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Osteoporosis in Older Persons pp 1–21Cite as

Biology of Bone

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Abstract

Bone is the main component of the skeleton, together with connecting tissues including cartilage, ligaments and tendons, providing mechanical and structural support for the remaining organs and systems in the body. This mechanical and structural support function is indispensable for life, both during the growth and development period as well as during adult life. However, bone also provides the unique architecture and microenvironment that preserve the niches which maintain immature stem cells. This niche aspect of bone is an inadequately recognized function, although an essential one, since stem cells are required for tissue repair and regeneration during adult life. In addition to providing mechanical support, bone contains and supports the main reservoir of cells needed to sustain tissue integrity and function throughout our lives. Thus, understanding how bone is made and maintained during life is central to developing adequate strategies to preserve a healthy skeleton as we age, so that proper mechanical support, structural integrity and tissue repair capacity are maintained.

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Authors and Affiliations

  1. Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA

    Guy A. Howard PhD

  2. Geriatric Research, Education and Clinical Center, and Research Service, Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, USA

    Guy A. Howard PhD & Paul C. Schiller PhD

  3. Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, 33136, FL, USA

    Paul C. Schiller PhD

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  1. Guy A. Howard PhD
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  2. Paul C. Schiller PhD
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Correspondence to Paul C. Schiller PhD .

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Editors and Affiliations

  1. Australian Institute for Musculoskeletal Science, The University of Melbourne and Western Health, Saint Albans, Victoria, Australia

    Gustavo Duque

  2. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

    Douglas P. Kiel

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Howard, G.A., Schiller, P.C. (2016). Biology of Bone. In: Duque, G., Kiel, D. (eds) Osteoporosis in Older Persons. Springer, Cham. https://doi.org/10.1007/978-3-319-25976-5_1

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  • DOI: https://doi.org/10.1007/978-3-319-25976-5_1

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