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Eurycoma longifolia

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Abstract

Tongkat Ali sampling

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Selected References

  • Abd Jalil MA, Shuid AN, Muhammad N (2012) Role of medicinal plants and natural products on osteoporotic fracture healing. Evid Based Complement Alternat Med 2012:714512

    Article  PubMed Central  PubMed  Google Scholar 

  • Abdulghani M, Hussin AH, Sulaiman SA, Chan KL (2012) The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol 12(2):247–255

    Article  PubMed  Google Scholar 

  • Abdullah MZ, Rahman ASA, Shakaff AYM, Noor AM (2004) Discrimination and classification of Eurycoma longifolia Jack in medicinal foods by means of a DSP-based electronic taste sensor. Trans Inst Measur Control 26(1):19–39

    Article  Google Scholar 

  • Al-Salahi OSA, Chan KL, Abdul Majid AMS, Al-Suede FSR, Mohammed Saghir SA, Abdullah WZ, Ahamed MBK, Yusoff NM (2013) Anti-angiogenic quassinoid-rich fraction from Eurycoma longifolia modulates endothelial cell function. Microvasc Res 90:30–39

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Cheang HS (1999) Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol 79(4):497–500

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Cheang HS (2001) Effects of Eurycoma longifolia Jack on laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats. Arch Pharm Res 24(5):437–440

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Lee KL (2002a) Effect of Eurycoma longifolia Jack on libido in middle-aged male rats. J Basic Clin Physiol Pharmacol 13(3):249–254

    Article  PubMed  Google Scholar 

  • Ang HH, Lee K (2002b) Effects of Eurycoma longifolia Jack on masculine copulatory behaviour in middle aged male rats – a comparison study. Nat Prod Sci 8(2):44–47

    CAS  Google Scholar 

  • Ang HH, Lee KL (2002c) Effect of Eurycoma longifolia Jack on orientation activities in middle-aged male rats. Fundam Clin Pharmacol 16(6):479–83

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Lee KL (2006) Contamination of mercury in Tongkat Ali hitam herbal preparations. Food Chem Toxicol 44(8):1245–1250

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Ngai TH (2001) Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack. Fundam Clin Pharmacol 15(4):265–268

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Sim MK (1997a) Effects of Eurycoma longifolia Jack on penile erection index and homosexual mounting in rats. Pharm Pharmacol Comm 3:117–119

    CAS  Google Scholar 

  • Ang HH, Sim MK (1997b) Effects of Eurycoma longifolia Jack on sexual behaviour of male rats. Arch Pharm Res 20(6):656–659

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Sim MK (1997c) Eurycoma longifolia Jack enhances libido in sexually experienced male rats. Exp Anim 46(4):287–290

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Sim MK (1998a) Aphrodisiac evaluation in sexually naive male mice after chronic administration of Eurycoma longifolia Jack. Nat Prod Sci 4(2):58–61

    CAS  Google Scholar 

  • Ang HH, Sim MK (1998b) Eurycoma longifolia increases sexual motivation in sexually naive male rats. Arch Pharm Res 21(6):779–781

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Sim MK (1998c) Eurycoma longifolia Jack and orientation activities in sexually experienced male rats. Biol Pharm Bull 21(2):153–155

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Sim MK (1999) Eurycoma longifolia Jack and orientation activities in sexually experienced male rats. Biol Pharm Bull 21(2):153–155

    Article  Google Scholar 

  • Ang HH, Chan KL, Mak JW (1995a) Effect of 7-day daily replacement of culture medium containing Eurycoma longifolia Jack constituents on the Malaysian Plasmodium falciparum isolates. J Ethnopharmacol 49(3):171–175

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Chan KL, Mak JW (1995b) In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates. Planta Med 61(2):177–178

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Cheang HS, Yusof AP (2000a) Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats. Exp Anim 49(1):35–38

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Hitotsuyanagi Y, Takeya K (2000b) Eurylactones A-C, novel quassinoids from Eurycoma longifolia. Tetrahedron Lett 41(35):6849–6853

    Article  CAS  Google Scholar 

  • Ang HH, Ikeda S, Gan EK (2001) Evaluation of the potency activity of aphrodisiac in Eurycoma longifolia Jack. Phytother Res 15(5):435–436

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Hitotsuyanagi Y, Fukaya H, Takeya K (2002) Quassinoids from Eurycoma longifolia. Phytochemistry 59(8):833–837

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Lee KL, Kiyoshi M (2003a) Eurycoma longifolia Jack enhances sexual motivation in middle-aged male mice. J Basic Clin Physiol Pharmacol 14(3):301–308

    Article  PubMed  Google Scholar 

  • Ang HH, Ngai TH, Tan TH (2003b) Effects of Eurycoma longifolia Jack on sexual qualities in middle aged male rats. Phytomedicine 10(6–7):590–593

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Lee EL, Cheang HS (2004a) Determination of mercury by cold vapor atomic absorption spectrophotometer in Tongkat Ali preparations obtained in Malaysia. Int J Toxicol 23(1):65–71

    Article  CAS  PubMed  Google Scholar 

  • Ang HH, Lee KL, Kiyoshi M (2004b) Sexual arousal in sexually sluggish old male rats after oral administration of Eurycoma longifolia Jack. J Basic Clin Physiol Pharmacol 15(3–4):303–309

    PubMed  Google Scholar 

  • Asiah O, Nurhanan MY, Ilham MA (2007) Determination of bioactive peptide (4.3 kDa) as an aphrodisiac marker in six Malaysia plants. J Trop For Sci 19(1):61–63

    Google Scholar 

  • Athimulam A, Kumaresan S, Foo DCY, Sarmidi MR, Aziz RA (2006) Modeling and optimization of E. longifolia water extract production. Food Bioprod Process 84(C2):139–149

    Article  Google Scholar 

  • Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA (2003) Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull 51(11):1301–1303

    Article  CAS  PubMed  Google Scholar 

  • Bhat R, Karim AA (2010) Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia 1(7):669–679

    Article  Google Scholar 

  • Chan KL, Choo CY (2002) The toxicity of some quassinoids from Eurycoma longifolia. Planta Med 68(7):662–664

    Article  CAS  PubMed  Google Scholar 

  • Chan KL, O’Neill MJ, Phillipson JD, Warhurst DC (1986) Plants as sources of antimalarial drugs. Part 3. Eurycoma longifolia. Planta Med 2:105–107

    Article  PubMed  Google Scholar 

  • Chan KL, Lee S, Sam TW, Han BH (1989) A quassinoid glycoside from the roots of Eurycoma longifolia. Phytochemistry 28(10):2857–2859

    Article  CAS  Google Scholar 

  • Chan KL, Lee SP, Sam TW, Tan SC, Noguchi H, Sankawa U (1991) 13β, 18-dihydroeurycomanol, a quassinoid from Eurycoma longifolia. Phytochemistry 30(9):3138–3141

    Article  CAS  Google Scholar 

  • Chan KL, Iitaka Y, Noguchi H, Sugiyama H, Saito I, Sankawa U (1992) 6α-Hydroxyeurycomalactone, a quassinoid from Eurycoma longifolia. Phytochemistry 31(12):4295–4298

    Article  CAS  Google Scholar 

  • Chan KL, Lee SP, Yuen KH (1995) Antipyretic activity of quassinoids from Eurycoma longifolia Jack. Paper presented at the 11th chemical seminar on natural products, 25–28 June, 1995. UNIMAS, Sarawak, Malaysia, Proceedings pp 197–204

    Google Scholar 

  • Chan KL, Choo CY, Morita H, Itokawa H (1998) High performance liquid chromatography in phytochemical analysis of Eurycoma longifolia. Planta Med 64(8):741–745

    Article  CAS  PubMed  Google Scholar 

  • Chan KL, Choo CY, Abdullah NR, Ismail Z (2004) Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol 92(2–3):223–227

    Article  CAS  PubMed  Google Scholar 

  • Chan KL, Choo CY, Abdullah NR (2005) Semisynthetic 15-O-acyl- and 1,15-di-O-acyleurycomanones from Eurycoma longifolia as potential antimalarials. Planta Med 71(10):967–969

    Google Scholar 

  • Chan KL, Low BS, Teh CH, Das PK (2009) The effect of Eurycoma longifolia on sperm quality of male rats. Nat Prod Commun 4(10):1331–6

    CAS  PubMed  Google Scholar 

  • Chan KL, Low BS, Ho DSS (2010) Polar organic extract of Eurycoma longifolia. US Patent 20100221370 A1

    Google Scholar 

  • Chiou WF, Wu TS (2012) 9-hydroxycanthin-6-one induces penile erection and delays ejaculation. J Sex Med 9(4):1027–1036

    Article  CAS  PubMed  Google Scholar 

  • Choo CY, Chan KL (2002) High performance liquid chromatography analysis of canthinone alkaloids from Eurycoma longifolia. Planta Med 68(4):382–384

    Article  CAS  PubMed  Google Scholar 

  • Choudhary YK, Bommu P, Yee KM, Zulkawi N (2012) Acute, sub acute and subchronic 90-days toxicity of Eurycoma longifolia aqueous extract (Physta®) in Wistar rats. Int J Pharm Pharm Sci 4:232–238

    Google Scholar 

  • Chua LS, Amin NAM, Neo JCH, Lee TH, Lee CT, Sarmidi MR, Aziz RA (2011) LC–MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang). J Chromatogr B 879(32):3909–3919

    Article  CAS  Google Scholar 

  • Chua LS, Abdul-Rahman N, Rosidi B, Lee CT (2013) Plant proteins, minerals and trace elements of Eurycoma longifolia (Tongkat Ali). Nat Prod Res 27(4–5):314–318

    Article  CAS  PubMed  Google Scholar 

  • Darise M, Kohda H, Mizutani K, Tanaka O (1982) Eurycomanone and eurycomanol, quassinoids from the roots of Eurycoma longifolia. Phytochemistry 21(8):2091–2093

    Google Scholar 

  • Erasmus N, Solomon MC, Fortuin KA, Henkel RR (2012) Effect of Eurycoma longifolia Jack (Tongkat ali) extract on human spermatozoa in vitro. Andrologia 44(5):308–314

    Article  CAS  PubMed  Google Scholar 

  • Farouk AE, Benafri A (2007) Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J 28(9):1422–1424

    PubMed  Google Scholar 

  • George A, Henkel RR (2014) Phytoandrogenic properties of Eurycoma longifolia as natural alternative to testosterone replacement therapy. Andrologia 46:708–721

    Article  CAS  PubMed  Google Scholar 

  • George A, Liske E, Chen CK, Ismail SB (2013) The Eurycoma longifolia. freeze-dried water extract-Physta® does not change normal ratios of testosterone to epitestostereone in healthy males. J Sports Med Doping Stud 3:127

    Google Scholar 

  • Hadiah JT (1996) Eurycoma longifolia Jack (Pasak Bumi). Eksplorasi 2:6

    Google Scholar 

  • Han LF, Liang GJ, Meng DL, Li N, Li X (2011) Isolation and identification of chemical constituents from Eurycoma longifolia Jack. J Shenyang Pharm Univ 28(7):517–519

    CAS  Google Scholar 

  • Henkel RR, Wang RX, Bassett SH, Chen T, Liu N, Zhu Y, Tambi MI (2013) Tongkat Ali as a potential herbal supplement for physically active male and female seniors-a pilot study. Phytother Res 28(4):544–550

    Article  PubMed  Google Scholar 

  • Hout S, Chea A, Bun SS, Elias R, Gasquet M, Timon-David P, Balansard G, Azas N (2006) Screening of selected indigenous plants of Cambodia for antiplasmodial activity. J Ethnopharmacol 107(1):12–18

    Article  PubMed  Google Scholar 

  • Hui YW, Dykes GA (2012) Modulation of cell surface hydrophobicity and attachment of bacteria to abiotic surfaces and shrimp by Malaysian herb extracts. J Food Prot 75(8):1507–1511

    Article  PubMed  Google Scholar 

  • Husen R, Pihie AH, Nallappan M (2004) Screening for antihyperglycaemic activity in several local herbs of Malaysia. J Ethnopharmacol 95(2–3):205–208

    Article  PubMed  Google Scholar 

  • Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E (2012) Randomized clinical trial on the use of PHYSTA freeze-dried water extract of Eurycoma longifolia for the Improvement of quality of life and sexual well-being in men. Evid Based Complement Alternat Med 2012:429268

    PubMed Central  PubMed  Google Scholar 

  • Itokawa H, Kishi E, Morita H, Takeya K, Iitaka Y (1991a) A new squalene-type triterpene from the woods of Eurycoma longifolia. Chem Lett 12:2221–2222

    Article  Google Scholar 

  • Itokawa H, Kishi E, Morita H, Takeya K, Iitaka Y (1991b) Eurylene, a new squalene-type triterpene from Eurycoma longifolia. Tetrahedron Lett 32(15):1803–1804

    Article  CAS  Google Scholar 

  • Itokawa H, Kishi E, Morita H (1992) Cytotoxic quassinoids and tirucallane-type triterpenes from the woods of Eurycoma longifolia. Chem Pharm Bull 40(4):1053–1055

    Article  CAS  Google Scholar 

  • Itokawa H, Qin XR, Morita H, Takeya K (1993a) C18 and C19 quassinoids from Eurycoma longifolia. J Nat Prod 56(10):1766–1771

    Article  CAS  Google Scholar 

  • Itokawa H, Qin XR, Morita H, Takeya K, Iitaka Y (1993b) Novel quassinoids from Eurycoma longifolia. Chem Pharm Bull 41(2):403–405

    Article  CAS  Google Scholar 

  • Jaganath IB, Ng LT (2000) Herbs. The Green Phamarcy of Malayais. The Commercial Press, Malaysia

    Google Scholar 

  • Jiwajinda S, Santisopasri V, Murakami A, Hirai N, Ohigashi H (2001) Quassinoids from Eurycoma longifolia as plant growth inhibitors. Phytochemistry 58(6):959–962

    Article  CAS  PubMed  Google Scholar 

  • Jiwajinda S, Santisopasri V, Murakami A, Sugiyama H, Gasquet M, Riad E, Balansard G, Ohigashi H (2002) In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. J Ethnopharmacol 82(1):55–58

    Article  CAS  PubMed  Google Scholar 

  • Kanchanapoom T, Chumsri P, Sonchai S, Kasai R, Yamasaki K (2002) Canthin-6-one alkaloids from callus cultures of Eurycoma longifolia. Nat Med (Jpn) 56(2):55–58

    CAS  Google Scholar 

  • Kardono LBS, Angerhofer CK, Tsauri S, Padmawinata K, Pezzuto JM, Kinghorn AD (1991) Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia. J Nat Prod 54(5):1360–1367

    Article  CAS  PubMed  Google Scholar 

  • Kavitha N, Noordin R, Chan KL, Sasidharan S (2012a) In vitro anti-Toxoplasma gondii activity of root extract/fractions of Eurycoma longifolia Jack. BMC Complement Altern Med 12:91

    Article  PubMed Central  PubMed  Google Scholar 

  • Kavitha N, Noordin R, Han KL, Sasidharan S (2012b) Real time anti-Toxoplasma gondii activity of an active fraction of Eurycoma longifolia root studied by in situ scanning and transmission electron microscopy. Molecules 17(8):9207–9219

    Article  PubMed  CAS  Google Scholar 

  • Kuo PC, Damu AG, Wu TS (2003a) Characterization of the water soluble fraction from the root extract of Eurycoma longifolia. Zhonghuá Yáoxué Zázhì 55(4):257–265

    CAS  Google Scholar 

  • Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS (2003b) Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod 66(10):1324–1327

    Article  CAS  PubMed  Google Scholar 

  • Kuo PC, Damu AG, Lee KH, Wu TS (2004) Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorg Med Chem 12(3):537–544

    Article  CAS  PubMed  Google Scholar 

  • Le VT, Nguyen NS (1970) Constituents of Eurycoma longifolia Jack. J Org Chem 35(4):1104–1109

    Article  Google Scholar 

  • Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW (2013) Evaluation of acute 13-week subchronic toxicity and genotoxicity of the powdered root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med 2013:102987

    PubMed Central  PubMed  Google Scholar 

  • Lin LC, Peng CY, Wang HS, Lee KW, Wang PS (2001) Reinvestigation of the chemical constituents of Eurycoma longifolia. Chinese Pharm J 53(2):97–106

    CAS  Google Scholar 

  • Low BS, Ng BH, Choy WP, Yuen KH, Chan KL (2005) Bioavailability and pharmacokinetic studies of eurycomanone from Eurycoma longifolia. Planta Med 71(9):803–807

    Article  CAS  PubMed  Google Scholar 

  • Low BS, Teh CH, Yuen KH, Chan KL (2011) Physico-chemical effects of the major quassinoids in a standardized Eurycoma longifolia extract (Fr 2) on the bioavailability and pharmacokinetic properties, and their implications for oral antimalarial activity. Nat Prod Commun 6(3):337–341

    Google Scholar 

  • Low BS, Choi SB, Abdul Wahab H, Kumar Das P, Chan KL (2013a) Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. J Ethnopharmacol 149(1):201–207

    Article  CAS  PubMed  Google Scholar 

  • Low BS, Das PK, Kl C (2013b) Standardized quassinoid-rich Eurycoma longifolia extract improved spermatogenesis and fertility in male rats via the hypothalamic-pituitary-gonadal axis. J Ethnopharmacol 145(3):706–714

    Article  CAS  PubMed  Google Scholar 

  • Low BS, Das PK, Chan KL (2014) Acute, reproductive toxicity and two-generation teratology studies of a standardized quassinoid-rich extract of Eurycoma longifolia Jack in Sprague-Dawley rats. Phytother Res 28:1022–1029

    Article  CAS  PubMed  Google Scholar 

  • Mahfudh N, Pihie AHL (2008) Eurycomanone induces apoptosis through the up-regulation of p53 in human cervical carcinoma cells. J Cancer Mol 4(4):109–115

    CAS  Google Scholar 

  • Mat Noor M, Mohd Nor AHS, Che Hassan L (2004) The effect of Eurycoma longifolia Jack (Tongkat Ali) on sexual behaviour and sperm quality in rats. Malays J Pharm Sci 2(1):53–60

    Google Scholar 

  • Maziah M, Rosli N (2009) The production of 9-methoxycanthin-6-one from callus cultures of (Eurycoma longifolia Jack) Tongkat Ali. Methods Mol Biol 547:359–369

    Article  CAS  PubMed  Google Scholar 

  • Meng DL, Li X, Han LF, Zhang LL, An WW, Li X (2014) Four new quassinoids from the roots of Eurycoma longifolia Jack. Fitoterapia 92:105–10

    Article  CAS  PubMed  Google Scholar 

  • Mitsunaga K, Koike K, Tanaka T, Ohkawa Y, Kobayashi Y, Sawaguchi T, Ohmoto T (1994) Canthin-6-one alkaloids from Eurycoma longifolia. Phytochemistry 35(3):799–802

    Article  CAS  Google Scholar 

  • Miyake K, Tezuka Y, Awale S, Li F, Kadota S (2009) Quassinoids from Eurycoma longifolia. J Nat Prod 72(12):2135–2140

    Article  CAS  PubMed  Google Scholar 

  • Miyake K, Li F, Tezuka Y, Awale S, Kadota S (2010a) Cytotoxic activity of quassinoids from Eurycoma longifolia. Nat Prod Commun 5(7):1009–1012

    CAS  PubMed  Google Scholar 

  • Miyake K, Tezuka Y, Awale S, Li F, Kadota S (2010b) Canthin-6-one alkaloids and a tirucallanoid from Eurycoma longifolia and their cytotoxic activity against a human HT-1080 fibrosarcoma cell line. Nat Prod Commun 5(1):17–22

    CAS  PubMed  Google Scholar 

  • Mohd Effendy N, Mohamed N, Muhammad N, Naina Mohamad I, Shuid AN (2012) Eurycoma longifolia: medicinal plant in the prevention and treatment of male osteoporosis due to androgen deficiency. Evid Based Complement Alternat Med 2012:125761

    PubMed Central  PubMed  Google Scholar 

  • Mohd Ridzuan MA, Noor Rain A, Zhari I, Zakiah I (2005) Effect of Eurycoma longifolia extract on the glutathione level in Plasmodium falciparum infected erythrocytes in vitro. Trop Biomed 22(2):155–163

    CAS  PubMed  Google Scholar 

  • Mohd Ridzuan MA, Sow A, Noor Rain A, Mohd Ilham A, Zakiah I (2007) Eurycoma longifolia extract-artemisinin combination: parasitemia suppression of Plasmodium yoelii-infected mice. Trop Biomed 24(1):111–118

    CAS  PubMed  Google Scholar 

  • Mohd-Fuat AR, Kofi EA, Allan GG (2007) Mutagenic and cytotoxic properties of three herbal plants from Southeast Asia. Trop Biomed 24(2):49–59

    CAS  PubMed  Google Scholar 

  • Morita H, Kishi E, Takeya K, Itokawa H, Tanaka O (1990) New quassinoids from the roots of Eurycoma longifolia. Chem Lett 19(5):749–752

    Article  Google Scholar 

  • Morita H, Kishi E, Takeya K, Itokawa H (1992) Biphenylneolignans from wood of Eurycoma longifolia. Phytochemistry 31(11):3993–3995

    Article  CAS  Google Scholar 

  • Morita H, Kishi E, Takeya K, Itokawa H, Iitaka Y (1993a) Highly oxygenated quassinoids from Eurycoma longifolia. Phytochemistry 33(3):691–696

    Article  CAS  Google Scholar 

  • Morita H, Kishi E, Takeya K, Itokawa H, Iitaka Y (1993b) Squalene derivatives from Eurycoma longifolia. Phytochemistry 34(3):765–771

    Article  CAS  Google Scholar 

  • Muhamad AS, Chen CK, Ooi FK, Abdullah MR, Chan KL (2010) Effects of Eurycoma longifolia Jack supplementation on recreational athletes endurance running capacity and physiological responses in the heat. Int J Appl Sport Sci 22(2):1–19

    Google Scholar 

  • Muhamad AS, Chen KC, Ooi FK, Abdullah MR (2012) Eurycoma longifolia Jack, medicinal properties and its effect on endurance exercise performance. Asian J Exerc Sport Sci 6(1):39–43

    Google Scholar 

  • Nadia ME, Shuid AN (2013) Combined effects of Eurycoma longifolia and calcium on bone metabolism of orchidectomised male rats. Res Updates Med Sci 1(1):7–12

    Google Scholar 

  • National Institute of Medicinal Materials (NIMM) (2004) The medicinal plants and animals in Vietnam, vol 1. Science and Technology Publishing House, Hanoi, pp 116–118

    Google Scholar 

  • Nguyen NS, Bhatnagar S, Polonsky J, Vuilhorgne M, Prangé T, Pascard C (1982) Structure of laurycolactone A and B, new C18-quassinoids from Eurycoma longifolia and revised structure of eurycomalactone (X-ray analysis). Tetrahedron Lett 23(49):5159–5162

    Article  Google Scholar 

  • Nurhanan MY, Azimahtol Hawariah LP, Azizol AK, Chang YS, Mohtar M, Subramaniam V, Yunos NM (2002) Cytotoxicity studies of Eurycoma longifolia extracts against a panel of human cancer cell lines. In: Towards modernisation of research and technology in herbal industries. Proceedings of the seminar on medicinal and aromatic plants, 24–25 July 2001. Forest Research Institute Malaysia (FRIM), pp 124–127

    Google Scholar 

  • Nurhanan MY, Asiah O, Rafedah A, Mohd Ilham A, Anee Suryani S, Mohd Radzi A (2004) Protein and chemical fingerprints of different plant parts of E. longifolia. Poster presented at the 3rd Malaysia-MIT Biotechnology Partnership Programme (MMBPP) symposium, Kuala Lumpur, 27–28 July 2004

    Google Scholar 

  • Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA (2005) Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res 19(11):994–996

    Article  CAS  PubMed  Google Scholar 

  • Pan Y, Tiong KH, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Ong CE (2013) Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro. J Nat Med 68(2):402–406

    Article  PubMed  CAS  Google Scholar 

  • Panjaitan RQP, Handharyani E, Chairul, Manalu W (2013) Hepatoprotective activity of Eurycoma longifolia Jack. Root. Indian J Tradit Knowl 12(2):225–230

    Google Scholar 

  • Park S, Nhiem NX, Kiem PV, Minh CV, Tai BH, Kim N, Yoo HH, Song JH, Ko HJ, Kim SH (2014) Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia. Bioorg Med Chem Lett 24(16):3835–3840

    Article  CAS  PubMed  Google Scholar 

  • Qinna N, Taha H, Matalka KZ, Badwan AA (2009) A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals. J Impot Res 21(5):315–320

    Article  CAS  Google Scholar 

  • Rahmalia A, Ezyanti RR, Iriawati (2011) A qualitative and quantitative evaluation of terpenoid and alkaloid in root and stem of Pasak Bumi (Eurycoma longifolia Jack). J Matematik Sains 16(1):49–52

    Google Scholar 

  • Ramli R, Khamis MF, Shuid AN (2012) Bone micro-CT Assessments in an orchidectomised rat model supplemented with Eurycoma longifolia. Evid Based Complement Alternat Med 2012:501858

    Article  PubMed Central  PubMed  Google Scholar 

  • Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I (2012) Combined effects of Eurycoma longifolia and testosterone on androgen-deficient osteoporosis in a male rat model. Evid Based Complement Alternat Med 2012:872406

    Article  PubMed Central  PubMed  Google Scholar 

  • Salman SA, Amrah S, Wahab MS, Ismail Z, Ismail R, Yuen KH, Gan SH (2010) Modification of propranolol’s bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 35(6):691–696

    Article  CAS  PubMed  Google Scholar 

  • Sambandan TG, Ong BK, Norhaniza A, Mohd Puad A, Rha CK (2004) Quantitative measurement of chemical or bioactive constituents of Eurycoma longifolia (Tongkat Ali). Poster presented at Herbal Asia 2004, Kuala Lumpur, 25–28 March 2004

    Google Scholar 

  • Sambandan TG, Rha CK, Kadir AA, Aminudim N, Mohammed Saad J (2006) Sexual dysfunction, male infertility; root extract; topical application. US Patent 7132117 B2

    Google Scholar 

  • Satayavivad J, Soonthornchareonnon N, Somanabadhu A, Thebtaranonth Y (1998) Toxicological and antimalarial activity of eurycomalactone and Eurycoma longifolia Jack extracts in mice. Tha J Phytopharm 5:14–27

    Google Scholar 

  • Shafiqul Islam AKM, Ismail Z, Saad B, Othman AR, Ahmad MN, Md Shakaff AY (2006) Correlation studies between electronic nose response and headspace volatiles of Eurycoma longifolia extracts. Sensor Actuat B Chem 120:245–251

    Google Scholar 

  • Sholikhah EN, Wijayanti MA, Nurani LH, Mustofa J (2008) Stage specificity of pasak bumi root (Eurycoma longifolia Jack) isolate on Plasmodium falciparum cycles. Med J Malaysia 63(Suppl A):98–99

    PubMed  Google Scholar 

  • Shuid AN, Abu Bakar MF, Abdul Shukor TA, Muhammad N, Mohamed N, Soelaiman IN (2011) The anti-osteoporotic effect of Eurycoma longifolia in aged orchidectomised rat model. Aging Male 14(3):150–154

    Article  CAS  PubMed  Google Scholar 

  • Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN (2012) Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med 12:152

    Article  PubMed Central  PubMed  Google Scholar 

  • Siregar LAM, Boey PL, Chan KL (2004) Effect of cell source and pH of culture medium on the production of canthin-6-one alkaloids from the cell cultures of Tongkat Ali (Eurycoma longifolia Jack). J Plant Biotechnol 6:125–130

    Google Scholar 

  • Siregar LAM, Boey PL, Chan KL (2009) Effects of medium constituents on growth and canthinone accumulation in cell suspension cultures of Eurycoma longifolia Jack. Hayati J Biosci 16(2):69–77

    Article  Google Scholar 

  • Solomon MC, Erasmus N, Henkel RR (2014) In vivo effects of Eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat. Andrologia 46(4):339–348

    Article  CAS  PubMed  Google Scholar 

  • Sriwilaijaroen N, Kondo S, Nanthasri P, Auparakkitanon S, Suzuki Y, Wilairat P (2010) Antiplasmodial effects of Brucea javanica (L.) Merr. and Eurycoma longifolia Jack extracts and their combination with chloroquine and quinine on Plasmodium falciparum in culture. Trop Med Health 38(2):61–68

    Article  Google Scholar 

  • Tada H, Yasuda F, Otani K, Doteuchi M, Ishihara Y, Shiro M (1991) New antiulcer quassinoids from Eurycoma longifolia. Eur J Med Chem 26(3):345–349

    Article  CAS  Google Scholar 

  • Tajul Ariff AS, Soelaiman IN, Pramanik J, Shuid AN (2012) Effects of Eurycoma longifolia on testosterone level and bone structure in an aged orchidectomised rat model. Evid Based Complement Alternat Med 2012:818072

    Article  PubMed Central  PubMed  Google Scholar 

  • Talbot SM (2007) Maintaining anabolic hormone profile during weight loss and intense exercise. US Patent 20070224302 A1

    Google Scholar 

  • Talbott SM, Talbott JA, George A, Pugh M (2013) Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sport Nutr 10(1):28

    Article  Google Scholar 

  • Tambi MI (2006) Eurycoma longifolia Jack, a potent adaptogen in the form of water soluble extract with the effects of maintaining mens’ health. Asian J Androl 8(Sup1):49–50

    Google Scholar 

  • Tambi MI, Imran MK (2010) Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl 12(3):376–380

    Article  PubMed  Google Scholar 

  • Tambi MI, Imran MK, Henkel RR (2012) Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 44(Suppl 1):226–230

    Article  PubMed  CAS  Google Scholar 

  • Tan S, Yuen KH, Chan KL (2002) HPLC analysis of plasma 9-methoxycanthin-6-one from Eurycoma longifolia and its application in a bioavailability/pharmacokinetic study. Planta Med 68(4):355–358

    Article  CAS  PubMed  Google Scholar 

  • Tee TT, Azimahtol HLP (2005) Induction of apoptosis by Eurycoma longifolia Jack extracts. Anticancer Res 25(3B):2205–2213

    PubMed  Google Scholar 

  • Tee TT, Cheah YH, Hawariah LP (2007) F16, a fraction from Eurycoma longifolia Jack extract, induces apoptosis via a caspase-9-independent manner in MCF-7 cells. Anticancer Res 27(5A):3425–30

    PubMed  Google Scholar 

  • Teh CH, Teoh SC, Yeap CS, Chan KL, Fun HK (2009) 4,5,7,8,17-Penta-hydr-oxy-14,18-dimethyl-6-methyl-ene-3,10-dioxapenta-cyclo-[9.8.0.0.0.0]nona-dec-14-ene-9,16-dione methanol solvate dihydrate. Acta Crystallogr Sect E Struct Rep Online 65(Pt 4):o898-9

    PubMed  Google Scholar 

  • Teh CH, Morita H, Shirota O, Chan KL (2010) 2, 3-Dehydro-4α-hydroxylongilactone, a novel quassinoid and two known phenyl propanoids from Eurycoma longifolia Jack. Food Chem 120(3):794–798

    Google Scholar 

  • Teh CH, Abdulghani M, Morita H, Shiro M, Hussin AH, Chan KL (2011a) Comparative X-ray and conformational analysis of a new crystal of 13α,21-dihydroeurycomanone with eurycomanone from Eurycoma longifolia and their anti-estrogenic activity using the uterotrophic assay. Planta Med 77(2):128–132

    Article  CAS  PubMed  Google Scholar 

  • Teh CH, Murugaiyah V, Chan KL (2011b) Developing a validated liquid chromatography-mass spectrometric method for the simultaneous analysis of five bioactive quassinoid markers for the standardization of manufactured batches of Eurycoma longifolia Jack extract as antimalarial medicaments. J Chromatogr A 1218(14):1861–1877

    Article  CAS  PubMed  Google Scholar 

  • Tran TVA, Maliner C, Schwaiger S, Atanasov A, Heiss EH, Dirsch VM, Stuppner H (2014) NF-kB-inhibitors from Eurycoma longifolia. J Nat Prod 77:483–488

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Tzar M, Hamidah Y, Hartini M, Marianayati M, Nazrun A (2011) The antibacterial or antifungal effects of Eurycoma longifolia root extract. Internet J Herb Plant Med 1:1

    Google Scholar 

  • Udani JK, Geroge AA, Musthapa M, Pakdaman M, Abas A (2014) Effects of a proprietary freeze-dried water extract of Eurycoma longifolia (Physta) and Polygonum minus on sexual performance and well-being in men: a randomized, double-blind, placebo-controlled study. Evid Based Complement Alternat Med 2014:179529

    Article  PubMed Central  PubMed  Google Scholar 

  • Ueda JY, Tezuka Y, Banskota AH, Le Tran Q, Tran QK, Harimaya Y, Saiki I, Kadota S (2002) Antiproliferative activity of Vietnamese medicinal plants. Biol Pharm Bull 25(6):753–760

    Article  CAS  PubMed  Google Scholar 

  • Ulbricht C, Conquer J, Flanagan K, Isaac R, Rusie E, Windsor RC (2013) An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration. J Diet Suppl 10(1):54–83

    Article  CAS  PubMed  Google Scholar 

  • Wahab NA, Mokhtar NM, Halim WN, Das S (2010) The effect of Eurycoma longifolia Jack on spermatogenesis in estrogen-treated rats. Clinics (Sao Paulo) 65(1):93–98

    Article  Google Scholar 

  • Wernsdorfer WH, Ismail S, Chan KL, Congpuong K, Wernsdorfer G (2009) Activity of Eurycoma longifolia root extract against Plasmodium falciparum in vitro. Wien Klin Wochenschr 121(Suppl 3):23–26

    Article  PubMed  Google Scholar 

  • Wong PF, Cheong WF, Shu MH, Teh CH, Chan KL, AbuBakar S (2012) Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Phytomedicine 19(2):138–144

    Article  CAS  PubMed  Google Scholar 

  • Yee KM, Zulkawi N, Choudhary VK, Choudhary YK (2014) Evaluation of the genotoxicity of Eurycoma longifolia aqueous extract (Physta®) using in vitro ames test and in vivo mammalian micronucleus test. Int J Pharm Pharm Sci 6(4):652–657

    Google Scholar 

  • Yusuf H, Mustafa, Wijayanti MA, Susidarti RA, Asih PBS, Suryawati S (2013) A new quassinoid of four isolated compounds from extract Eurycoma longifolia Jack roots and their in-vitro antimalarial activity. Int J Res Pharm Biomed Sci 4(3):728–734

    CAS  Google Scholar 

  • Zakaria Y, Rahmat A, Pihie AH, Abdullah NR, Houghton PJ (2009) Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53. Cancer Cell Int 9:16

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Zanoli P, Zavatti M, Montanari C, Baraldi M (2009) Influence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats. J Ethnopharmacol 126(2):308–313

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Yang D, Xie J, Ran HL, Mend DL, Li X (2014) Isolation and identification of chemical constituents from Eurycoma longifolia Jack. J Shenyang Pharm Univ 31(1):9–12

    Google Scholar 

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Lim, T.K. (2016). Eurycoma longifolia . In: Edible Medicinal and Non-Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-319-26062-4_19

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