Abstract
Cellular senescence, an outcome of finite proliferative, limited repair and defence capacity of normal cells, is a widely accepted in vitro model for ageing studies. In a sharp contrast to cancer cells, it is firmly regulated by cell cycle checkpoints that ensure evasion of stressed and genetically modified cells, limiting their expansion and serve as an innate check to carcinogenesis. Tumour suppressors and their regulatory proteins play key roles, both as molecular sensors and regulators in this process. Aim of the present chapter is to sketch a brief understanding on how cellular senescence is regulated by major tumour suppressor and cell cycle checkpoint proteins as well as by some emerging molecules.
Keywords
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Wadhwa, R., Kaul, Z., Kaul, S.C. (2016). Cell Cycle Checkpoints and Senescence. In: Rattan, S., Hayflick, L. (eds) Cellular Ageing and Replicative Senescence. Healthy Ageing and Longevity. Springer, Cham. https://doi.org/10.1007/978-3-319-26239-0_9
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