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l-Arginine and Its Use in Ameliorating Cryptosporidium parvum Infection in Undernourished Children

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L-Arginine in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

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Abstract

Crysptosporidiosis has been associated with persistent diarrhea and growth faltering (even without overt diarrhea) in children living in endemic areas of malnutrition and enteric infections in the developing world. The treatment is still unsatisfactory and therefore nutritional interventions are an attractive way to ameliorate the disease burden, especially in undernourished children. Herewith, we discuss the benefits of arginine supplementation to improve C. parvum infection outcomes in murine models. Clinical studies are warranted to confirm these findings, which may potentially benefit children at risk in the developing world.

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Acknowledgment

Authors would like to thank Carlos C. Câmara for manuscript edition and figures’ preparation.

Author information

Authors and Affiliations

  1. Laboratory of Biology of Tissue Healing, Federal University of Ceara, School of Medicine, Rua Cel. Nunes de Melo, 1350, 60430-270, Fortaleza, Ceará, Brazil

    Reinaldo Barreto Oriá DVM, PhD, Orleâncio Gomes Ripardo de Azevedo PhD & Theídes Batista Carneiro MSc

  2. Department of Physiology and Pharmacology, Laboratory of Infectious Diseases, Federal University of Ceara, School of Medicine, Rua Cel. Nunes de Melo, 1350, 60430-270, Fortaleza, Ceará, Brazil

    Aldo Ângelo Lima MD, PhD

  3. Division of Infectious Diseases and International Health, Center for Global Health, University of Virginia, School of Medicine, Carter Harrison Building, MR-6, room 2526, 345 Crispell Drive, 22908, Charlottesville, VA, USA

    Richard L. Guerrant MD

Authors
  1. Reinaldo Barreto Oriá DVM, PhD
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  2. Orleâncio Gomes Ripardo de Azevedo PhD
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  3. Theídes Batista Carneiro MSc
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  4. Aldo Ângelo Lima MD, PhD
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  5. Richard L. Guerrant MD
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Corresponding authors

Correspondence to Reinaldo Barreto Oriá DVM, PhD or Richard L. Guerrant MD .

Editor information

Editors and Affiliations

  1. Faculty of Science & Technology Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department Nutrition and Dietetics Nutritional Sciences Division School of Biomedical & Health Sciences, King’s College London, London, United Kingdom

    Victor R. Preedy

  3. Nutritional Sciences Research Division Faculty of Life Science and Medicine, King’s College London, London, United Kingdom

    Rajkumar Rajendram

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Oriá, R.B., de Azevedo, O.G.R., Carneiro, T.B., Lima, A.Â., Guerrant, R.L. (2017). l-Arginine and Its Use in Ameliorating Cryptosporidium parvum Infection in Undernourished Children. In: Patel, V., Preedy, V., Rajendram, R. (eds) L-Arginine in Clinical Nutrition. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-26009-9_25

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  • DOI: https://doi.org/10.1007/978-3-319-26009-9_25

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-26007-5

  • Online ISBN: 978-3-319-26009-9

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