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Epigenetic Regulation of ES Cell Pluripotency Maintenance

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Epigenetics, the Environment, and Children’s Health Across Lifespans

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Abstract

Epigenetic regulation plays an important role in ES cell pluripotency maintenance. Chromatin structure changes, DNA methylation, and noncoding RNAs all contribute to the epigenetic regulation of ES cell pluripotency maintenance. They will be described in detail in this chapter.

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Authors and Affiliations

  1. Shanghai Institutes for Biological Sciences, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, Room 1211, Shanghai, 200031, China

    Ping Hu Ph.D.

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  1. Pfeiffer University, Morrisville, North Carolina, USA

    David Hollar

Abbreviations

Abbreviations

BAF:

Brahma-associated factor

CpG:

Cytosine-guanine nucleotide-rich sequence

DNMT:

DNA methyltransferase

ES Cells:

Embryonic stem cell

HP1α:

Heterochromatin protein 1α

iPS Cells:

Induced pluripotent stem cells

ICM:

Inner cell mass

INO80 chromatin remodeling complex:

A chromatin remodeling complex

lncRNA:

Long noncoding RNA

NODE:

Nanog and Oct4-associated deacetylase

ncRNA:

Noncoding RNA

NuRD:

Nucleosome remodeling and deacetylase

c-Myc:

Oncogene master regulator

PcG:

Polycomb group protein

TrxG:

Trithorax group protein

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Hu, P. (2016). Epigenetic Regulation of ES Cell Pluripotency Maintenance. In: Hollar, D. (eds) Epigenetics, the Environment, and Children’s Health Across Lifespans. Springer, Cham. https://doi.org/10.1007/978-3-319-25325-1_9

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