Abstract
Brachytherapy for thoracic malignancies provides localized intrathoracic delivery of high-dose targeted radiotherapy, which can be very potent as a primary treatment, an adjuvant treatment, or a salvage treatment. We present our experience, data, and recommendations in this regard.
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References
American Cancer Society (2015) Cancer facts & figures 2015. American Cancer Society, Atlanta
Brambilla E, Travis WD (2014) Lung cancer. In: Stewart BW, Wild CP (eds) World cancer report. World Health Organization, Lyon
Alberg AJ, Samet JM (2003) Epidemiology of lung cancer. Chest 123(1 Suppl):21S
Goldstraw P, Crowley J, Chansky K et al (2007) The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2(8):694
Arriagada R, Bergman B, Dunant A et al (2004) Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 350:351
Pignon JP, Tribodet H, Scagliotti GV et al (2008) Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J Clin Oncol 26:3552
Strauss GM, Herndon JE 2nd, Maddaus MA et al (2008) Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups. J Clin Oncol 26:5043
Yankauer S (1922) Two cases of lung tumour treated bronchoscopically. NY Med J 21:741–742
Kernan JD, Cracovaner AJ (1929) Carcinoma of the lung. Arch Surg 18:315–325
Kernan JD (1933) Carcinoma of the lung and bronchus treatment with radon implantations and diathermy. Arch Otolaryngol 17(4):457–475
Pool JL (1961) Bronchoscopy in the treatment of lung cancer. Trans Am Bronchoesoph Assoc 41:128–136
Graham EA, Singer JJ (1933) Successful removal of an entire lung for carcinoma of the bronchus. JAMA 18(101):1371–1374
Henschke UK (1959) Interstitial implantation in the treatment of primary bronchogenic carcinoma. Am J Roentgenol Radium Ther Nucl Med 79:981–987
Hilaris B, Martini N (1988) The current state of intraoperative interstitial brachytherapy in lung cancer. Int J Radiat Oncol Biol Phys 15:1347–1354
Hilaris B, Liskow A, Bains M et al (1979) A new endobronchial implanter. Memorial Sloan Kettering Clin Bull 9(1):21–23
Mittal B, Matuschak C, Culpepper J (1984) Endobronchial interstitial brachytherapy using a bronchofiberscope with a flexible injector system. Radiology 152:219–220
Mittal B, Parsons J, Webster J et al (1986) Transbronchial radioactive implantation using a flexible injector system: an improved technique for endobronchial brachytherapy. Radiother Oncol 5:11–13
Mendiondo OA, Dillon M, Beach LJ (1983) Endobronchial brachytherapy in the treatment of recurrent bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 9(4):579–582
Seagren S, Harrell J, Horn R (1985) High dose rate intraluminal irradiation in recurrent endobronchial carcinoma. Chest 88:810–814
Speiser B, Spratling L (1990) Intermediate dose rate remote afterloading brachytherapy for intraluminal control of bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 18(6):1443–1448
Gaspar L (1998) Brachytherapy in lung cancer. J Surg Oncol 67:60–70
Lo TCM, Girshovich L, Healey GA et al (1995) Low dose rate versus high dose rate intraluminal brachytherapy for malignant endobronchial tumors. Radiother Oncol 35(3):193–197
Lo TC, Beamis JF, Villanueva AG et al (2001) Intraluminal brachytherapy for malignant endobronchial tumors: an update on low-dose rate versus high-dose rate radiation therapy. Clin Lung Cancer 3(1):65–68
Marsiglia H, Baldeyrou P, Lartigau E et al (2000) High-dose-rate brachytherapy as sole modality for early-stage endobronchial carcinoma. Int J Radiat Oncol Biol Phys 47(3):665–672
Van Limbergen E, Pötter R (2002) Chapter 26. Bronchus cancer. In: GEC ESTRO handbook of brachytherapy, 1st edn. ESTRO, Leuven: ACCO; pp 545–560
Rivard M, Coursey BM, DeWerd LA et al (2004) Update of AAPM TG no. 43 report: a revised AAPM protocol for brachytherapy dose calculations. Med Phys 31(3):633–674
Gerbaulet A, Pötter R, Mazeron JJ, Meertens H, Van Limbergen E. The GEC ESTRO handbook of brachytherapy. Copyright 2002 by The Authors and ESTRO Printed by ACCO, Leuven
Joslin CAF, Flynn A, Hall EJ (2001) Principles and practice of brachytherapy using remote afterloading systems, 1st edn. Oxford University Press Inc, New York
Gollins SW, Burt PA, Barber PV et al (1994) High dose rate intraluminal radiotherapy for carcinoma of the bronchus: outcome of treatment of 406 patients. Radiother Oncol 33:31–40
Gollins SW, Burt PA, Barber PV et al (1996) Long-term survival and symptom palliation in small primary bronchial carcinomas following treatment with intraluminal radiotherapy alone. Clin Oncol (R Coll Radiol) 8(4):239–246
Taulelle M, Chauvet B, Vincent P et al (1998) High dose rate endobronchial brachytherapy: results and complications in 189 patients. Eur Respir J 11:162–168
Hennequin C, Bleichner O, Tredaniel J et al (2007) Long-term results of endobronchial brachytherapy: a curative treatment? Int J Radiat Oncol Biol Phys 67(2):425–430
Aumount-Le Guilcher M, Prevost B et al (2011) High-dose-rate brachytherapy for non–small cell lung carcinoma: a retrospective study of 226 patients. Int J Radiat Oncol Biol Phys 79(4):1112–1116
Nag S, Kelly JF, Horton JL et al (2001) Brachytherapy for carcinoma of the lung. Oncology (Williston Park) 15(3):371–381
Aygun C, Weiner S, Scariato A et al (1992) Treatment of non-small cell lung cancer with external beam radiotherapy and high dose rate brachytherapy. Int J Radiat Oncol Biol Phys 23:127–132
Nori D, Allison R, Kaplan B et al (1993) High dose rate intraluminal irradiation in bronchogenic carcinoma* technique and results. Chest 104:1006–1011
Huber RM, Fischer R, Hautmann H et al (1997) Does additional brachytherapy improve the effect of external irradiation? A prospective, randomized study in central lung tumors. Int J Radiat Oncol Biol Phys 38:533–540
Anacak Y, Mogulkoc N, Ozkok S et al (2001) High dose rate endobronchial brachytherapy in combination with external beam radiotherapy for stage III non-small cell lung cancer. Lung Cancer 34:253–259
Langendijk H, Jong J, Tjwa M et al (2001) External irradiation versus external irradiation plus endobronchial brachytherapy in inoperable non-small cell lung cancer: a prospective randomized study. Radiother Oncol 58:257–268
Gejerman G, Mullokandov EA, Bagiella E et al (2002) Endobronchial brachytherapy and external-beam radiotherapy in patients with endobronchial obstruction and extrabronchial extension. Brachytherapy 1:204–210
Ozkok S, Karakoyun-Celik O, Goksel T et al (2008) High dose rate endobronchial brachytherapy in the management of lung cancer: response and toxicity evaluation in 158 patients. Lung Cancer 62:326–333
Rochet N, Hauswald H, Stoiber EM et al (2013) Primary radiotherapy with endobronchial high-dose-rate brachytherapy boost for inoperable lung cancer: long-term results. Tumori 99(2):183–190
Cotter GW, Herbert DE, Ellingwood KE et al (1991) Inoperable endobronchial obstructing lung carcinoma treated with combined endobronchial and external beam irradiation. South Med J 84(5):562–565
Skowronek J, Piorunek T, Kanikowski M et al (2013) Definitive high-dose-rate endobronchial brachytherapy of bronchial stump for lung cancer after surgery. Brachytherapy 12(6):560–566
Quantrill SJ, Burt PA, Barber PV et al (2000) Treatment of endobronchial metastases with intraluminal radiotherapy. Respir Med 94:369–372
Burt PA, O’Driscoll BR, Notley HM et al (1990) Intraluminal irradiation for the palliation of lung cancer with the high dose rate micro-Selectron. Thorax 45:765–768
Reveiz L, Rueda JR, Cardona AF. Palliative endobronchial brachytherapy for non-small cell lung cancer (Review). The Cochrane Library. 2012;(12):CD004284.
Delclos MR, Komaki R, Morice RC et al (1996) Endobronchial brachytherapy with high-dose-rate remote afterloading for recurrent endobronchial lesions. Radiology 201:279–282
Chang LL, Horvath J, Peyton W et al (1994) High dose rate afterloading intraluminal brachytherapy in malignant airway obstruction of lung cancer. Int J Radiat Oncol Biol Phys 28(3):589–596
Chella A, Ambrogi MC, Ribechini A et al (2000) Combined Nd-YAG laser: HDR brachytherapy versus Nd-YAG laser only in malignant central airway involvement: a prospective randomized study. Lung Cancer 27:169–175
Ung YC, Yu E, Falkson C et al (2006) The role of high-dose-rate brachytherapy in the palliation of symptoms in patients with non-small-cell lung cancer: a systematic review. Brachytherapy 5:189–202
Mallick I, Sharma SC, Behera D (2007) Endobronchial brachytherapy for symptom palliation in non-small cell lung cancer- analysis of symptom response, endoscopic improvement and quality of life. Lung Cancer 55:313–318
Bedwinek J, Petty A, Bruton C et al (1991) The use of high dose rate endobronchial brachytherapy to palliate symptomatic endobronchial recurrence of previously irradiated bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 22:23–30
Speiser BL, Spratling L (1993) Remote afterloading brachytherapy for the local control of endobronchial carcinoma. Int J Radiat Oncol Biol Phys 25:579–587
Pisch J, Villamena PC, Harvey JC et al (1993) High dose-rate endobronchial irradiation in malignant airway obstruction. Chest 104:721–725
Kohek PH, Pakisch B, Glanzer H (1994) Intraluminal irradiation in the treatment of malignant airway obstruction. Eur J Surg Oncol 20:674–680
Tredaniel J, Hennequin C, Zalcman G et al (1994) Prolonged survival after high-dose rate endobronchial radiation for malignant airway obstruction. Chest 105:767–772
Ofiara L, Roman T, Schwartzman K et al (1997) Local determinants of response to endobronchial high-dose rate brachytherapy in bronchogenic carcinoma. Chest 112:946–953
Escobar-Sacristan JA, Granda-Orive JI, Jimenez GT et al (2004) Endobronchial brachytherapy in the treatment of malignant lung tumours. Eur Respir J 24:348–352
Kubaszewsk M, Skowronek J, Chichel A et al (2008) The use of high dose rate endobronchial brachytherapy to palliate symptomatic recurrence of previously irradiated lung cancer. Neoplasma 55(3):239–245
Guarnaschelli JN, Jose BO (2010) Palliative high-dose–rate endobronchial brachytherapy for recurrent carcinoma: the University of Louisville experience. J Palliat Med 12(8):981–989
Santos RS, Raftopoulos Y, Keenan RJ et al (2004) Bronchoscopic palliation of primary lung cancer. Surg Endosc 18:931–936
Miller JL, Phillips TW (1990) Neodymium:YAG laser and brachytherapy in the management of inoperable bronchogenic carcinoma. Ann Thorac Surg 50:190–196
Shea JM, Allen RP, Tharratt RS et al (1993) Survival of patients undergoing Nd:YAG laser therapy compared with Nd:YAG laser therapy and brachytherapy for malignant airway disease. Chest 103:1028–1031
Freitag L, Ernst A, Thomas M et al (2004) Sequential photodynamic therapy (PDT) and high dose brachytherapy for endobronchial tumour control in patients with limited bronchogenic carcinoma. Thorax 59:790–793
Weinberg BD, Allison RR, Sibata C et al (2010) Results of combined photodynamic therapy (PDT) and high dose rate brachytherapy (HDR) in treatment of obstructive endobronchial non-small cell lung cancer (NSCLC). Photodiagnosis Photodyn Ther 7:50–58
Gauwitz M, Ellerbroek N, Komaki R et al (1991) High dose endobronchial irradiation in recurrent bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 23:397–400
Kelly JF, Delclos MR, Morice RC et al (2000) High-dose-rate endobronchial brachytherapy effectively palliates symptoms due to airway tumors: the 10-year M.D. Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys 48(3):697–702
Hennequin C, Tredaniel J, Chevret S et al (1998) Predictive factors for late toxicity after endobronchial brachytherapy: a multivariate analysis. Int J Radiat Biol Phys 42(1):21–27
Allen AM, Abdelrahman N, Silvern D et al (2012) Endobronchial brachytherapy provides excellent long-term control of recurrent granulation tissue after tracheal stenosis. Brachytherapy 11(4):322–326, Epub 2012 Feb 28
Brenner B, Kramer MR, Katz A et al (2003) High dose rate brachytherapy for nonmalignant airway obstruction* New treatment option. Chest 124:1605–1610
Halkos ME, Godette KD, Lawrence C et al (2003) High dose rate brachytherapy in the management of lung transplant airway stenosis. Ann Thorac Surg 76:381–384
Kennedy AS, Sonnett JR, Orens JB et al (2000) High dose rate brachytherapy to prevent recurrent benign hyperplasia in lung transplant bronchi: theoretical and clinical considerations. J Heart Lung Transplant 19:155–159
Kramer MR, Katz A, Yarmolovsky A et al (2001) Successful use of high dose rate brachytherapy for non-malignant bronchial obstruction. Thorax 56:415–416
Madu CN, Machuzak MS, Sterman DH et al (2006) High-dose-rate (Hdr) brachytherapy for the treatment of benign obstructive endobronchial granulation tissue. Int J Radiat Oncol Biol Phys 66(5):1450–1456
Meyer A, Warszawski-Baumann A, Baumann R et al (2012) HDR brachytherapy: an option for preventing nonmalignant obstruction in patients after lung transplantation. Strahlenther Onkol 188:1085–1090
Rahman NA, Fruchter O, Shitrit D et al (2010) Flexible bronchoscopic management of benign tracheal stenosis: long term follow-up of 115 patients. J Cardiothorac Surg 5:2
Serber W, Dzeda MF, Hoppe RT (1998) Radiation treatment of benign disease. In: Perez CA, Brady LW (eds) Principles and practice of radiation oncology. Lippincott-Raven Publishers, Philadelphia, pp 2170–2172
Tendulkar RD, Fleming PA, Reddy CA et al (2008) High-dose-rate endobronchial brachytherapy for recurrent airway obstruction from hyperplastic granulation tissue. Int J Radiat Oncol Biol Phys 70(3):701–706
Tscheikuna J, Disayabutr S, Kakanaporn C et al (2013) High dose rate endobronchial brachytherapy (HDR-EB) in recurrent benign complex tracheobronchial stenosis: experience in two cases. J Med Assoc Thai 96(Suppl 2):S252–S256
Nag S, Abitbol AA, Anderson LL et al (1993) Consensus guidelines for high-dose-rate remote brachytherapy in cervical, endometrial, and endobronchial tumors. Int J Radiat Oncol Biol Phys 27:1241–1244
Hilaris BS (1994) Lung brachytherapy: an overview and current indications. Curr Perspect Thorac Oncol 4:45–53
Hilaris BS, Martini N (1979) Interstitial brachytherapy in cancer of the lung: a 20 year experience. Int J Radiat Oncol Biol Phys 5:1951–1956
Hilaris BS, Nori D, Martini N (1987) Intraoperative radiotherapy in stage I and II lung cancer. Semin Surg Oncol 3:22–32
Armstrong JG, Fass DE, Bains M et al (1991) Paraspinal tumors: techniques and results of brachytherapy. Int J Radiat Oncol Biol Phys 20:787–790
Fernando HC, Landreneau R, Mandrekar S et al (2014) Impact of brachytherapy on local recurrence rates after sublobar resection: results from ACOSOG Z4032 (Alliance), a phase III randomized trial for high-risk operable non-small cell lung cancer. J Clin Oncol 32:2456–2462
Landreneau RJ, Sugarbaker DJ, Mack MJ et al (1997) Wedge resection versus lobectomy for stage I (T1-T2 N0 M0) non-small cell lung cancer. J Thorac Cardiovasc Surg 113:691–700
Martini N, Bains MS, Burt ME et al (1995) Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg 109:120–129
Miller JI, Hatcher CR (1987) Limited resection of bronchogenic carcinoma in the patient with marked impairment of pulmonary function. Ann Thorac Surg 44:340–343
Ginsberg RJ, Rubinstein LV (1995) Lobectomy versus limited resection for T1 N0 non-small cell cancer by the Lung Cancer Study Group. Ann Thorac Surg 60:615–623
Chen A, Galloway M, Landreneau R et al (1999) Intraoperative 125I brachytherapy for high-risk stage I non-small cell lung carcinoma. Int J Radiat Oncol Biol Phys 44(5):1057–1063
D’Amato TA, Galloway M, Szydlowski G et al (1998) Intraoperative brachytherapy following thoracoscopic wedge resection of stage I lung cancer. Chest 114(4):1112–1115
Lee W, Daly BD, DiPetrillo TA et al (2003) Limited resection for non-small cell lung cancer: observed local control with implantation of I-125 brachytherapy seeds. Ann Thorac Surg 75:237–242
Colonias A, Betler J, Trombetta M et al (2011) Mature follow-up for high-risk stage I non-small cell lung carcinoma treated with sublobar resection and intraoperative 125-I brachytherapy. Int J Radiat Oncol Biol Phys 79(1):105–109
McKenna RJ, Mahtabifard A, McKenna R et al (2008) Wedge resection and brachytherapy for lung cancer in patients with poor pulmonary function. Ann Thorac Surg 85(2):S733–S736
Parashar B, Port J, Arora S et al (2015) Analysis of stereotactic radiation vs. wedge resection vs. wedge resection plus Cesium-131 brachytherapy in early stage lung cancer. Brachytherapy 2015. pii: S1538-4721(15)00455-9. doi:10.1016/j.brachy.2015.04.001
Fernando HC, Landreneau R, Mandrekar S et al (2011) The impact of adjuvant brachytherapy with sublobar resection on pulmonary function and dyspnea in high-risk patients with operable disease: preliminary results from the American College of Surgeons Oncology Group Z4032 trial. J Thorac Cardiovasc Surg 142(3):554–562
Fernando HC, Landreneau R, Mandrekar S et al (2015) Analysis of longitudinal quality-of-life data in high-risk operable patients with lung cancer: Results from ACOSOG Z4032 (Alliance) multicenter randomized trial. J Thorac Cardiovasc Surg 149:718–726
Mutyala S, Stewart A, Khan A et al (2010) Permanent Iodine-125 interstitial planar seed brachytherapy for close or positive margins for thoracic malignancies. Int J Radiat Oncol Biol Phys 76(4):1114–1120
Jemal A, Bray F, Center MM et al (2011) Global cancer statistics. CA Cancer J Clin 61:69
Baquet CR, Commiskey P, Mack K et al (2005) Esophageal cancer epidemiology in blacks and whites: racial and gender disparities in incidence, mortality, survival rates and histology. J Natl Med Assoc 97:1471
Edge SB, Byrd DR, Compton CC et al (eds) (2010) American Joint Committee on cancer staging manual, 7th edn. Springer, New York
Tepper J, Krasna MJ, Niedzwiecki D et al (2008) Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781. J Clin Oncol 26:1086
Van Hagen P, Hulshof MC, van Lanschot JJ et al (2012) Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med 366(22):2074–2084
Walsh TN, Noonan N, Hollywood D et al (1996) A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 335:462
Harvey JC, Fleischman EH, Bellotti JE et al (1993) Intracavitary radiation in the treatment of advanced esophageal carcinoma: a comparison of high dose rate vs. low dose rate brachytherapy. J Surg Oncol 52:101–104
Tamaki T, Ishikawa H, Takahashi T et al (2012) Comparison of efficacy and safety of low-dose-rate vs. high-dose-rate intraluminal brachytherapy boost in patients with superficial esophageal cancer. Brachytherapy 11:130–136
Liu H, Wang Q, Wan X et al (2014) Californium-252 neutron brachytherapy combined with external beam radiotherapy for esophageal cancer: long-term treatment results. Brachytherapy 13:514–521
Gaspar LE, Nag S, Herskovic A et al (1997) American brachytherapy society consensus guidelines for brachytherapy of esophageal cancer. Int J Radiat Oncol Biol Phys 38(1):127–132
Hareyama M, Nishio M, Kagami Y et al (1992) Intracavitary brachytherapy combined with external beam irradiation for squamous cell carcinoma of the thoracic esophagus. Int J Radiat Oncol Biol Phys 24:235–240
Hishikawa Y, Kurisu K, Taniguchi M et al (1991) High-dose-rate intraluminal brachytherapy for esophageal cancer: 10 years’ experience in Hyogo College of Medicine. Radiother Oncol 21:107–114
Gaspar LE, Kocha WI, Barnett R et al (1993) Cancer of the esophagus: brachytherapy, external beam radiation and chemotherapy. Cancer J 6:196–200
Gaspar LE, Winter K, Kocha WI et al (2000) A phase I/II study of external beam radiation, brachytherapy and concurrent chemotherapy for patients with localized carcinoma of the esophagus (RTOG 9207): final report. Cancer 88(5):988–995
Sharma V, Agarwal J, Dinshaw K et al (2000) Late esophageal toxicity using a combination of external beam radiation, intraluminal brachytherapy and 5-fluorouracil infusion in carcinoma of the esophagus. Dis Esophagus 13:219–225
Yorozu A, Dotiya T, Oki Y (1999) High-dose-rate brachytherapy boost following concurrent chemoradiotherapy for esophageal carcinoma. Int J Radiat Oncol Biol Phys 45:271–275
Fabrini MG, Perrone F, DeLiguoro M et al (2010) A single-institutional brachytherapy experience in the management of esophageal cancer. Brachytherapy 9(2):185–191
Lin J (2013) T1 esophageal cancer; request an endoscopic mucosal resection (EMR) for in-depth review. J Thorac Dis 5(3):353–356
Manner H, May A, Pech O et al (2008) Early Barrett’s carcinoma with “low-risk” submucosal invasion: long-term results of endoscopic resection with a curative intent. Am J Gastroenterol 103:2589–2597
Manner H, Pech O, Heldmann Y et al (2013) Efficacy, safety, and long-term results of endoscopic treatment for early stage adenocarcinoma of the esophagus with low-risk sm1 invasion. Clin Gastroenterol Hepatol 11:630–635
Ishikawa H, Nonaka T, Sakurai H et al (2010) Usefulness of intraluminal brachytherapy combined with external beam radiation therapy for submucosal esophageal cancer: long-term follow-up results. Int J Radiat Oncol Biol Phys 76(2):452–459
Pasquier D, Mirabel X, Adenis A et al (2006) External beam radiation therapy followed by high-dose-rate brachytherapy for inoperable superficial esophageal carcinoma. Int J Radiat Oncol Biol Phys 65(5):1456–1461
Cooper JS, Guo MD, Herskovic A et al (1999) Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85–01). Radiation Therapy Oncology Group. JAMA 281(17):1623–1627
Sur RK, Singh DP, Sharma SC et al (1992) Radiation therapy of esophageal cancer: role of high dose rate brachytherapy. Int J Radiat Oncol Biol Phys 22:1043–1046
Yin WB (1990) Brachytherapy of carcinoma of the esophagus in China, 1970–1974 and 1982–1984. In: Martinez AA, Orton CG, Moulds RF (eds) Brachytherapy: HDR and LDR. Nucletron Corp, Columbia, pp 52–56
Kumar S, Dimri K, Khurana R et al (2007) A randomized trial of radiotherapy compared with cisplatin chemo-radiotherapy in patients with unresectable squamous cell cancer of the esophagus. Radiother Oncol 83:139–147
Muijs CT, Beukema JC, Mul VE et al (2012) External beam radiotherapy combined with intraluminal brachytherapy in esophageal carcinoma. Radiother Oncol 102:303–308
Vuong T, Szego P, David M et al (2005) The safety and usefulness of high-dose-rate endoluminal brachytherapy as a boost in the treatment of patients with esophageal cancer with external beam radiation with or without chemotherapy. Int J Radiat Oncol Biol Phys 63(3):758–764
Amdal CD, Jacobsen AB, Sandstad B et al (2013) Palliative brachytherapy with or without primary stent placement in patients with oesophageal cancer, a randomized phase III trial. Radiother Oncol 107(3):428–433
Grazziotin Reisner R, Reisner ML, Ferreira MA et al (2015) Measuring relief of dysphagia in locally advanced esophageal carcinoma patients submitted to high-dose-rate brachytherapy. Brachytherapy 14(1):84–90
Rupinski M, Zagorowicz E, Regula J et al (2011) Randomized comparison of three palliative regimens including brachytherapy, photodynamic therapy, and APC in patients with malignant dysphagia (CONSORT 1a)(Revides II). Am J Gastroenterol 106(9):1612–1620
Skowronek J, Piotrowski T, Zwierzchowski G (2004) Palliative treatment by high-dose-rate intraluminal brachytherapy in patients with advanced esophageal cancer. Brachytherapy 3(2):87–94
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Renz, P., Van Deusen, M., Landreneau, R.J., Colonias, A. (2016). Thoracic Brachytherapy. In: Montemaggi, P., Trombetta, M., Brady, L. (eds) Brachytherapy. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/978-3-319-26791-3_12
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