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Thyroid Hormone and the Mammalian Auditory System

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Hearing and Hormones

Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 57))

Abstract

Thyroid hormone serves a key role in the development of the mammalian auditory system. Certain thyroid disorders in humans, such as those arising from iodine deficiency or mutations in the thyroid hormone receptor β (THRB) gene, are associated with hearing loss. Genetic analyses in rodent models of thyroid hormone receptors and other factors that mediate the tissue response to thyroid hormone have yielded insights into the underlying cellular mechanisms of action. The cochlea is a major site of action of thyroid hormone during later phases of development when cell types acquire their final form and the physiological properties that allow the onset of hearing. Other sites of action include the middle ear and central auditory pathways. Thyroid hormone coordinates tissue remodeling and late stage differentiation of diverse cell types as the auditory system attains functional status.

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Acknowledgements

This work was supported by the intramural research program at the National Institute of Diabetes and Digestive and Kidney Disorders at the National Institutes of Health.

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  1. Laboratory of Endocrinology and Receptor Biology, NIDDK, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA

    Douglas Forrest & Lily Ng

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  1. Douglas Forrest
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Correspondence to Douglas Forrest .

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  1. Cornell University, Dept of Neruobiology and Behavior, Ithaca, New York, USA

    Andrew H. Bass

  2. University of Washington, Department of Psychology, Seattle, Washington, USA

    Joseph A. Sisneros

  3. Department of Biology, College Park, University of Maryland, College Park, Maryland, USA

    Arthur N. Popper

  4. Marine Biological Laboratory, Woods Hole, Massachusetts, USA

    Richard R. Fay

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Forrest, D., Ng, L. (2016). Thyroid Hormone and the Mammalian Auditory System. In: Bass, A., Sisneros, J., Popper, A., Fay, R. (eds) Hearing and Hormones. Springer Handbook of Auditory Research, vol 57. Springer, Cham. https://doi.org/10.1007/978-3-319-26597-1_7

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