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δ-Opioids and Neurogenesis

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Neural Functions of the Delta-Opioid Receptor

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Abstract

Opioid analgesics and endogenous opioid peptides have a wide range of physiological and behavioral effects on pain perception, mood, motor control and autonomic function. The δ-opioidergic system has been recognized as a diagnostic neuropeptide that may be directly involved in neural differentiation, maturation and protection, and may contribute to the possible recovery of emotional dysfunction. Stimulation of δ-opioid receptors of neural progenitor cells enhanced neural differentiation, maturation and protection, which could lead to anti-depressive and anti-anxiolytic effects. We suggest that the δ-opioids may be a good target for the treatment of neuropsychiatric disease.

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Abbreviations

BDNF:

Brain-derived neurotrophic factor

CNTF:

Ciliary neurotrophic factor

DAMGO:

[D-Ala2, N-Me- Phe4, Gly5-ol]-enkephalin

EAATs:

Excitatory amino acid transporters

FGFs:

Fibroblast growth factors

GDNF:

Glial-derived neurotrophic factor

GPCRs:

G-protein-coupled receptors

NGF:

Nerve growth factor

NT-3/4:

Neurotrophin-3/4

PDYN:

Prodynorphin

PENK:

Proenkephalin

POMC:

Proopiomelanocortin

SNC80:

[(+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl] -N,N-diethylbenzamide]

U50,488H:

(–)-Trans-(1S,2S)-U-50488 hydrochloride

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Authors and Affiliations

  1. Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan

    Naoko Kuzumaki Ph.D. (Associate professor) & Minoru Narita Ph.D. (Professor and chair)

  2. Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan

    Minoru Narita Ph.D. (Professor and chair)

Authors
  1. Naoko Kuzumaki Ph.D.
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  2. Minoru Narita Ph.D.
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Corresponding authors

Correspondence to Naoko Kuzumaki Ph.D. or Minoru Narita Ph.D. .

Editor information

Editors and Affiliations

  1. Univ of Texas Med Schl, Houston, Texas, USA

    Ying Xia

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Kuzumaki, N., Narita, M. (2015). δ-Opioids and Neurogenesis. In: Xia, Y. (eds) Neural Functions of the Delta-Opioid Receptor. Springer, Cham. https://doi.org/10.1007/978-3-319-25495-1_9

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