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Results of Treatment

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Descent of the Testis

Abstract

Operative success for cryptorchidism, defined as a testis permanently placed in the scrotum without atrophy, can be achieved for at least 90 % of testes that were originally distal to the external inguinal ring, for at least 85 % of ‘true’ inguinal (i.e. canalicular) testes and for approximately 80 % of intra-abdominal testes.There is good short-term evidence that early operation is likely to decrease the risk of the two major long-term sequelae: infertility and malignancy. However, there is little long-term evidence yet of improved prognosis for fertility and malignancy risk because of the length of time between initial treatment and ultimate result (i.e. 20 years for fertility and 30–40 years for malignancy).Nevertheless, the improved short-term outcomes for early orchidopexy less than 1 year of age suggests that further improved results should be seen in future years, as more patients having orchidopexy in early infancy reach adulthood.

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References

  1. Thorup J, Haugen S, Kollin C, et al. Surgical treatment of undescended testes. Acta Paediatr. 2007;96(5):631–7.

    Article  CAS  PubMed  Google Scholar 

  2. Clarnette TD, Rowe D, Hasthorpe S, et al. Incomplete disappearance of the processus vaginalis as a cause of ascending testis. J Urol. 1997;157(5):1889–91.

    Article  CAS  PubMed  Google Scholar 

  3. Hadziselimovic F, Herzog B. The importance of both an early orchidopexy and germ cell maturation for fertility. Lancet. 2001;358(9288):1156–7.

    Article  CAS  PubMed  Google Scholar 

  4. Capello SA, Giorgi Jr LJ, Kogan BA. Orchiopexy practice patterns in New York State from 1984 to 2002. J Urol. 2006;176(3):1180–3.

    Article  PubMed  Google Scholar 

  5. Taran I, Elder JS. Results of orchiopexy for the undescended testis. World J Urol. 2006;24(3):231–9.

    Article  PubMed  Google Scholar 

  6. Docimo SG. The results of surgical therapy for cryptorchidism: a literature review and analysis. J Urol. 1995;154(3):1148–52.

    Article  CAS  PubMed  Google Scholar 

  7. Meij-deVries A, van der Voort LM, Sijstermans K, et al. Natural course of undescended testes after inguinoscrotal surgery. J Pediatr Surg. 2013;48(12):2540–4.

    Article  PubMed  Google Scholar 

  8. Elyas R, Guerra LA, Pike J, et al. Is staging beneficial for Fowler-Stephens orchiopexy? A systematic review. J Urol. 2010;183(5):2012–8.

    Article  CAS  PubMed  Google Scholar 

  9. Kollin C, Hesser U, Ritzen EM, et al. Testicular growth from birth to two years of age, and the effect of orchidopexy at age nine months: a randomized, controlled study. Acta Paediatr. 2006;95(3):318–24.

    Article  PubMed  Google Scholar 

  10. Thorup J, Jensen CL, Langballe O, et al. The challenge of early surgery for cryptorchidism. Scand J Urol Nephrol. 2011;45(3):184–9.

    Article  CAS  PubMed  Google Scholar 

  11. Ein SH, Nasr A, Wales PW, et al. Testicular atrophy after attempted pediatric orchidopexy for true undescended testis. J Pediatr Surg. 2014;49(2):317–22.

    Article  PubMed  Google Scholar 

  12. Carson JS, Cusick R, Mercer A, et al. Undescended testes: does age at orchiopexy affect survival of the testis? J Pediatr Surg. 2014;49(5):770–3.

    Article  PubMed  Google Scholar 

  13. McIntosh LA, Scrimgeour D, Youngson GG, et al. The risk of failure after primary orchidopexy: an 18 year review. J Pediatr Urol. 2013;9(6 Pt A):759–62.

    Article  CAS  PubMed  Google Scholar 

  14. Nilsson R, Omland H, Dahl AA, et al. Early outcome of orchiopexy and analysis of predictive factors: a retrospective study from 2001 to 2010 in a Norwegian regional hospital. Scand J Urol. 2014;48(5):474–81.

    Article  PubMed  Google Scholar 

  15. Cortes D, Thorup JM, Lindenberg S. Fertility potential after unilateral orchiopexy: an age independent risk of subsequent infertility when biopsies at surgery lack germ cells. J Urol. 1996;156(1):217–20.

    Article  CAS  PubMed  Google Scholar 

  16. Rasmussen TB, Ingerslev HJ, Hostrup H. Natural history of the maldescended testis. Horm Res. 1988;30(4–5):164–6.

    Article  CAS  PubMed  Google Scholar 

  17. Werder EA, Illig R, Torresani T, et al. Gonadal function in young adults after surgical treatment of cryptorchidism. Br Med J. 1976;2(6048):1357–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Cortes D. Cryptorchidism – aspects of pathogenesis, histology and treatment. Scand J Urol Nephrol Suppl. 1998;196:1–54.

    CAS  PubMed  Google Scholar 

  19. Hadziselimovic F, Hoecht B. Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism. Klin Pediatr. 2008;220(5):302–7.

    Google Scholar 

  20. Hadziselimovic F, Hecker E, Herzog B. The value of testicular biopsy in cryptorchidism. Urol Res. 1984;12(3):171–4.

    Article  CAS  PubMed  Google Scholar 

  21. Cortes D, Thorup JM, Visfeldt J. Cryptorchidism: aspects of fertility and neoplasms. A study including data of 1,335 consecutive boys who underwent testicular biopsy simultaneously with surgery for cryptorchidism. Horm Res. 2001;55(1):21–7.

    Article  CAS  PubMed  Google Scholar 

  22. Gill B, Kogan S, Starr S, et al. Significance of epididymal and ductal anomalies associated with testicular maldescent. J Urol. 1989;142(2 Pt 2):556–8. discussion 572.

    CAS  PubMed  Google Scholar 

  23. Mollaeian M, Mehrabi V, Elahi B. Significance of epididymal and ductal anomalies associated with undescended testis: study in 652 cases. Urology. 1994;43(6):857–60.

    Article  CAS  PubMed  Google Scholar 

  24. AbouZeid AA, Mousa MH, Soliman HA, et al. Intra-abdominal testis: histological alterations and significance of biopsy. J Urol. 2011;185(1):269–74.

    Article  PubMed  Google Scholar 

  25. Lee PA, Coughlin MT. Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data. Horm Res. 2001;55(1):28–32.

    Article  CAS  PubMed  Google Scholar 

  26. Cortes D, Thorup JM, Beck BL, et al. Cryptorchidism as a caudal developmental field defect. A new description of cryptorchidism associated with malformations and dysplasias of the kidneys, the ureters and the spine from T10 to S5. APMIS. 1998;106(10):953–8.

    Article  CAS  PubMed  Google Scholar 

  27. Taskinen S, Hovatta O, Wikstrom S. Early treatment of cryptorchidism, semen quality and testicular endocrinology. J Urol. 1996;156(1):82–4.

    Article  CAS  PubMed  Google Scholar 

  28. Engeler DS, Hosli PO, John H, et al. Early orchiopexy: prepubertal intratubular germ cell neoplasia and fertility outcome. Urology. 2000;56(1):144–8.

    Article  CAS  PubMed  Google Scholar 

  29. Feyles F, Peiretti V, Mussa A, et al. Improved sperm count and motility in young men surgically treated for cryptorchidism in the first year of life. Eur J Pediatr Surg. 2014;24(5):376–80.

    PubMed  Google Scholar 

  30. Cortes D, Thorup J, Lindenberg S, et al. Infertility despite surgery for cryptorchidism in childhood can be classified by patients with normal or elevated follicle-stimulating hormone and identified at orchidopexy. BJU Int. 2003;91(7):670–4.

    Article  CAS  PubMed  Google Scholar 

  31. Thorup J, Cortes D, Petersen BL. The incidence of bilateral cryptorchidism is increased and the fertility potential is reduced in sons born to mothers who have smoked during pregnancy. J Urol. 2006;176(2):734–7.

    Article  CAS  PubMed  Google Scholar 

  32. Storgaard L, Bonde JP, Ernst E, et al. Does smoking during pregnancy affect sons’ sperm counts? Epidemiology. 2003;14(3):278–86.

    PubMed  Google Scholar 

  33. Jensen TK, Jorgensen N, Punab M, et al. Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries. Am J Epidemiol. 2004;159(1):49–58.

    Article  PubMed  Google Scholar 

  34. Lee PA, O’Leary LA, Songer NJ, et al. Paternity after unilateral cryptorchidism: a controlled study. Pediatrics. 1996;98(4 Pt 1):676–9.

    CAS  PubMed  Google Scholar 

  35. Kraft KH, Canning DA, Snyder 3rd HM, et al. Undescended testis histology correlation with adult hormone levels and semen analysis. J Urol. 2012;188(4 Suppl):1429–35.

    Article  CAS  PubMed  Google Scholar 

  36. Quinn FM. Evaluation of the scrotal testis before and after orchidopexy in experimental unilateral cryptorchidism. J Pediatr Surg. 1991;26(5):602–6.

    Article  CAS  PubMed  Google Scholar 

  37. Agarwal PK, Diaz M, Elder JS. Retractile testis – is it really a normal variant? J Urol. 2006;175(4):1496–9.

    Article  PubMed  Google Scholar 

  38. van Brakel J, Kranse R, de Muinck Keizer-Schrama SM, et al. Fertility potential in a cohort of 65 men with previously acquired undescended testes. J Pediatr Surg. 2014;49(4):599–605.

    Article  PubMed  Google Scholar 

  39. Dieckmann KP, Pichlmeier U. Clinical epidemiology of testicular germ cell tumors. World J Urol. 2004;22(1):2–14.

    Article  PubMed  Google Scholar 

  40. Manecksha RP, Fitzpatrick JM. Epidemiology of testicular cancer. BJU Int. 2009;104(9 Pt B):1329–33.

    Article  PubMed  Google Scholar 

  41. Moller H. Epidemiological studies of testicular germ cell cancer. London: Kings College; 2001.

    Google Scholar 

  42. Pike MC, Chilvers C, Peckham MJ. Effect of age at orchidopexy on risk of testicular cancer. Lancet. 1986;1(8492):1246–8.

    Article  CAS  PubMed  Google Scholar 

  43. Whitaker RH. Neoplasia in cryptorchid men. Semin Urol. 1988;6(2):107–9.

    CAS  PubMed  Google Scholar 

  44. Petersen PM, Giwercman A, Hansen SW, et al. Impaired testicular function in patients with carcinoma-in-situ of the testis. J Clin Oncol. 1999;17(1):173–9.

    CAS  PubMed  Google Scholar 

  45. Giwercman A, Grindsted J, Hansen B, et al. Testicular cancer risk in boys with maldescended testis: a cohort study. J Urol. 1987;138(5):1214–6.

    CAS  PubMed  Google Scholar 

  46. Soltanghoraee H, Pourkeramati F, Khoddami M, et al. Prevalence of carcinoma in situ in testicular biopsies of infertile Iranian men. Andrologia. 2014;46(7):726–30.

    Article  CAS  PubMed  Google Scholar 

  47. Walsh TJ, Dall’Era MA, Croughan MS, et al. Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer. J Urol. 2007;178(4 Pt 1):1440–6. discussion 1446.

    Article  PubMed  Google Scholar 

  48. Pettersson A, Richiardi L, Nordenskjold A, et al. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med. 2007;356(18):1835–41.

    Article  CAS  PubMed  Google Scholar 

  49. Swerdlow AJ, Higgins CD, Pike MC. Risk of testicular cancer in cohort of boys with cryptorchidism. BMJ. 1997;314(7093):1507–11.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  50. Puri P, O’Donnell, B. Semen analysis of patients who had orchidopexy at or after seven years of age. Lancet, 2(8619):1051–2.

    Google Scholar 

  51. Singer R, Dickerman Z, Sagiv M, Laron Z, Livni E. Endocrinological parameters and cell-mediated immunity postoperation for cryptorchidism. Arch Androl. 1988; 20(2):153–7.

    Google Scholar 

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Hutson, J.M., Thorup, J.M., Beasley, S.W. (2016). Results of Treatment. In: Descent of the Testis. Springer, Cham. https://doi.org/10.1007/978-3-319-25910-9_10

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  • DOI: https://doi.org/10.1007/978-3-319-25910-9_10

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