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Nephrolithiasis in Primary Hyperparathyroidism

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Hyperparathyroidism

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Abstract

Renal stones are common in primary hyperparathyroidism (PHPT), thought to be secondary to hypercalcemia, although correlation between biochemical factors including serum calcium levels and renal stones is inconsistent in studies. Stones in PHPT patients are associated with younger age and male gender. Renal stone risk decreases after parathyroidectomy, but probably remains elevated compared to the general population for up to 10 years. Thus parathyroid hormone (PTH) should be tested in stone formers with hypercalcemia. Among patients diagnosed with PHPT, a history of clinical stone events and/or the presence of radiologic stones is an indication for parathyroidectomy.

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Conflict of Interest

All authors state that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Urology, Mayo College of Medicine, Mayo Clinic, Rochester, MN, USA

    Johann P. Ingimarsson MD

  2. Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo College of Medicine, Mayo Clinic, Rochester, MN, USA

    John C. Lieske MD

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  1. Johann P. Ingimarsson MD
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Correspondence to John C. Lieske MD .

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Editors and Affiliations

  1. Mayo Clinic, Rochester, Minnesota, USA

    Ann E. Kearns

  2. Mayo Clinic, Rochester, Minnesota, USA

    Robert A. Wermers

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© 2016 Mayo Foundation for Medical Education and Research

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Ingimarsson, J.P., Lieske, J.C. (2016). Nephrolithiasis in Primary Hyperparathyroidism. In: Kearns, A., Wermers, R. (eds) Hyperparathyroidism. Springer, Cham. https://doi.org/10.1007/978-3-319-25880-5_3

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  • DOI: https://doi.org/10.1007/978-3-319-25880-5_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-25878-2

  • Online ISBN: 978-3-319-25880-5

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