Abstract
This chapter is intended to provide practical instruction in further assessing core biopsy material in occasionally encountered but important diagnostic scenarios. Further evaluating cases with inherent pitfalls including those with seemingly nondiagnostic findings, instances of excluding concomitant microinvasive carcinoma, and recognizing tangential sections that mimic atypical epithelial proliferations will be discussed. Attention will also be drawn to examples of core biopsies containing multiple diagnoses as well as the use of multiplex immunohistochemistry in these specimens.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lee AHS, Salinas NMV, Hodi Z, et al. The value of examination of multiple levels of mammary needle core biopsy specimens taken for investigation of lesions other than calcification. J Clin Pathol. 2012;65:1097–9.
Grimes MM, Karageorge LS, Hogge JP. Does exhaustive search for microcalcifications improve diagnostic yield in stereotactic core needle breast biopsies? Mod Pathol. 2001;1494:350–3.
Rosen PP. Columnar cell hyperplasia is associated with lobular carcinoma in situ and tubular carcinoma. Am J Surg Pathol. 1999;23(12):1561.
Abdel-Fatah TM, Powe DG, Hodi Z, et al. High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. Am J Surg Pathol. 2007;31(3):417–26.
Dixon AR, Bathany C, Tsuei M, et al. Recent developments in multiplexing techniques for immunohistochemistry. Expert Rev Mol Diagn. 2015;15(9):1171–86.
Ross DS, Liu YF, Pipa J, Shin SJ. The diagnostic utility of the minimal carcinoma triple stain in breast carcinomas. Am J Clin Pathol. 2013;139:62–70.
Reisenbichler ES, Balmer NN, Adams AL, et al. Luminal cytokeratin expression profiles of breast papillomas and papillary carcinomas and the utility of a cytokeratin 5/p63/cytokeratin 8/18 antibody in their distinction. Mod Pathol. 2011;139:62–70.
Reisenbichler ES, Ross JR, Hameed O. The clinical use of a p63/cytokeratin 7/18/cytokeratin 5/14 antibody cocktail in diagnostic breast pathology. Ann Diagn Pathol. 2014;18:313–8.
Jain RK, Mehta R, Dimitrov R, et al. Atypical ductal hyperplasia: interobserver and intraobserver variability. Mod Pathol. 2011;2497:917–23.
Ginter PS, Varma S, Liu YF, Shin SJ. The minimal carcinoma triple stain is superior to commercially available multiplex immunohistochemical stains breast triple stain and LC/DC breast cocktail. Am J Clin Pathol. 2015;144:869–79.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Shin, S.J., Ginter, P.S. (2016). Multiples in Core Biopsy Samples. In: Shin, S. (eds) A Comprehensive Guide to Core Needle Biopsies of the Breast . Springer, Cham. https://doi.org/10.1007/978-3-319-26291-8_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-26291-8_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-26289-5
Online ISBN: 978-3-319-26291-8
eBook Packages: MedicineMedicine (R0)