Abstract
Understanding the normal biodistribution and kinetics of the three most common cardiac radiopharmaceuticals (99mTc sestamibi, 99mTc tetrofosmin, 201Tl chloride) is fundamental to the practice of gamma camera-based MPI. The gamma camera instrumentation may be dedicated to imaging the heart with two small perpendicularly oriented detectors, or it may be a system with general purpose large field-of-view detectors that can be configured for SPECT MPI. During image acquisition, the perfusion data may be gated to the R-R interval of the ECG monitor to create gated SPECT images. There are many accepted SPECT MPI stress test protocols. Traditionally, patients undergo two scans, one during rest and the other after stress. Scan patterns, incidental findings, and imaging artifacts may vary considerably depending on the protocol followed. There are many sources of imaging artifacts, including patient motion, soft-tissue attenuation, filtering and windowing, and subdiaphragmatic activity.
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Oates, M.E., Sorrell, V.L. (2017). Technical Principles. In: Myocardial Perfusion Imaging - Beyond the Left Ventricle. Springer, Cham. https://doi.org/10.1007/978-3-319-25436-4_2
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