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Ageing and Senescence in Immune Cells In Vitro and In Vivo

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Book cover Cellular Ageing and Replicative Senescence

Part of the book series: Healthy Ageing and Longevity ((HAL))

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Abstract

Since the discovery of T cell growth factor, now known as interleukin 2 (IL 2), it has been possible to serially culture normal human T lymphocytes, something that cannot be done with other immune cells such as B cells or monocytes/macrophages. This chapter will focus on cloning efficiencies of T cells from younger or older subjects, their longevity in culture under different conditions and the progressive changes occurring over their in vitro lifespan.

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Authors and Affiliations

  1. Center for Medical Research, University of Tubingen, Tubingen, Germany

    Graham Pawelec

  2. School of Science and Technology, College of Arts and Science, Nottingham Trent University, Nottingham, UK

    Graham Pawelec & Yvonne Barnett

Authors
  1. Graham Pawelec
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  2. Yvonne Barnett
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Corresponding author

Correspondence to Graham Pawelec .

Editor information

Editors and Affiliations

  1. Dep of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Suresh I.S. Rattan

  2. Department of Anatomy,School of Medicine, University of California, San Francisco, USA

    Leonard Hayflick

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Pawelec, G., Barnett, Y. (2016). Ageing and Senescence in Immune Cells In Vitro and In Vivo. In: Rattan, S., Hayflick, L. (eds) Cellular Ageing and Replicative Senescence. Healthy Ageing and Longevity. Springer, Cham. https://doi.org/10.1007/978-3-319-26239-0_6

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