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Cellular Ageing and Replicative Senescence pp 243–262Cite as

Stress-Induced (Premature) Senescence

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Part of the book series: Healthy Ageing and Longevity ((HAL))

Abstract

Three main roads lead to senescence: telomere-dependent replicative senescence, oncogene-induced senescence and stress-induced (premature) senescence. This latter type of senescence appears after exposure of normal, immortalized or transformed cells to stress of chemical or physical nature inducing oxidative stress and/or DNA damage. After these exposures, chronic or acute, single or multiple, stressed cells developed a “senescence-like” phenotype. This “senescence-like” phenotype presents several biomarkers of cellular senescence such as irreversible growth arrest, morphological change, senescence-associated ß-galactosidase (SA-ßgal) activity and senescence-associated secretory phenotype (SASP). However, large-scale studies of transcriptome and proteome of cells in replicative senescence or in stress-induced senescence show that although they share similarities, the two phenotypes are not identical. Different signaling pathways involved in the development of stress-induced senescence are presented as those dependent on TGF-ß1, p38MAPK, IGF-R1 and DNA damage. The possible induction of this type of senescence in vivo and in cancer treatment is discussed.

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References

  • Aan GJ, Hairi HA, Makpol S, Rahman MA, Karsani SA (2013) Differences in protein changes between stress-induced premature senescence and replicative senescence states. Electrophoresis 34(15):2209–2217. doi:10.1002/elps.201300086

    Article  CAS  PubMed  Google Scholar 

  • Acosta JC, Gil J (2012) Senescence: a new weapon for cancer therapy. Trends Cell Biol 22(4):211–219. doi:10.1016/j.tcb.2011.11.006

    Article  CAS  PubMed  Google Scholar 

  • Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-Machin MA, von Zglinicki T, Saretzki G (2008) Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci 121(Pt 7):1046–1053. doi:10.1242/jcs.019372

    Article  CAS  PubMed  Google Scholar 

  • Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC (1996) Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A 93(24):13742–13747

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Alekseenko LL, Zemelko VI, Domnina AP, Lyublinskaya OG, Zenin VV, Pugovkina NA, Kozhukharova IV, Borodkina AV, Grinchuk TM, Fridlyanskaya II, Nikolsky NN (2014) Sublethal heat shock induces premature senescence rather than apoptosis in human mesenchymal stem cells. Cell Stress Chaperones 19(3):355–366. doi:10.1007/s12192-013-0463-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aoshiba K, Tsuji T, Nagai A (2003) Bleomycin induces cellular senescence in alveolar epithelial cells. Eur Respir J 22(3):436–443

    Article  CAS  PubMed  Google Scholar 

  • Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479(7372):232–236. doi:10.1038/nature10600

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bavik C, Coleman I, Dean JP, Knudsen B, Plymate S, Nelson PS (2006) The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res 66(2):794–802. doi:10.1158/0008-5472.CAN-05-1716

    Article  CAS  PubMed  Google Scholar 

  • Bayreuther K, Rodemann HP, Hommel R, Dittmann K, Albiez M, Francz PI (1988) Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc Natl Acad Sci U S A 85(14):5112–5116

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Berndtsson M, Hagg M, Panaretakis T, Havelka AM, Shoshan MC, Linder S (2007) Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA. Int J Cancer 120(1):175–180. doi:10.1002/ijc.22132

    Article  CAS  PubMed  Google Scholar 

  • Bilsland A, Keith W (2010) Mining cellular senescence for drug targets. In: Sedivy JM, Adams PD (eds) Cellular senescence and tumor suppression. Springer, New York, pp 235–265

    Chapter  Google Scholar 

  • Boilan E, Winant V, Dumortier E, Piret JP, Bonfitto F, Osiewacz HD, Debacq-Chainiaux F, Toussaint O (2013) Role of p38MAPK and oxidative stress in copper-induced senescence. Age (Dordr) 35(6):2255–2271. doi:10.1007/s11357-013-9521-3

    Article  CAS  Google Scholar 

  • Borlon C, Chretien A, Debacq-Chainiaux F, Toussaint O (2007) Transient increased extracellular release of H2O2 during establishment of UVB-induced premature senescence. Ann N Y Acad Sci 1119:72–77. doi:10.1196/annals.1404.002

    Article  CAS  PubMed  Google Scholar 

  • Brewer GJ (2007) Iron and copper toxicity in diseases of aging, particularly atherosclerosis and Alzheimer’s disease. Exp Biol Med (Maywood) 232(2):323–335

    CAS  Google Scholar 

  • Campisi J, d’Adda di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8(9):729–740. doi:10.1038/nrm2233

    Article  CAS  PubMed  Google Scholar 

  • Campisi J, Dimri GP, Hara E (1996) Control of replicative senescence. In: Rowe J, Rowe J, Schneider E (eds) Handbook of the biology of aging. Academic Press, San Diego, pp 121–149

    Google Scholar 

  • Chen Q, Ames BN (1994) Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci U S A 91(10):4130–4134

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen QM, Bartholomew JC, Campisi J, Acosta M, Reagan JD, Ames BN (1998) Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J 332(Pt 1):43–50

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chen QM, Prowse KR, Tu VC, Purdom S, Linskens MH (2001) Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp Cell Res 265(2):294–303. doi:10.1006/excr.2001.5182

    Article  CAS  PubMed  Google Scholar 

  • Chen J, Brodsky SV, Goligorsky DM, Hampel DJ, Li H, Gross SS, Goligorsky MS (2002) Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circ Res 90(12):1290–1298

    Article  CAS  PubMed  Google Scholar 

  • Chiu CC, Li CH, Ung MW, Fuh TS, Chen WL, Fang K (2005) Etoposide (VP-16) elicits apoptosis following prolonged G2-M cell arrest in p53-mutated human non-small cell lung cancer cells. Cancer Lett 223(2):249–258. doi:10.1016/j.canlet.2004.10.049

    Article  CAS  PubMed  Google Scholar 

  • Choi J, Shendrik I, Peacocke M, Peehl D, Buttyan R, Ikeguchi EF, Katz AE, Benson MC (2000) Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia. Urology 56(1):160–166

    Article  CAS  PubMed  Google Scholar 

  • Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP, Leeuwenburgh C (2009) Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 8(1):18–30. doi:10.1016/j.arr.2008.07.002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6(12):2853–2868. doi:10.1371/journal.pbio.0060301

    Article  CAS  PubMed  Google Scholar 

  • d’Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP, Jackson SP (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426(6963):194–198. doi:10.1038/nature02118

    Article  PubMed  CAS  Google Scholar 

  • de Magalhaes JP, Chainiaux F, Remacle J, Toussaint O (2002) Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts. FEBS Lett 523(1–3):157–162

    Article  PubMed  Google Scholar 

  • Debacq-Chainiaux F, Borlon C, Pascal T, Royer V, Eliaers F, Ninane N, Carrard G, Friguet B, de Longueville F, Boffe S, Remacle J, Toussaint O (2005) Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway. J Cell Sci 118(Pt 4):743–758. doi:10.1242/jcs.01651

    Article  CAS  PubMed  Google Scholar 

  • Debacq-Chainiaux F, Pascal T, Boilan E, Bastin C, Bauwens E, Toussaint O (2008) Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts. Free Radic Biol Med 44(10):1817–1832. doi:10.1016/j.freeradbiomed.2008.02.001

    Article  CAS  PubMed  Google Scholar 

  • Debacq-Chainiaux F, Boilan E, Dedessus Le Moutier J, Weemaels G, Toussaint O (2010) p38(MAPK) in the senescence of human and murine fibroblasts. Adv Exp Med Biol 694:126–137

    Article  CAS  PubMed  Google Scholar 

  • Dierick JF, Kalume DE, Wenders F, Salmon M, Dieu M, Raes M, Roepstorff P, Toussaint O (2002) Identification of 30 protein species involved in replicative senescence and stress-induced premature senescence. FEBS Lett 531(3):499–504

    Article  CAS  PubMed  Google Scholar 

  • Dierick JF, Frippiat C, Salmon M, Chainiaux F, Toussaint O (2003) Stress, cells and tissue aging. In: Rattan SIS (ed) Modulating aging and longevity. Kluwer Academic Publishers, Dordrecht/Boston, pp 101–125

    Google Scholar 

  • Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92(20):9363–9367

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dings J, Meixensberger J, Jager A, Roosen K (1998) Clinical experience with 118 brain tissue oxygen partial pressure catheter probes. Neurosurgery 43(5):1082–1095

    Article  CAS  PubMed  Google Scholar 

  • Duan L, Sterba K, Kolomeichuk S, Kim H, Brown PH, Chambers TC (2007) Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. Biochem Pharmacol 73(4):481–490. doi:10.1016/j.bcp.2006.10.026

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dumont P, Balbeur L, Remacle J, Toussaint O (2000a) Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition. J Anat 197(Pt 4):529–537

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dumont P, Burton M, Chen QM, Gonos ES, Frippiat C, Mazarati JB, Eliaers F, Remacle J, Toussaint O (2000b) Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Radic Biol Med 28(3):361–373

    Article  CAS  PubMed  Google Scholar 

  • Dumont P, Royer V, Pascal T, Dierick JF, Chainiaux F, Frippiat C, de Magalhaes JP, Eliaers F, Remacle J, Toussaint O (2001) Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence. FEBS Lett 502(3):109–112

    Article  CAS  PubMed  Google Scholar 

  • Fenton M, Barker S, Kurz DJ, Erusalimsky JD (2001) Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries. Arterioscler Thromb Vasc Biol 21(2):220–226

    Article  CAS  PubMed  Google Scholar 

  • Freund A, Patil CK, Campisi J (2011) p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 30(8):1536–1548. doi:10.1038/emboj.2011.69

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Freund A, Laberge RM, Demaria M, Campisi J (2012) Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell 23(11):2066–2075. doi:10.1091/mbc.E11-10-0884

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Frippiat C, Chen QM, Zdanov S, Magalhaes JP, Remacle J, Toussaint O (2001) Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem 276(4):2531–2537. doi:10.1074/jbc.M006809200

    Article  CAS  PubMed  Google Scholar 

  • Frippiat C, Dewelle J, Remacle J, Toussaint O (2002) Signal transduction in H2O2-induced senescence-like phenotype in human diploid fibroblasts. Free Radic Biol Med 33(10):1334–1346

    Article  CAS  PubMed  Google Scholar 

  • Going JJ, Stuart RC, Downie M, Fletcher-Monaghan AJ, Keith WN (2002) ‘Senescence-associated’ beta-galactosidase activity in the upper gastrointestinal tract. J Pathol 196(4):394–400. doi:10.1002/path.1059

    Article  CAS  PubMed  Google Scholar 

  • Gorbunova V, Seluanov A, Pereira-Smith OM (2002) Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J Biol Chem 277(41):38540–38549. doi:10.1074/jbc.M202671200

    Article  CAS  PubMed  Google Scholar 

  • Gorgoulis VG, Halazonetis TD (2010) Oncogene-induced senescence: the bright and dark side of the response. Curr Opin Cell Biol 22(6):816–827. doi:10.1016/j.ceb.2010.07.013

    Article  CAS  PubMed  Google Scholar 

  • Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345(6274):458–460. doi:10.1038/345458a0

    Article  CAS  PubMed  Google Scholar 

  • Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25:585–621

    Article  CAS  PubMed  Google Scholar 

  • Hegde ML, Hegde PM, Rao KS, Mitra S (2011) Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword. J Alzheimers Dis 24(Suppl 2):183–198. doi:10.3233/JAD-2011-110281

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hornsby PJ (2010) Stress-induced senescence. In: Sedivy JM, Adams PD (eds) Cellular senescence and tumor suppression. Springer, New York, pp 85–106

    Chapter  Google Scholar 

  • Igarashi K, Sakimoto I, Kataoka K, Ohta K, Miura M (2007) Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells. Exp Cell Res 313(15):3326–3336. doi:10.1016/j.yexcr.2007.06.001

    Article  CAS  PubMed  Google Scholar 

  • Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T (2014) Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun 2:4172. doi:10.1038/ncomms5172

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Killilea DW, Wong SL, Cahaya HS, Atamna H, Ames BN (2004) Iron accumulation during cellular senescence. Ann N Y Acad Sci 1019:365–367. doi:10.1196/annals.1297.063

    Article  CAS  PubMed  Google Scholar 

  • Kim KS, Kim JE, Choi KJ, Bae S, Kim DH (2014) Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells. Int J Radiat Biol 90(1):71–80. doi:10.3109/09553002.2014.859763

    Article  CAS  PubMed  Google Scholar 

  • Kurz DJ, Decary S, Hong Y, Erusalimsky JD (2000) Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci 113(Pt 20):3613–3622

    CAS  PubMed  Google Scholar 

  • Kurz DJ, Decary S, Hong Y, Trivier E, Akhmedov A, Erusalimsky JD (2004) Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 117(Pt 11):2417–2426. doi:10.1242/jcs.01097

    Article  CAS  PubMed  Google Scholar 

  • Lewis DA, Yi Q, Travers JB, Spandau DF (2008) UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53. Mol Biol Cell 19(4):1346–1353. doi:10.1091/mbc.E07-10-1041

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153(6):1194–1217. doi:10.1016/j.cell.2013.05.039

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ma W, Wlaschek M, Hommel C, Schneider LA, Scharffetter-Kochanek K (2002) Psoralen plus UVA (PUVA) induced premature senescence as a model for stress-induced premature senescence. Exp Gerontol 37(10–11):1197–1201

    Article  CAS  PubMed  Google Scholar 

  • Maejima Y, Adachi S, Ito H, Hirao K, Isobe M (2008) Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage. Aging Cell 7(2):125–136. doi:10.1111/j.1474-9726.2007.00358.x

    Article  CAS  PubMed  Google Scholar 

  • Matos L, Gouveia A, Almeida H (2012) Copper ability to induce premature senescence in human fibroblasts. Age (Dordr) 34(4):783–794. doi:10.1007/s11357-011-9276-7

    Article  CAS  Google Scholar 

  • Medrano EE, Im S, Yang F, Abdel-Malek ZA (1995) Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein. Cancer Res 55(18):4047–4052

    CAS  PubMed  Google Scholar 

  • Mendez MV, Stanley A, Phillips T, Murphy M, Menzoian JO, Park HY (1998) Fibroblasts cultured from distal lower extremities in patients with venous reflux display cellular characteristics of senescence. J Vasc Surg 28(6):1040–1050

    Article  CAS  PubMed  Google Scholar 

  • Muller KC, Welker L, Paasch K, Feindt B, Erpenbeck VJ, Hohlfeld JM, Krug N, Nakashima M, Branscheid D, Magnussen H, Jorres RA, Holz O (2006) Lung fibroblasts from patients with emphysema show markers of senescence in vitro. Respir Res 7:32. doi:10.1186/1465-9921-7-32

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nardella C, Clohessy JG, Alimonti A, Pandolfi PP (2011) Pro-senescence therapy for cancer treatment. Nat Rev Cancer 11(7):503–511. doi:10.1038/nrc3057

    Article  CAS  PubMed  Google Scholar 

  • Packer L, Fuehr K (1977) Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature 267(5610):423–425

    Article  CAS  PubMed  Google Scholar 

  • Palm W, de Lange T (2008) How shelterin protects mammalian telomeres. Annu Rev Genet 42:301–334. doi:10.1146/annurev.genet.41.110306.130350

    Article  CAS  PubMed  Google Scholar 

  • Panganiban RA, Day RM (2013) Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence. PLoS One 8(10):e78589. doi:10.1371/journal.pone.0078589

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Panganiban RA, Mungunsukh O, Day RM (2013) X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells. Int J Radiat Biol 89(8):656–667. doi:10.3109/09553002.2012.711502

    Article  CAS  PubMed  Google Scholar 

  • Paradis V, Youssef N, Dargere D, Ba N, Bonvoust F, Deschatrette J, Bedossa P (2001) Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum Pathol 32(3):327–332. doi:10.1053/hupa.2001.22747

    Article  CAS  PubMed  Google Scholar 

  • Pascal T, Debacq-Chainiaux F, Chretien A, Bastin C, Dabee AF, Bertholet V, Remacle J, Toussaint O (2005) Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett 579(17):3651–3659. doi:10.1016/j.febslet.2005.05.056

    Article  CAS  PubMed  Google Scholar 

  • Piegari E, De Angelis A, Cappetta D, Russo R, Esposito G, Costantino S, Graiani G, Frati C, Prezioso L, Berrino L, Urbanek K, Quaini F, Rossi F (2013) Doxorubicin induces senescence and impairs function of human cardiac progenitor cells. Basic Res Cardiol 108(2):334. doi:10.1007/s00395-013-0334-4

    Article  PubMed  CAS  Google Scholar 

  • Ressler S, Bartkova J, Niederegger H, Bartek J, Scharffetter-Kochanek K, Jansen-Durr P, Wlaschek M (2006) p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell 5(5):379–389. doi:10.1111/j.1474-9726.2006.00231.x

    Article  CAS  PubMed  Google Scholar 

  • Riedemann J, Macaulay VM (2006) IGF1R signalling and its inhibition. Endocr Relat Cancer 13(Suppl 1):S33–S43. doi:10.1677/erc.1.01280

    Article  CAS  PubMed  Google Scholar 

  • Roberson RS, Kussick SJ, Vallieres E, Chen SY, Wu DY (2005) Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res 65(7):2795–2803. doi:10.1158/0008-5472.CAN-04-1270

    Article  CAS  PubMed  Google Scholar 

  • Robles SJ, Adami GR (1998) Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16(9):1113–1123. doi:10.1038/sj.onc.1201862

    Article  CAS  PubMed  Google Scholar 

  • Rodemann HP (1989) Differential degradation of intracellular proteins in human skin fibroblasts of mitotic and mitomycin-C (MMC)-induced postmitotic differentiation states in vitro. Differentiation 42(1):37–43

    Article  CAS  PubMed  Google Scholar 

  • Rodemann HP, Bayreuther K, Francz PI, Dittmann K, Albiez M (1989a) Selective enrichment and biochemical characterization of seven human skin fibroblasts cell types in vitro. Exp Cell Res 180(1):84–93

    Article  CAS  PubMed  Google Scholar 

  • Rodemann HP, Bayreuther K, Pfleiderer G (1989b) The differentiation of normal and transformed human fibroblasts in vitro is influenced by electromagnetic fields. Exp Cell Res 182(2):610–621

    Article  CAS  PubMed  Google Scholar 

  • Rudolf E, Rezacova K, Cervinka M (2014) Activation of p38 and changes in mitochondria accompany autophagy to premature senescence-like phenotype switch upon chronic exposure to selenite in colon fibroblasts. Toxicol Lett 231(1):29–37. doi:10.1016/j.toxlet.2014.09.006

    Article  CAS  PubMed  Google Scholar 

  • Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, Ibrahim JG, Jolly TA, Williams G, Carey LA, Drobish A, Gordon BB, Alston S, Hurria A, Kleinhans K, Rudolph KL, Sharpless NE, Muss HB (2014) Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. J Natl Cancer Inst 106(4):dju057

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88(5):593–602

    Article  CAS  PubMed  Google Scholar 

  • Sherr CJ, Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13(12):1501–1512

    Article  CAS  PubMed  Google Scholar 

  • Sliwinska MA, Mosieniak G, Wolanin K, Babik A, Piwocka K, Magalska A, Szczepanowska J, Fronk J, Sikora E (2009) Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells. Mech Ageing Dev 130(1–2):24–32. doi:10.1016/j.mad.2008.04.011

    Article  CAS  PubMed  Google Scholar 

  • Stucker M, Struk A, Altmeyer P, Herde M, Baumgartl H, Lubbers DW (2002) The cutaneous uptake of atmospheric oxygen contributes significantly to the oxygen supply of human dermis and epidermis. J Physiol 538(Pt 3):985–994

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Suzuki M, Boothman DA (2008) Stress-induced premature senescence (SIPS) – influence of SIPS on radiotherapy. J Radiat Res 49(2):105–112

    Article  PubMed  Google Scholar 

  • Suzuki K, Mori I, Nakayama Y, Miyakoda M, Kodama S, Watanabe M (2001) Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening. Radiat Res 155(1 Pt 2):248–253

    Article  CAS  PubMed  Google Scholar 

  • Takai H, Smogorzewska A, de Lange T (2003) DNA damage foci at dysfunctional telomeres. Curr Biol 13(17):1549–1556

    Article  CAS  PubMed  Google Scholar 

  • te Poele RH, Okorokov AL, Jardine L, Cummings J, Joel SP (2002) DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 62(6):1876–1883

    Google Scholar 

  • Toussaint O, Raes M, Remacle J (1991) Aging as a multi-step process characterized by a lowering of entropy production leading the cell to a sequence of defined stages. Mech Ageing Dev 61(1):45–64

    Article  CAS  PubMed  Google Scholar 

  • Toussaint O, Medrano EE, von Zglinicki T (2000) Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 35(8):927–945

    Article  CAS  PubMed  Google Scholar 

  • Toussaint O, Remacle J, Dierick JF, Pascal T, Frippiat C, Zdanov S, Magalhaes JP, Royer V, Chainiaux F (2002) From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing. Int J Biochem Cell Biol 34(11):1415–1429

    Article  CAS  PubMed  Google Scholar 

  • Toussaint O, Weemaels G, Debacq-Chainiaux F, Scharffetter-Kochanek K, Wlaschek M (2011) Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology. J Cell Physiol 226(2):315–321. doi:10.1002/jcp.22416

    Article  CAS  PubMed  Google Scholar 

  • Vedsted P, Blangsted AK, Sogaard K, Orizio C, Sjogaard G (2006) Muscle tissue oxygenation, pressure, electrical, and mechanical responses during dynamic and static voluntary contractions. Eur J Appl Physiol 96(2):165–177. doi:10.1007/s00421-004-1216-0

    Article  PubMed  Google Scholar 

  • Villalobos LA, Uryga A, Romacho T, Leivas A, Sanchez-Ferrer CF, Erusalimsky JD, Peiro C (2014) Visfatin/Nampt induces telomere damage and senescence in human endothelial cells. Int J Cardiol 175(3):573–575. doi:10.1016/j.ijcard.2014.05.028

    Article  PubMed  Google Scholar 

  • von Zglinicki T, Saretzki G, Docke W, Lotze C (1995) Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 220(1):186–193. doi:10.1006/excr.1995.1305

    Article  Google Scholar 

  • von Zglinicki T, Pilger R, Sitte N (2000) Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radic Biol Med 28(1):64–74

    Article  Google Scholar 

  • Wang W, Chen JX, Liao R, Deng Q, Zhou JJ, Huang S, Sun P (2002) Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 22(10):3389–3403

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wei S, Sedivy JM (1999) Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts. Cancer Res 59(7):1539–1543

    CAS  PubMed  Google Scholar 

  • Xu D, Neville R, Finkel T (2000) Homocysteine accelerates endothelial cell senescence. FEBS Lett 470(1):20–24

    Article  CAS  PubMed  Google Scholar 

  • Yoon G, Kim HJ, Yoon YS, Cho H, Lim IK, Lee JH (2002) Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression. Biochem J 366(Pt 2):613–621. doi:10.1042/BJ20011445

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zdanov S, Debacq-Chainiaux F, Remacle J, Toussaint O (2006a) Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts. FEBS Lett 580(27):6455–6463. doi:10.1016/j.febslet.2006.10.064

    Article  CAS  PubMed  Google Scholar 

  • Zdanov S, Remacle J, Toussaint O (2006b) Establishment of H2O2-induced premature senescence in human fibroblasts concomitant with increased cellular production of H2O2. Ann N Y Acad Sci 1067:210–216. doi:10.1196/annals.1354.025

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

O. Toussaint, F. Debacq-Chainiaux and Marie Toutfaire are respectively Senior Research Associate, Research Associate and recipient of a Televie grant of the FNRS, Belgium. We thank the European Commission and the DG06 of the Walloon Region of Belgium for Large-scale integrating Collaborative projects “Nanovalid” (#NMP-FP7-2010-1.3-1) and “Nanoreg” (#310584), for “Qnano” (#INFRASTRUCTURE-2010-1-262163) and “Caregiver” (#1318184) projects.

The authors declare no conflict of interest.

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Authors and Affiliations

  1. NARILIS-URBC, University of Namur, Namur, Belgium

    Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaire & Olivier Toussaint

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  1. Florence Debacq-Chainiaux
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  2. Randa Ben Ameur
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  3. Emilie Bauwens
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  4. Elise Dumortier
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  5. Marie Toutfaire
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  6. Olivier Toussaint
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Correspondence to Florence Debacq-Chainiaux .

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Editors and Affiliations

  1. Dep of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Suresh I.S. Rattan

  2. Department of Anatomy,School of Medicine, University of California, San Francisco, USA

    Leonard Hayflick

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Debacq-Chainiaux, F., Ben Ameur, R., Bauwens, E., Dumortier, E., Toutfaire, M., Toussaint, O. (2016). Stress-Induced (Premature) Senescence. In: Rattan, S., Hayflick, L. (eds) Cellular Ageing and Replicative Senescence. Healthy Ageing and Longevity. Springer, Cham. https://doi.org/10.1007/978-3-319-26239-0_13

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