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IBD Diagnosis and Evaluation

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The ASCRS Textbook of Colon and Rectal Surgery

Abstract

The diagnosis and evaluation of ulcerative colitis and Crohn’s disease is critically important to provide appropriate patient care. Familiarity with modes of clinical presentation allows the clinician to promptly select the most efficient combination of tests. Knowledge of histologic findings of ulcerative colitis and Crohn’s disease facilitates discussion with other physicians of the care team and tailors specific medical and surgical therapies. Serologic tests such as ASCA, pANCA, and fecal markers such as calprotectin are increasingly becoming utilized for diagnosis and treatment effectiveness monitoring. Technologic advances in endoscopy are dramatically altering the usefulness of these already critically valuable tools. High definition images, chromoendoscopy, confocal laser endomicroscopy, and double balloon enteroscopy add to the ability to diagnose and treat. Similar advances in radiology are revolutionizing the care of the IBD patient as capsule endoscopy, computerized tomography and computerized tomography enterography, magnetic resonance imaging, and magnetic resonance enterography provide previously unimagined ability to visualize disease.

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References

  1. Baron JH. Inflammatory bowel disease up to 1932. Mt Sinai J Med N Y. 2000;67(3):174–89.

    CAS  Google Scholar 

  2. Hale-White W. On simple ulcerative colitis and other rare incidental ulcers. Guys Hosp Rep. 1888;30:131–62. 3rd series.

    Google Scholar 

  3. Mummery PL. Remarks on the value of the Sigmoidoscope in the diagnosis between primary and secondary colitis. Br Med J. 1905;2(2347):1630–1.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis: a pathologic and clinical entity. J Am Med Assoc. 1932;99(16):1323–9.

    Google Scholar 

  5. Walmsley RS, Ayres RCS, Pounder RE, Allan RN. A simple clinical colitis activity index. Gut. 1998;43(1):29–32.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Huang B, Kwan YL, Shih QD. Extraintestinal manifestations of ulcerative colitis. In: OConnor M (ed). Ulcerative Colitis—epidemiology, pathogenesis and complications [Internet]. InTech; 2011 [cited 2015 Apr 28]. Available from: http://www.intechopen.com/books/ulcerative-colitis-epidemiology-pathogenesis-and-complications/extraintestinal-manifestations-of-ulcerative-colitis

  7. Dendrinos K, Cerda S, Farraye FA. The “cecal patch” in patients with ulcerative colitis. Gastrointest Endosc. 2008;68(5):1006–7.

    PubMed  Google Scholar 

  8. Fahmy M, Shabaik A, Sandborn WJ. Cecal patch manifest as an inflammatory pseudopolyp and characterized by chromoendoscopy. Inflamm Bowel Dis. 2013;19(4):E57–8.

    PubMed  Google Scholar 

  9. Goldstein N, Dulai M. Contemporary morphologic definition of backwash ileitis in ulcerative colitis and features that distinguish it from Crohn Disease. Am J Clin Pathol. 2006;126(3):365–76.

    PubMed  Google Scholar 

  10. Bernstein CN, Shanahan F, Anton PA, Weinstein WM. Patchiness of mucosal inflammation in treated ulcerative colitis: a prospective study. Gastrointest Endosc. 1995;42(3):232–7.

    CAS  PubMed  Google Scholar 

  11. Jenkins D, Balsitis M, Gallivan S, Dixon MF, Gilmour HM, Shepherd NA, et al. Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol. 1997;50(2):93–105.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. McCormick DA, Horton LW, Mee AS. Mucin depletion in inflammatory bowel disease. J Clin Pathol. 1990;43(2):143–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Magro F, Langner C, Driessen A, Ensari A, Geboes K, Mantzaris GJ, et al. European consensus on the histopathology of inflammatory bowel disease. J Crohns Colitis. 2013;7(10):827–51.

    CAS  PubMed  Google Scholar 

  14. Goldstein NS, Leon-Armin C, Mani A. Crohn’s colitis-like changes in sigmoid diverticulitis specimens is usually an idiosyncratic inflammatory response to the diverticulosis rather than Crohn’s colitis. Am J Surg Pathol. 2000;24(5):668–75.

    CAS  PubMed  Google Scholar 

  15. Kent TH, Ammon RK, DenBesten L. Differentiation of ulcerative colitis and regional enteritis of colon. Arch Pathol. 1970;89(1):20–9.

    CAS  PubMed  Google Scholar 

  16. Price AB. Overlap in the spectrum of non-specific inflammatory bowel disease--‘colitis indeterminate’. J Clin Pathol. 1978;31(6):567–77.

    Google Scholar 

  17. Satsangi J, Silverberg MS, Vermeire S, Colombel J. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55(6):749–53.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Yu CS, Pemberton DJH, Larson D. Ileal pouch-anal anastomosis in patients with indeterminate colitis. Dis Colon Rectum. 2000;43(11):1487–96.

    CAS  PubMed  Google Scholar 

  19. Delaney CP, Remzi FH, Gramlich T, Dadvand B, Fazio VW. Equivalent function, quality of life and pouch survival rates after ileal pouch-anal anastomosis for indeterminate and ulcerative colitis. Ann Surg. 2002;236(1):43–8.

    PubMed  PubMed Central  Google Scholar 

  20. Odze RD. A contemporary and critical appraisal of “indeterminate colitis.”. Mod Pathol. 2015;28(S1):S30–46.

    Google Scholar 

  21. Turina M, Remzi FH. The J-pouch for patients with Crohn’s Disease and indeterminate colitis: (When) Is it an option? J Gastrointest Surg. 2014;18(7):1343–4.

    PubMed  Google Scholar 

  22. Cioffi M, Rosa AD, Serao R, Picone I, Vietri MT. Laboratory markers in ulcerative colitis: current insights and future advances. World J Gastrointest Pathophysiol. 2015;6(1):13–22.

    Google Scholar 

  23. Joossens S, Reinisch W, Vermeire S, Sendid B, Poulain D, Peeters M, et al. The value of serologic markers in indeterminate colitis: a prospective follow-up study. Gastroenterology. 2002;122(5):1242–7.

    PubMed  Google Scholar 

  24. Dendrinos KG, Becker JM, Stucchi AF, Saubermann LJ, LaMorte W, Farraye FA. Anti-Saccharomyces cerevisiae antibodies are associated with the development of postoperative fistulas following ileal pouch-anal anastomosis. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2006;10(7):1060–4.

    Google Scholar 

  25. Fleshner P, Vasiliauskas E, Kam L, Fleshner N, Gaiennie J, Abreu-Martin M, et al. High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis. Gut. 2001;49(5):671–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Lehmann FS, Burri E, Beglinger C. The role and utility of faecal markers in inflammatory bowel disease. Therap Adv Gastroenterol. 2015;8(1):23–36.

    Google Scholar 

  27. Abraham BP, Kane S. Fecal markers: calprotectin and Lactoferrin. Gastroenterol Clin North Am. 2012;41(2):483–95.

    PubMed  Google Scholar 

  28. Meuwis M-A, Vernier-Massouille G, Grimaud JC, Bouhnik Y, Laharie D, Piver E, et al. Serum calprotectin as a biomarker for Crohn’s disease. J Crohns Colitis. 2013;7(12):e678–83.

    PubMed  Google Scholar 

  29. Van Rheenen PF, Van de Vijver E, Fidler V. Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis. BMJ [Internet]. 2010 [cited 2015 Apr 20];341. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904879/

  30. Pineton de Chambrun G, Peyrin-Biroulet L, Lémann M, Colombel J-F. Clinical implications of mucosal healing for the management of IBD. Nat Rev Gastroenterol Hepatol. 2010;7(1):15–29.

    PubMed  Google Scholar 

  31. Røseth AG, Aadland E, Grzyb K. Normalization of faecal calprotectin: a predictor of mucosal healing in patients with inflammatory bowel disease. Scand J Gastroenterol. 2004;39(10):1017–20.

    PubMed  Google Scholar 

  32. Louis E, Mary J-Y, Vernier-Massouille G, Grimaud J-C, Bouhnik Y, Laharie D, et al. Maintenance of remission among patients with Crohn’s disease on antimetabolite therapy after infliximab therapy is stopped. Gastroenterology. 2012;142(1):63–70. e5.quiz e31.

    CAS  PubMed  Google Scholar 

  33. Ho GT, Lee HM, Brydon G, Ting T, Hare N, Drummond H, et al. Fecal calprotectin predicts the clinical course of acute severe ulcerative colitis. Am J Gastroenterol. 2009;104(3):673–8.

    CAS  PubMed  Google Scholar 

  34. Orlando A, Modesto I, Castiglione F, Scala L, Scimeca D, Rispo A, et al. The role of calprotectin in predicting endoscopic post-surgical recurrence in asymptomatic Crohn’s disease: a comparison with ultrasound. Eur Rev Med Pharmacol Sci. 2006;10(1):17–22.

    CAS  PubMed  Google Scholar 

  35. Wright EK, Kamm MA, De Cruz P, Hamilton AL, Ritchie KJ, Krejany EO, et al. Measurement of fecal calprotectin improves monitoring and detection of recurrence of crohn’s disease after surgery. Gastroenterology [Internet]. [cited 2015 Apr 5]; Available from: http://www.sciencedirect.com/science/article/pii/S0016508515001110

  36. Vermeire S, Van Assche G, Rutgeerts P. Laboratory markers in IBD: useful, magic, or unnecessary toys? Gut. 2006;55(3):426–31.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Saverymuttu SH, Hodgson HJ, Chadwick VS, Pepys MB. Differing acute phase responses in Crohn’s disease and ulcerative colitis. Gut. 1986;27(7):809–13.

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340(6):448–54.

    CAS  PubMed  Google Scholar 

  39. Shine B, Berghouse L, Jones JE, Landon J. C-reactive protein as an aid in the differentiation of functional and inflammatory bowel disorders. Clin Chim Acta Int J Clin Chem. 1985;148(2):105–9.

    CAS  Google Scholar 

  40. Poullis AP, Zar S, Sundaram KK, Moodie SJ, Risley P, Theodossi A, et al. A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammatory bowel disorders from constipation- and diarrhoea-predominant functional bowel disorders. Eur J Gastroenterol Hepatol. 2002;14(4):409–12.

    CAS  PubMed  Google Scholar 

  41. Schoepfer AM, Beglinger C, Straumann A, Trummler M, Vavricka SR, Bruegger LE, et al. Fecal calprotectin correlates more closely with the simple endoscopic score for Crohn’s Disease (SES-CD) than CRP, blood leukocytes, and the CDAI. Am J Gastroenterol. 2009;105(1):162–9.

    PubMed  Google Scholar 

  42. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature. 2001;411(6837):603–6.

    CAS  PubMed  Google Scholar 

  43. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cézard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature. 2001;411(6837):599–603.

    CAS  PubMed  Google Scholar 

  44. Chen H, Lee A, Bowcock A, Zhu W, Li E, Ciorba M, et al. Influence of Crohn’s disease risk alleles and smoking on disease location. Dis Colon Rectum. 2011;54(8):1020–5.

    PubMed  PubMed Central  Google Scholar 

  45. Sehgal R, Berg A, Hegarty JP, Kelly AA, Lin Z, Poritz LS, et al. NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis. Dis Colon Rectum. 2010;53(11):1487–94.

    PubMed  Google Scholar 

  46. Hugot J-P, Zaccaria I, Cavanaugh J, Yang H, Vermeire S, Lappalainen M, et al. Prevalence of CARD15/NOD2 mutations in Caucasian Healthy People. Am J Gastroenterol. 2007;102(6):1259–67.

    CAS  PubMed  Google Scholar 

  47. Kostic AD, Xavier RJ, Gevers D. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology. 2014;146(6):1489–99.

    CAS  PubMed  Google Scholar 

  48. Gumaste V, Sachar DB, Greenstein AJ. Benign and malignant colorectal strictures in ulcerative colitis. Gut. 1992;33(7):938–41.

    CAS  PubMed  PubMed Central  Google Scholar 

  49. Yamazaki Y, Ribeiro MB, Sachar DB, Aufses AH, Greenstein AJ. Malignant colorectal strictures in Crohn’s disease. Am J Gastroenterol. 1991;86(7):882–5.

    CAS  PubMed  Google Scholar 

  50. Navaneethan U, Parasa S, Venkatesh PGK, Trikudanathan G, Shen B. Prevalence and risk factors for colonic perforation during colonoscopy in hospitalized inflammatory bowel disease patients. J Crohns Colitis. 2011;5(3):189–95.

    PubMed  Google Scholar 

  51. Tong JL, Feng Q, Shen J, Qiao YQ, Zheng Q, Gu Y, et al. Computed tomography enterography versus balloon-assisted enteroscopy for evaluation of small bowel lesions in Crohn’s disease. J Gastroenterol Hepatol. 2013;28(7):1180–6.

    PubMed  Google Scholar 

  52. Rondonotti E, Sunada K, Yano T, Paggi S, Yamamoto H. Double-balloon endoscopy in clinical practice: where are we now? Dig Endosc. 2012;24(4):209–19.

    PubMed  Google Scholar 

  53. Makipour K, Modiri AN, Ehrlich A, Friedenberg FK, Maranki J, Enestvedt BK, et al. Double balloon enteroscopy: effective and minimally invasive method for removal of retained video capsules. Dig Endosc Off J Jpn Gastroenterol Endosc Soc. 2014;26(5):646–9.

    Google Scholar 

  54. Rahman A, Ross A, Leighton JA, Schembre D, Gerson L, Lo SK, et al. Double-balloon enteroscopy in Crohn’s disease: findings and impact on management in a multicenter retrospective study. Gastrointest Endosc [Internet]. [cited 2015 Apr 12]; Available from: http://www.sciencedirect.com/science/article/pii/S0016510714026108

  55. Papay P, Ignjatovic A, Karmiris K, Amarante H, Miheller P, Feagan B, et al. Optimising monitoring in the management of Crohn’s disease: a physician’s perspective. J Crohns Colitis. 2013;7(8):653–69.

    PubMed  Google Scholar 

  56. De Cruz P, Kamm MA, Hamilton AL, Ritchie KJ, Krejany EO, Gorelik A, et al. Crohn’s disease management after intestinal resection: a randomised trial. Lancet. 2015;385(9976):1406–17.

    Google Scholar 

  57. Mary JY, Modigliani R. Development and validation of an endoscopic index of the severity for Crohn’s disease: a prospective multicentre study. Groupe d’Etudes Thérapeutiques des Affections Inflammatoires du Tube Digestif (GETAID). Gut. 1989;30(7):983–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  58. Daperno M, D’Haens G, Van Assche G, Baert F, Bulois P, Maunoury V, et al. Development and validation of a new, simplified endoscopic activity score for Crohn’s disease: the SES-CD. Gastrointest Endosc. 2004;60(4):505–12.

    PubMed  Google Scholar 

  59. Rutgeerts P, Geboes K, Vantrappen G, Beyls J, Kerremans R, Hiele M. Predictability of the postoperative course of Crohn’s disease. Gastroenterology. 1990;99(4):956–63.

    CAS  PubMed  Google Scholar 

  60. Blum E, Katz JA. Postoperative therapy for Crohnʼs Disease. Inflamm Bowel Dis. 2009;15(3):463–72.

    PubMed  Google Scholar 

  61. Baron JH, Connell AM, Lennard-Jones JE. Variation between observers in describing mucosal appearances in proctocolitis. Br Med J. 1964;1(5375):89–92.

    CAS  PubMed  PubMed Central  Google Scholar 

  62. Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med. 1987;317(26):1625–9.

    CAS  PubMed  Google Scholar 

  63. Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001;48(4):526–35.

    CAS  PubMed  PubMed Central  Google Scholar 

  64. Ross H, Steele SR, Varma M, Dykes S, Cima R, Buie WD, et al. Practice parameters for the surgical treatment of ulcerative colitis. Dis Colon Rectum. 2014;57(1):5–22.

    PubMed  Google Scholar 

  65. Connelly TM, Koltun WA. The cancer “Fear” in IBD patients: is it still real? J Gastrointest Surg. 2013;18(1):213–8.

    PubMed  Google Scholar 

  66. Itzkowitz SH, Present DH. Crohn’s and Colitis Foundation of America Colon Cancer in IBD Study Group. Consensus conference: colorectal cancer screening and surveillance in inflammatory bowel disease. Inflamm Bowel Dis. 2005;11(3):314–21.

    PubMed  Google Scholar 

  67. Kornbluth A, Sachar DB. Practice Parameters Committee of the American College of Gastroenterology. Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 2010;105(3):501–23. quiz 524.

    PubMed  Google Scholar 

  68. Jayaram H, Satsangi J, Chapman R. Increased colorectal neoplasia in chronic ulcerative colitis complicated by primary sclerosing cholangitis: fact or fiction? Gut. 2001;48(3):430–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  69. Itzkowitz SH, Harpaz N. Diagnosis and management of dysplasia in patients with inflammatory bowel diseases. Gastroenterology. 2004;126(6):1634–48.

    PubMed  Google Scholar 

  70. Rubin CE, Haggitt RC, Burmer GC, Brentnall TA, Stevens AC, Levine DS, et al. DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology. 1992;103(5):1611–20.

    CAS  PubMed  Google Scholar 

  71. Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, et al. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastrointest Endosc. 2015;81(3):489–501.e26.

    Google Scholar 

  72. Subramanian V, Ramappa V, Telakis E, Mannath J, Jawhari AU, Hawkey CJ, et al. Comparison of high definition with standard white light endoscopy for detection of dysplastic lesions during surveillance colonoscopy in patients with colonic inflammatory bowel disease. Inflamm Bowel Dis. 2013;19(2):350–5.

    PubMed  Google Scholar 

  73. Rutter MD, Saunders BP, Schofield G, Forbes A, Price AB, Talbot IC. Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis. Gut. 2004;53(2):256–60.

    CAS  PubMed  PubMed Central  Google Scholar 

  74. Marion JF, Waye JD, Present DH, Israel Y, Bodian C, Harpaz N, et al. Chromoendoscopy-targeted biopsies are superior to standard colonoscopic surveillance for detecting dysplasia in inflammatory bowel disease patients: a prospective endoscopic trial. Am J Gastroenterol. 2008;103(9):2342–9.

    PubMed  Google Scholar 

  75. Choi C-HR, Rutter MD, Askari A, Lee GH, Warusavitarne J, Moorghen M, et al. Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: an updated overview. Am J Gastroenterol. 2015;110:1022–34.

    Google Scholar 

  76. Dekker E, van den Broek FJ, Reitsma JB, Hardwick JC, Offerhaus GJ, van Deventer SJ, et al. Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis. Endoscopy. 2007;39(3):216–21.

    CAS  PubMed  Google Scholar 

  77. De Palma GD, Rispo A. Confocal laser endomicroscopy in inflammatory bowel diseases: dream or reality? World J Gastroenterol WJG. 2013;19(34):5593–7.

    PubMed  Google Scholar 

  78. Kiesslich R, Goetz M, Lammersdorf K, Schneider C, Burg J, Stolte M, et al. Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology. 2007;132(3):874–82.

    PubMed  Google Scholar 

  79. Van de Bruaene C, De Looze D, Hindryckx P. Small bowel capsule endoscopy: where are we after almost 15 years of use? World J Gastrointest Endosc. 2015;7(1):13–36.

    Google Scholar 

  80. Kotwal VS, Attar BM, Gupta S, Agarwal R. Should bowel preparation, antifoaming agents, or prokinetics be used before video capsule endoscopy? A systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2014;26(2):137–45.

    CAS  PubMed  Google Scholar 

  81. Park S-K, Ye BD, Kim KO, Park CH, Lee W-S, Jang BI, et al. Guidelines for video capsule endoscopy: emphasis on Crohn’s disease. Clin Endosc. 2015;48(2):128–35.

    Google Scholar 

  82. Dionisio PM, Gurudu SR, Leighton JA, Leontiadis GI, Fleischer DE, Hara AK, et al. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn’s disease: a meta-analysis. Am J Gastroenterol. 2010;105(6):1240–8.

    PubMed  Google Scholar 

  83. Pennazio M, Spada C, Eliakim R, Keuchel M, May A, Mulder C, et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2015;47(04):352–86.

    Google Scholar 

  84. Höög CM, Bark L-Å, Arkani J, Gorsetman J, Broström O, Sjöqvist U. Capsule retentions and incomplete capsule endoscopy examinations: an analysis of 2300 examinations. Gastroenterol Res Pract. 2012;2012, e518718.

    Google Scholar 

  85. Dambha F, Tanner J, Carroll N. Diagnostic imaging in Crohn’s disease: what is the new gold standard? Best Pract Res Clin Gastroenterol. 2014;28(3):421–36.

    CAS  PubMed  Google Scholar 

  86. Gianluca G, Graziella DG, Veronica DM, Cinzia L, Luigi M, Ilario DS, et al. Crohn’s Disease imaging: a review. Gastroenterol Res Pract [Internet]. 2012 [cited 2015 Apr 9];2012. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270553/

  87. Gore R, Marn C, Kirby D, Vogelzang R, Neiman H. CT findings in ulcerative, granulomatous, and indeterminate colitis. Am J Roentgenol. 1984;143(2):279–84.

    CAS  Google Scholar 

  88. Ananthakrishnan AN, McGinley EL. Treatment of intra-abdominal abscesses in Crohn’s Disease—A nationwide analysis of patterns and outcomes of care. Dig Dis Sci. 2013;58(7):2013–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  89. Minordi LM, Vecchioli A, Guidi L, Mirk P, Fiorentini L, Bonomo L. Multidetector CT enteroclysis versus barium enteroclysis with methylcellulose in patients with suspected small bowel disease. Eur Radiol. 2006;16(7):1527–36.

    PubMed  Google Scholar 

  90. Bruining DH, Siddiki HA, Fletcher JG, Sandborn WJ, Fidler JL, Huprich JE, et al. Benefit of computed tomography enterography in Crohn’s disease: effects on patient management and physician level of confidence. Inflamm Bowel Dis. 2012;18(2):219–25.

    PubMed  Google Scholar 

  91. Higgins PDR, Caoili E, Zimmermann M, Bhuket TP, Sonda PL, Manoogian B, et al. Computed tomographic enterography adds information to clinical management in small bowel Crohnʼs disease. Inflamm Bowel Dis. 2007;13(3):262–8.

    PubMed  Google Scholar 

  92. Minordi LM, Vecchioli A, Poloni G, Guidi L, De Vitis I, Bonomo L. Enteroclysis CT and PEG-CT in patients with previous small-bowel surgical resection for Crohn’s disease: CT findings and correlation with endoscopy. Eur Radiol. 2009;19(10):2432–40.

    PubMed  Google Scholar 

  93. Mao R, Gao X, Zhu Z, Feng S, Chen B, He Y, et al. CT enterography in evaluating postoperative recurrence of Crohn’s disease after ileocolic resection: complementary role to endoscopy. Inflamm Bowel Dis. 2013;19(5):977–82.

    PubMed  Google Scholar 

  94. Rodriguez P, Mendez R, Matute F, Hernandez P, Mendoza JL. Imaging Crohn disease: MR enterography. J Comput Assist Tomogr. 2014;38(2):219–27.

    PubMed  Google Scholar 

  95. Grand DJ, Guglielmo FF, Al-Hawary MM. MR enterography in Crohn’s disease: current consensus on optimal imaging technique and future advances from the SAR Crohn’s disease-focused panel. Abdom Imaging. 2015;10:1–12.

    Google Scholar 

  96. Siddiki HA, Fidler JL, Fletcher JG, Burton SS, Huprich JE, Hough DM, et al. Prospective comparison of state-of-the-Art MR Enterography and CT Enterography in Small-Bowel Crohn’s Disease. Am J Roentgenol. 2009;193(1):113–21.

    Google Scholar 

  97. Bruining DH, Bhatnagar G, Rimola J, Taylor S, Zimmermann EM, Fletcher JG. CT and MR enterography in Crohn’s disease: current and future applications. Abdom Imaging [Internet]. 2015 Jan 31 [cited 2015 Mar 4]; Available from: 10.1007/s00261-015-0360-9

  98. Kralik R, Trnovsky P, Kopáčová M. Transabdominal ultrasonography of the small bowel. Gastroenterol Res Pract. 2013;2013:1–11.

    Google Scholar 

  99. Ercole E. Role of bowel ultrasound in the management of postoperative Crohn’s disease. World J Gastrointest Pathophysiol. 2014;5(4):457.

    PubMed  PubMed Central  Google Scholar 

  100. Cammarota T, Ribaldone DG, Resegotti A, Repici A, Danese S, Fiorino G, et al. Role of bowel ultrasound as a predictor of surgical recurrence of Crohn’s disease. Scand J Gastroenterol. 2013;48(5):552–5.

    PubMed  Google Scholar 

  101. Jacene HA, Ginsburg P, Kwon J, Nguyen GC, Montgomery EA, Bayless TM, et al. Prediction of the need for surgical intervention in obstructive Crohn’s Disease by 18F-FDG PET/CT. J Nucl Med. 2009;50(11):1751–9.

    CAS  PubMed  Google Scholar 

  102. Shyn PB, Mortele KJ, Britz-Cunningham SH, Friedman S, Odze RD, Burakoff R, et al. Low-dose 18F-FDG PET/CT enterography: improving on CT enterography assessment of patients with Crohn Disease. J Nucl Med. 2010;51(12):1841–8.

    PubMed  Google Scholar 

  103. Brenner DJ, Hall EJ. Computed Tomography—An increasing source of radiation exposure. N Engl J Med. 2007;357(22):2277–84.

    CAS  PubMed  Google Scholar 

  104. Sauer CG, Kugathasan S, Martin DR, Applegate KE. Medical radiation exposure in children with inflammatory bowel disease estimates high cumulative doses. Inflamm Bowel Dis. 2011;17(11):2326–32.

    PubMed  Google Scholar 

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Philp, M.M., Ross, H.M. (2016). IBD Diagnosis and Evaluation. In: Steele, S.R., Hull, T.L., Read, T.E., Saclarides, T.J., Senagore, A.J., Whitlow, C.B. (eds) The ASCRS Textbook of Colon and Rectal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-25970-3_45

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