Abstract
Implantable drug delivery devices, nondegradable reservoir or biodegradable types, have shown great prospects. These devices have revealed ostensible possibilities of advancement in several applications demanding onerous efforts in controlled and precise, highly localized liberation of decisive doses of drugs with fewer side effects and without direct medical intervention. Actively controlled devices are more propitious than passive release devices. This greater potentiality of active devices is because the drug delivery process can be controlled postimplantation and even by telemetry, involving automatic measurements and telecommunication. Dissenting from passive devices, they do not rely on the chemistry of degradation of specific materials in the premeditated region of implant. Numerous implantable drug delivery devices have been reconnoitered for use in chronic and terminal diseases. Diabetes, osteoporosis, and cancer are a few such examples.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Arps J (2013) Implantable drug delivery devices—an overview. Med Design Technol. http://www.mdtmag.com/articles/2013/07/implantable-drug-delivery-devices%E2%80%94-overview. Accessed 5 Feb 2015
Stuart A (2010) The promise of implantable drug delivery systems. Eyenet: 33–37
Maloney JM (2003) An implantable microfabricated drug delivery system. In: Proceedings of IMECE’03, 2003 ASME International Mechanical Engineering Congress and Exposition, Washington, DC, 15–21 Nov, Paper No. IMECE2003-43186, pp 115–116. doi:10.1115/IMECE2003-43186. Copyright © 2003 by ASME
Gupta H, Bhandari D, Sharma A (2009) Recent trends in oral drug delivery: a review. Recent Pat Drug Deliv Formul 3(2):162–173
Djupesland PG (2013) Nasal drug delivery devices: characteristics and performance in a clinical perspective-a review. Drug Deliv Transl Res 3(1):42–62
Patil JS, Sarasija S (2012) Pulmonary drug delivery strategies: a concise, systematic review. Lung India 29(1):44–49
Shingade GM, Aamer Q, Sabale PM (2012) Review on: recent trend on transdermal drug delivery system. J Drug Deliv Ther 2(1):66–75
Yalkowsky SH, Krzyzaniak JF, Ward GH (1998) Formulation-related problems associated with intravenous drug delivery. J Pharm Sci 87(7):787–796
Rajgor N, Patel M, Bhaskar VH (2011) Implantable drug delivery systems: an overview. Syst Rev Pharm 2(2):91–95
Siegel RA, Rathbone MJ (2012) Chapter 2: Overview of controlled release mechanisms. In: J Siepmann, RA Siegel, MJ Rathbone (eds) Fundamentals and applications of controlled release drug delivery. © Controlled Release Society, pp 19–43
Lux CDG, Mahmoud E, Joshi-Barr S (2015) Bioresponsive materials. ©2015 Regents of the University of California. http://almutairi.ucsd.edu/bioresponsive-materials. Accessed 6 Feb 2015
Solanki HK, Thakkar JH, Jani GK (2010) Recent advances in implantable drug delivery. Int J Pharm Sci Rev Res 4(3):168–177
Bhowmik D, Gopinath H, Kumar BP et al (2012) Controlled release drug delivery systems. Pharma Innovation 1(10):24–32
Japp NS (2008) Sterilization processes: what every infection control practitioner needs to know. Infect Control Res 5(1):1, 5–7
Tilton G, Kauffman M (2004) Sterilization: a review of the basics. Manag Infect Control: 66–71
Ronak K, Yatin K, Baldaniya L et al (2012) Implant-controlled release medicated formulation. Int J Pharma Chem Sci 1(1):59–66
Chung AJ, Kim D, Erickson D (2008) Electrokinetic microfluidic devices for rapid, low power drug delivery in autonomous microsystems. Lab Chip 8:330–338
Herrlich S, Spieth S, Messner S (2012) Osmotic micropumps for drug delivery. Ann Drug Deliv Rev 64(14):1617–1627
Santini JT, Cima MJ, Langer R (1999) A controlled-release microchip. Nature 397(6717):335–338
Meng E, Hoang T (2012) Micro- and nano-fabricated implantable drug-delivery systems. Ther Deliv 3(12):1457–1467
Au AK, Lai H, Utela BR et al (2011) Microvalves and micropumps for BioMEMS. Micromachines 2:179–220
Tng DJH, Hu R, Song P et al (2012) Approaches and challenges of engineering implantable microelectromechanical systems (MEMS) drug delivery systems for in vitro and in vivo applications. Micromachines 3:615–631
Gultepe E, Nagesha D, Sridhar S et al (2010) Nanoporous inorganic membranes or coatings for sustained drug delivery in implantable devices. Adv Drug Deliv Rev 62:305–315
Stevenson EL, Santini JT, Langer R (2012) Reservoir-based drug delivery systems utilizing microtechnology. Adv Drug Deliv Rev 64(14):1590–1602
Desai TA, Chu WH, Tu JK et al (1998) Microfabricated immunoisolating biocapsules. Biotech Bioeng 57(1):118–120
Rahimi S, Sarraf EH, Wong GK et al (2011) Implantable drug delivery device using frequency controlled wireless hydrogel microvalves. Biomed Microdevices 13(2):267–277
Pal K, Banthia AK, Majumdar DK (2009) Polymeric hydrogels: characterization and biomedical applications—a mini review. Design Monomers Polym 12:197–220
Chung AJ, Huh YS, Erickson D (2009) A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release. Biomed Microdevices 11(4):861–867
Pirmoradi FN, Jackson JK, Burt HM et al (2011) On-demand controlled release of docetaxel from a battery-less MEMS drug delivery device. Lab Chip 11(16):2744–2752
Nisar A, Afzulpurkar N, Mahaisavariya B (2008) MEMS-based micropumps in drug delivery and biomedical applications. Sens Actuators B Chem 130:917–942
Reynaerts D, Peirs J, Brussel HV (1997) An implantable drug delivery system based on shape memory alloy micro-actuation. Sens Actuators A Phys 61:455–462
Teymoori MM, Abbaspour-Sani E (2005) Design and simulation of a novel electrostatic peristaltic micromachined pump for drug delivery applications. Sens Actuators A Phys 117(2):222–229
Woias P (2005) Micropumps- past, present and future prospects. Sens Actuators B Chem 105:28–38
Bourouina T, Bosseboeuf A, Grandchamp JP (1997) Design and simulation of an electrostatic micropump for drug-delivery applications. J Micromech Microeng 7(3):186–188
Van Lintel HTG, Van de Pol FCM, Bouwstra SA (1988) A piezoelectric micropump based on micromachining of silicon. Sens Actuators A Phys 15:153–168
Debiotech. ©2014—Debiotech S.A.—Switzerland. http://www.debiotech.com/newsite/page/index.php?page=product_01&id=1&id_prod=0. Accessed 5 Feb 2015
Li PY, Shih J, Lo R et al (2008) An electrochemical intraocular drug delivery device. Sens Actuators A Phys 143(1):41–48
Gensler H, Sheybani R, Li PY et al (2012) An implantable MEMS micropump system for drug delivery in small animals. Biomed Microdevices 14(3):483–496
Abhari F, Jaafar H, Yunus NAM (2012) A comprehensive study of micropumps technologies. Int J Electrochem Sci 7:9765–9780
Cooney CG, Towe BC (2004) A thermopneumatic dispensing micropump. Sens Actuators A Phys 116(3):519–524
Spieth S, Schumacher A, Holtzman T et al (2012) An intra-cerebral drug delivery system for freely moving animals. Biomed Microdevices 14(5):799–809
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Khanna, V.K. (2016). Drug Delivery Implants. In: Implantable Medical Electronics. Springer, Cham. https://doi.org/10.1007/978-3-319-25448-7_23
Download citation
DOI: https://doi.org/10.1007/978-3-319-25448-7_23
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-25446-3
Online ISBN: 978-3-319-25448-7
eBook Packages: EngineeringEngineering (R0)