Local Treatments and Supportive Care

  • Salma Faghri de la FeldEmail author
  • Naveed Sami


While the primary treatment of autoimmune blistering diseases (ABD) has been systemic therapy, it is important to be aware of the value of several non-systemic treatments. Topical corticosteroids (both as monotherapy and adjuvant therapy), intra-lesional corticosteroids and corticosteroid elixirs can play an important role in treatment. In addition, non-steroidal treatments such as topical calcineurin inhibitors and non-steroidal elixirs have also been reported in treatment of ABD. Furthermore, it is important to be aware of exogenous factors contributing to ABD (including food and nutrition, iodine, poor oral hygiene and ultraviolet light). Treatment of ABD is not complete without consideration of infection control and vaccination guidelines. Systemic antihistamines are also helpful in controlling symptoms of pruritus. A variety of local treatment options have proven to be beneficial in mild as well as moderate and severe disease as an adjuvant. Patients should be constantly encouraged and reminded that these measures may help reduce the dosage and duration of their systemic treatments, and in some mild cases provide remission of the ABD.


Local treatments in autoimmune blistering diseases Adjuvant treatments in autoimmune blistering diseases Topical corticosteroids Intralesional corticosteroids Side effects of local corticosteroids Non-steroidal topical therapies Elixirs Infection control Vaccines Ultraviolet light Food and nutrition Antihistamines 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of DermatologyEmory University School of MedicineAtlantaUSA
  2. 2.Department of DermatologyUniversity of Alabama – BirminghamBirminghamUSA

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