Abstract
Childhood obesity is a preventable disease affecting millions of youth in the United States. Its prevalence is spreading throughout the world and has been declared one of the most serious health challenges of the twenty-first century by the World Health Organization (2015). The role of epigenetics in child obesity remains to be determined, although several twin and other research studies implicate methylation and chromatin remodeling of gene regions that have been associated with obesity. While it is known that the environment affects the expression of certain genes associated with excess adiposity, the nature of the cause–effect relationship is not yet clear.
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References
Amarasekera, M., Prescott, S. L., & Palmer, D. J. (2013). Nutrition in early life, immune-programming and allergies: The role of epigenetics. Asian Pacific Journal of Allergy and Immunology, 31(3), 175–182.
Bollati, V., & Baccarelli, A. (2010). Environmental epigenetics. Heredity, 105(1), 105–112. http://dx.doi.org/10.1038/hdy.2010.2.
Buchbinder, D., Nadeau, K., & Nugent, D. (2011). Monozygotic twin pair showing discordant phenotype for X-linked thrombocytopenia and Wiskott–Aldrich syndrome: A role for epigenetics? Journal of Clinical Immunology, 31(5), 773–777.
Campbell, T. C., & Campbell, T. M. (2006). The China Study: the most comprehensive study of nutrition ever conducted and the startling implications for diet, weight loss and long-term health. Dallas, Texas: BenBella Books.
CDC. Obesity – United States 1999-2010. MMWR 2013: 62(03);120–128 (Suppl; November 22, 2013).
Choquet, H., & Meyre, D. (2011). Genetics of obesity: What have we learned? Current Genomics, 12(3), 169–179. doi:10.2174/138920211795677895.
Dietz, W. H. (1998). Health consequences of obesity in youth: Childhood predictors of adult disease. Pediatrics, 101(3), 518–525. Retrieved from http://search.proquest.com/docview/228391080?accountid=13172.
Freedman, D. S., Dietz, W. H., Srinivasan, S. R., & Berenson, G. S. (1999). The relation of overweight to cardiovascular risk factors among children and adolescents: The bogalusa heart study. Pediatrics, 103(6), 1175–1182. Retrieved from http://search.proquest.com/docview/228372557?accountid=13172.
Freedman, D. S., Kettel, L., Serdula, M. K., Dietz, W. H., Srinivasan, S. R., & Berenson, G. S. (2005). The relation of childhood BMI to adult adiposity: The Bogalusa Heart Study. Pediatrics, 115, 22–27.
Gluckman, P. D., & Hanson, M. A. (2008). Developmental and epigenetic pathways to obesity: An evolutionary-developmental perspective. International Journal of Obesity, 32, S62–71. doi: http://dx.doi.org/10.1038/ijo.2008.240.
Gluckman, P. D., Hanson, M. A. Cooper, C., & Thornburg, K. L. (2008). Mechanisms of disease: Effect of in utero and early-life conditions on adult health and disease. The New England Journal of Medicine, 359(1), 61–73. doi: http://dx.doi.org/10.1056/NEJMra0708473.
Godfrey, K. M., Sheppard, A., Gluckman, P. D., Lillycrop, K. A., Burdge, G. C., McLean, C., Rodford, J., Slater-Jeffries, J. L., Garratt, E., Crozier, S. R., Emerald, B. S., Gale, C. R., Inskip, H. M., Cooper, C., & Hanson, M. A. (2011a, June 20). Mom’s pregnancy diet linked to DNA changes, child's obesity. Retrieved May 18, 2015, from http://www.environmentalhealthnews.org/ehs/newscience/moms-pregnancy-diet-linked-to-dna-changes-childs-obesity/
Godfrey, K. M., Sheppard, A., Gluckman, P. D., Lillycrop, K. A., Burdge, G. C., & McLean, C., et al. (2011b). Epigenetic gene promoter methylation at birth is associated with child’s later adiposity. Diabetes, 60(5), 1528–1534.
Hafekost, K., Lawrence, D., Mitrou, F., O’Sullivan, T. A., & Zubrick, S. R. (2013). Tackling overweight and obesity: Does the public health message match the science? BMC Medicine, 11, 41.
Hall, J. G. (2014). Epigenetics: What does it mean for paediatric practice? Paediatrics and Child Health, 19(1), 27–30.
Hall, K. D., Sacks, G., Chandramohan, D., Chow, C. C., Wang, Y. C., Gortmaker, S. L., & Swinburn, B. A. (2011). Quantification of the effect of energy imbalance on bodyweight. Lancet, 378(9793), 826–837. PMID:21872751.
Hammond, R. A., & Levine, R. (2010). The economic impact of obesity in the United States. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 3, 285–295. doi:10.2147/DMSOTT.S7384.
Huh, S. Y., Rifas-Shiman, S. L., Taveras, E. M., Oken, E., & Gillman, M. W. (2011). Timing of solid food introduction and risk of obesity in preschool-aged children. Pediatrics, 127(3), e544–e551.
Koya, D. L., & Egede, L. E. (2007). Association between length of residence and cardiovascular disease risk factors among an ethnically diverse group of United States immigrants. Journal of General Internal Medicine, 22(6), 841–846. doi:10.1007/s11606-007-0163-y.
Kuczmarski, R. J., et al. (2002). 2000 CDC growth charts for the United States: Methods and development. Vital and Health Statistics, 11(246), 1–190.
Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014). Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA, 311(8), 806–814. doi:10.1001/jama.2014.732.
Powledge, T. M. (2011). Behavioral epigenetics: How nurture shapes nature. BioScience, 61(8), 588–592.
Schwartz, M. B., & Puhl, R. (2003). Childhood obesity: A societal problem to solve. Obesity Reviews, 4(1), 57–71. doi: http://dx.doi.org/10.1046/j.1467-789X.2003.00093.x.
Shapira, N. (2008). Prenatal nutrition: A critical window of opportunity for mother and child. Women’s Health, 4(6), 639–656. http://dx.doi.org/10.2217/17455057.4.6.639.
World Health Organization. (2015). Global strategy on diet, physical activity and health. Geneva, Switzerland: World Health Organization.
Yajnik, C. S. (2010). Fetal programming of diabetes: Still so much to learn! Diabetes Care, 33(5), 1146–1148.
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Hohensee, C., Varela, T., Harris, D. (2016). Child Obesity and Epigenetics. In: Hollar, D. (eds) Epigenetics, the Environment, and Children’s Health Across Lifespans. Springer, Cham. https://doi.org/10.1007/978-3-319-25325-1_13
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DOI: https://doi.org/10.1007/978-3-319-25325-1_13
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