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l-Arginine and the Expression of HSP70 and p53 Proteins

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L-Arginine in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

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Abstract

l-arginine (2-amino-5-guanidinovaleric) was isolated in 1886 from lupin seedlings. Nine years later, it was also found in animal tissues. Examinations into its function and biochemical structure started in the 1930s. Since then, l-arginine has been described to be involved in numerous biochemical pathways and metabolic processes. For example, in the liver, arginine plays a role in the urea cycle for the removal of ammonia from the body. It is also a substrate for the biological synthesis of creatine (a precursor of creatinine) [Wys and Kaddurah-Daouk (Physiol Rev 80:1107–1113, 2000)]. Although it can be synthesised endogenously, there are some conditions in which arginine cannot be synthesised adequately to meet metabolic demands, such as a consequence of physical injuries or renal insufficiency [Flynn et al. (Biomed Pharmather 56:427–438, 2002)]. In other words, it can act as a conditionally essential amino acid.

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Author information

Authors and Affiliations

  1. Department of Histology and Embryology, Medical University in Lublin, Lublin, Poland

    Agnieszka Pedrycz MD, PhD

  2. Diabetes and Nutritional Sciences, School of Medicine, King’s College London, London, UK

    Victor R. Preedy

Authors
  1. Agnieszka Pedrycz MD, PhD
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  2. Victor R. Preedy
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Correspondence to Agnieszka Pedrycz MD, PhD .

Editor information

Editors and Affiliations

  1. Faculty of Science & Technology Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department Nutrition and Dietetics Nutritional Sciences Division School of Biomedical & Health Sciences, King’s College London, London, United Kingdom

    Victor R. Preedy

  3. Nutritional Sciences Research Division Faculty of Life Science and Medicine, King’s College London, London, United Kingdom

    Rajkumar Rajendram

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Pedrycz, A., Preedy, V.R. (2017). l-Arginine and the Expression of HSP70 and p53 Proteins. In: Patel, V., Preedy, V., Rajendram, R. (eds) L-Arginine in Clinical Nutrition. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-26009-9_2

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  • DOI: https://doi.org/10.1007/978-3-319-26009-9_2

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-26007-5

  • Online ISBN: 978-3-319-26009-9

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