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Osteoporosis in Older Persons pp 23–42Cite as

Aging and Bone

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Abstract

This chapter will provide a general overview of the aging process followed by the potential effect that aging may have in bone biology. Three important aspects will be considered: decreased number of osteoblasts, increasing adipogenesis and significant osteoblast/osteocytes apoptosis during the aging process in bone. Other aspects of bone aging has been addressed in recent reviews [1, 2].

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Authors and Affiliations

  1. Center for Stem Cell Research and Regenerative Medicine and Departments of Medicine, Structural and Cellular Biology, and Surgery, Tulane University School of Medicine, New Orleans, LA, 70112, USA

    Jeffrey M. Gimble MD, PhD

  2. LaCell LLC, New Orleans, LA, USA

    Jeffrey M. Gimble MD, PhD

  3. Ubiquitin Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 70808, USA

    Z. Elizabeth Floyd PhD

  4. Department of Endocrinology and Metabolism, University Hospital of Odense, Odense, Denmark

    Moustapha Kassem PhD

  5. Department of Anatomy, Stem Cell Unit, King Saud University, Riyadh, Saudi Arabia

    Moustapha Kassem PhD

  6. Business Development and Licensing, Department of Neuroscience, Janssen Pharmaceuticals Companies of Johnson & Johnson, Titusville, NJ, 08560, USA

    Mark E. Nuttall PhD

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Correspondence to Jeffrey M. Gimble MD, PhD .

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  1. Australian Institute for Musculoskeletal Science, The University of Melbourne and Western Health, Saint Albans, Victoria, Australia

    Gustavo Duque

  2. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

    Douglas P. Kiel

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Gimble, J.M., Floyd, Z.E., Kassem, M., Nuttall, M.E. (2016). Aging and Bone. In: Duque, G., Kiel, D. (eds) Osteoporosis in Older Persons. Springer, Cham. https://doi.org/10.1007/978-3-319-25976-5_2

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