et al. The value of scintigraphy and ultrasonography in the preoperative localization of parathyroid glands in patients with primary hyperparathyroidism and concomitant thyroid disease. Hormones (Athens). 2006;5:42–51. Clinical Investigation; Level 3a.

    Article  Google Scholar 

  9. Noda S, Onoda N, Kashiwagi S, et al. Strategy of operative treatment of hyperparathyroidism using US scan and (99m)Tc-MIBI SPECT/CT. Endocr J. 2014;61:225–30. Population/Observational Study; Level 3a.

    Article  PubMed  Google Scholar 

  10. Andrade JS, Mangussi-Gomes JP, Rocha LA, et al. Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correlation with preoperative ultrasonography and Tc99m-Sestamibi scintigraphy. Braz J Otorhinolaryngol. 2014;80:29–34. Population/Observational Study; Level 3a.

    Article  PubMed  Google Scholar 

  11. Jaskowiak N, Norton JA, Alexander HR, et al. A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma. Ann Surg. 1996;224:308–20. discussion 320–1, Clinical Investigation; Level 3a.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Shen W, Duren M, Morita E, et al. Reoperation for persistent or recurrent primary hyperparathyroidism. Arch Surg. 1996;131:861–7. discussion 867–9, Population/Observational Study; Level 3a.

    Article  CAS  PubMed  Google Scholar 

  13. Sukan A, Reyhan M, Aydin M, et al. Preoperative evaluation of hyperparathyroidism: the role of dual-phase parathyroid scintigraphy and ultrasound imaging. Ann Nucl Med. 2008;22:123–31. Clinical Investigation; Level 3a.

    Article  PubMed  Google Scholar 

  14. Kunstman JW, Kirsch JD, Mahajan A, Udelsman R. Clinical review: parathyroid localization and implications for clinical management. J Clin Endocrinol Metab. 2013;98:902–12. Clinical Review.

    Article  CAS  PubMed  Google Scholar 

  15. Barbaros U, Erbil Y, Salmashoglu A, et al. The characteristics of concomitant thyroid nodules cause false-positive ultrasonography results in primary hyperparathyroidism. Am J Otolaryngol. 2009;30:239–43. Clinical Investigation; Level 3a.

    Article  PubMed  Google Scholar 

  16. Vulpio C, Bossola M, De Gaetano A, et al. Usefulness of the combination of ultrasonography and 99mTc-sestamibi scintigraphy in the preoperative evaluation of uremic secondary hyperparathyroidism. Head Neck. 2010;32:1226–35. Clinical Investigation; Level 3a.

    Article  PubMed  Google Scholar 

  17. Barczynski M, Golkowski F, Konturek A, et al. Technetium-99m-sestamibi subtraction scintigraphy vs. ultrasonography combined with a rapid parathyroid hormone assay in parathyroid aspirates in preoperative localization of parathyroid adenomas and in directing surgical approach. Clin Endocrinol (Oxf). 2006;65:106–13. Clinical Investigation; Level 2a.

    Article  Google Scholar 

  18. Solorzano CC, Carneiro-Pla DM, Irvin 3rd GL. Surgeon-performed ultrasonography as the initial and only localizing study in sporadic primary hyperparathyroidism. J Am Coll Surg. 2006;202:18–24. Clinical Investigation; Level 3a.

    Article  PubMed  Google Scholar 

  19. Akinci B, Demir T, Yener S, et al. Beneficial effect of endocrinologist-performed ultrasonography on preoperative parathyroid adenoma localization. Endocr Pract. 2009;15:17–23. Clinical Investigation; Level 3a.

    Article  PubMed  Google Scholar 

  20. Dwarakanathan R, Maracir S, Chin SL. Percutaneous fine-needle ethanol injection in a renal transplant patient with enlarged parathyroid glands. Transplant Proc. 2000;32:1850–1. Level 4.

    Article  CAS  PubMed  Google Scholar 

  21. Fassi J, Lambertini R, Farias P, et al. Treatment of uremic hyperparathyroidism with percutaneous ethanol injection. Nephron Clin Pract. 2005;101:c53–7. Level 4.

    Article  CAS  PubMed  Google Scholar 

  22. Fukagawa M, Kitaoka M, Tominaga Y, Akizawa T, Kurokawa K. Selective percutaneous ethanol injection therapy (PEIT) of the parathyroid in chronic dialysis patients–the Japanese strategy. Japanese Working Group on PEIT of Parathyroid, Tokyo, Japan. Nephrol Dial Transplant. 1999;14:2574–7. Clinical Investigation; Level 3a.

    Article  CAS  PubMed  Google Scholar 

  23. Koiwa F, Kakuta T, Tanaka R, Yumita S. Efficacy of percutaneous ethanol injection therapy (PEIT) is related to the number of parathyroid glands in haemodialysis patients with secondary hyperparathyroidism. Nephrol Dial Transplant. 2007;22:522–8. Clinical Investigation; Level 2a.

    Article  CAS  PubMed  Google Scholar 

  24. Solbiati L, Giangrande A, De Pra L, et al. Percutaneous ethanol injection of parathyroid tumors under US guidance: treatment for secondary hyperparathyroidism. Radiology. 1985;155:607–10. Level 4.

    Article  CAS  PubMed  Google Scholar 

  25. Karstrup S, Hegedus L, Holm HH. Acute change in parathyroid function in primary hyperparathyroidism following ultrasonically guided ethanol injection into solitary parathyroid adenomas. Acta Endocrinol (Copenh). 1993;129:377–80. Level 4.

    CAS  Google Scholar 

  26. Fletcher S, Kanagasundaram NS, Rayner HC, et al. Assessment of ultrasound guided percutaneous ethanol injection and parathyroidectomy in patients with tertiary hyperparathyroidism. Nephrol Dial Transplant. 1998;13:3111–7. Clinical Investigation; Level 3a.

    Article  CAS  PubMed  Google Scholar 

  27. Cercueil JP, Jacob D, Verges B, et al. Percutaneous ethanol injection into parathyroid adenomas: mid- and long-term results. Eur Radiol. 1998;8:1565–9. Clinical Investigation; Level 3a.

    Article  CAS  PubMed  Google Scholar 

  28. Singh Ospina N, Thompson GB, Lee RA, Reading CC, Young Jr WF. Safety and efficacy of percutaneous parathyroid ethanol ablation in patients with recurrent primary hyperparathyroidism and multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 2015;100:E87–90. Clinical Investigation; Level 3a.

    Article  PubMed  Google Scholar 

  29. Verges BL, Cercueil JP, Jacob D, et al. Results of ultrasonically guided percutaneous ethanol injection into parathyroid adenomas in primary hyperparathyroidism. Acta Endocrinol (Copenh). 1993;129:381–7. Level 4.

    CAS  Google Scholar 

  30. Harman CR, Grant CS, Hay ID, et al. Indications, technique, and efficacy of alcohol injection of enlarged parathyroid glands in patients with primary hyperparathyroidism. Surgery. 1998;124:1011–9. discussion 1019–20, Clinical Investigation; Level 3a.

    Article  CAS  PubMed  Google Scholar 

  31. Kovatcheva RD, Vlahov JD, Shinkov AD, et al. High-intensity focused ultrasound to treat primary hyperparathyroidism: a feasibility study in four patients. AJR Am J Roentgenol. 2010;195:830–5. Level 4.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Donald L. Bodenner M.D., Ph.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Bodenner, D.L. (2017). Ultrasound. In: Stack, Jr., B., Bodenner, D. (eds) Medical and Surgical Treatment of Parathyroid Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-26794-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-26794-4_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26792-0

  • Online ISBN: 978-3-319-26794-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics