Abstract
This chapter discusses the information content of rapid serial images acquired during the first circulation of a radiopharmaceutical following intravenous injection. There are five nuclear medicine studies that routinely include first circulation images. In four of these studies there are paired structures of interest, and in two of these four studies paired time-activity curves are generated from the symmetrical structures. An understanding of the information content of paired time-activity curves from a mathematical point of view informs the visual interpretation of both the first circulation images and any time-activity curves that might be generated. The paired time-activity curves are not routinely quantitated. Clinical examples are provided.
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Klingensmith, W.C. (2016). Blood Flow: First Circulation Time-Activity Curves. In: The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals - A Clinical Perspective. Springer, Cham. https://doi.org/10.1007/978-3-319-26704-3_6
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DOI: https://doi.org/10.1007/978-3-319-26704-3_6
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