Abstract
Ever since from establishment of Cancer Stem Cell Theories, there was a permanent, strong effort to understand differences and similarities between distinctive types of normal, and between normal and cancer stem cells. A striking distinction between embryonic and adult stem cells is achieved, and a striking distinction between normal and CSC is obvious, although the knowledge on CSCs is still very limited despite interesting results. Is Cancer a disease of stem cells? There is an extraordinary diversity within the broad category of diseases known as a cancer. The cellular markers, the signaling pathways to the nucleus, the metabolic trajectories, and genetic changes vary in different tumors. It will be necessary to figure out different CSC profiles and find the best possible targeted treatment for each particular CSC. Thus, the fact that only a few cells within the tumor, the CSCs are tumorigenic and possess metastatic phenotype has implications for both therapy and research. Despite so many levels of diagnostic and therapeutic achievements, it is still a lot of work needed to clarify this issue. The development of novel technologies, such as genetic engineering, nanotechnology, antimitochondrial cancer therapy, magnetotherapy, immunotherapeutic approaches, and remote control drug delivery systems, today portrays the field of targeted anticancer therapy as the concept which is emerging as a fantastic array of possibilities for better understanding of the stemness. This chapter will summarize the current essential and future guidelines in bioengineering necessary to understand this entity from many points of views.
The saddest aspect of life right now is that science gathers knowledge faster than society gathers wisdom.
Isaac Asimov
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Pavlovic, M., Balint, B. (2015). Summary on the Role of Bioengineering in Cancer Stem Cell Paradigm. In: Bioengineering and Cancer Stem Cell Concept. Springer, Cham. https://doi.org/10.1007/978-3-319-25670-2_12
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DOI: https://doi.org/10.1007/978-3-319-25670-2_12
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