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Sex Steroids and Aging Bone

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Osteoporosis in Older Persons

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Abstract

Sex steroid hormones decline with increasing age in both men and women and this decline may contribute to important sequels of aging including osteoporosis. Earlier studies of sex hormones were limited by use of assays that lacked sufficient sensitivity especially for measuring very low levels of estradiol (E2) in older women. E2 plays a key role in the maintenance of skeletal integrity in both men and women. Men and women with lower E2 have low bone mineral density, experience faster rates of bone loss and have fractures. The relationship of testosterone to skeletal health is less clear. Most studies show that higher sex hormone binding globulin have a higher risk of fractures. However, a combination of sex hormones and other biomarkers may be optimal in identifying effects on bone health.

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Authors and Affiliations

  1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA

    Jane A. Cauley DrPH

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  1. Jane A. Cauley DrPH
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Correspondence to Jane A. Cauley DrPH .

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  1. Australian Institute for Musculoskeletal Science, The University of Melbourne and Western Health, Saint Albans, Victoria, Australia

    Gustavo Duque

  2. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

    Douglas P. Kiel

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Cauley, J.A. (2016). Sex Steroids and Aging Bone. In: Duque, G., Kiel, D. (eds) Osteoporosis in Older Persons. Springer, Cham. https://doi.org/10.1007/978-3-319-25976-5_5

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  • DOI: https://doi.org/10.1007/978-3-319-25976-5_5

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