Neural Stimulation and Charge Balancing Approaches

  • Vinod Kumar Khanna


The stimulating electrodes are generally configured in monopolar and bipolar configurations. Common simulation modes are the current mode and voltage mode. The usual stimulation waveforms are either monophasic or biphasic. Charge imbalance occurs by semiconductor failure. Such imbalance may also arise from leakage currents. The main cause is cross talk between adjacent stimulating channels (sites) as well as cable failure. Positive charge balance is provided by a blocking capacitor connected in series with each electrode. This protective mechanism is used for electrical safety against fault conditions. The large capacitance value required for the blocking capacitors (sometimes a few microfarads) is realized through off-chip surface-mount components. In applications, e.g., retinal implants, the large-size blocking capacitors cannot be used. This inability is due to physical size limitations. Then, other methods for active charge balancing are resorted to. A stimulator circuit that is foolproof without off-chip blocking capacitors produces an active stimulation phase by high-frequency current switching. This phase is followed by a succeeding passive discharge phase.


Monopolar electrode Bipolar electrode DAC ADC VIC Voltage multiplier CCS VCS ChCS Charge balancing Blocking capacitor 


  1. 1.
    Scholten M, Szili-Torok T, Klootwijk P et al (2003) Comparison of monophasic and biphasic shocks for transthoracic cardioversion of atrial fibrillation. Heart 89:1032–1034CrossRefGoogle Scholar
  2. 2.
  3. 3.
    Coates E (2014) Learn about electronics: power supplies: Module 3: Switched mode power supplies. Accessed 14 Sept 2014
  4. 4.
    Simpson J, Ghovanloo M (2007) An experimental study of voltage, current, and charge controlled stimulation front-end circuitry. IEEE International Symposium on Circuits & Systems, ISCAS 2007, New Orleans, LA, 27–30 May, pp 325–328Google Scholar
  5. 5.
    Valente V, Demosthenous A, Bayford R (2012) A tripolar current-steering stimulator ASIC for field shaping in deep brain stimulation. IEEE Trans Biomed Circuits Syst 6(3):197–207CrossRefGoogle Scholar
  6. 6.
    Liu X, Demosthenous A, Donaldson N (2008) An integrated implantable stimulator that is fail-safe without off-chip blocking-capacitors. IEEE Trans Biomed Circuits Syst 2(3):231–244CrossRefGoogle Scholar
  7. 7.
    Kelly SK, Wyatt J (2004) A power-efficient voltage-based neural tissue stimulator with energy recovery. IEEE International Solid-State Circuits Conference ISSCC 2004, 17 Feb 2004, 10 pGoogle Scholar
  8. 8.
    Kelly SK, Wyatt JL Jr (2011) A power-efficient neural tissue stimulator with energy recovery. IEEE Trans Biomed Circuits Syst 5(1):20–29CrossRefGoogle Scholar
  9. 9.
    Ghovanloo M (2006) Switched-capacitor based implantable low-power wireless microstimulating systems. Proc. IEEE International Symposium on Circuits and Systems, ISCAS 2006, pp 2197–2200Google Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Vinod Kumar Khanna
    • 1
  1. 1.CSIR-Central Electronics Engineering Research InstitutePilaniIndia

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