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Polymeric Hydrogels as Smart Biomaterials pp 73–104Cite as

Protein-Based Hydrogels

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Part of the book series: Springer Series on Polymer and Composite Materials ((SSPCM))

Abstract

Protein-based hydrogels are composed of isolated or enriched proteins from natural extracellular matrix. Inherent and controllable bioactivity makes these hydrogels promising candidates as smart biomaterials for drug delivery, tissue engineering and regenerative medicine, and other applications. Desirable characteristics for these applications include natural cell binding, cell degradable, and growth factor-binding sequences. This chapter covers the unique properties of a variety of proteins (collagen, gelatin, fibrin, silk, elastin, keratin, and decellularized, tissue-specific extracellular matrix) as well as hydrogel synthesis, fabrication, modification, and established applications. Conditions of solubility and the mechanism of the sol–gel transition are discussed. Since each protein presented undergoes self-assembly to form a gel network, gelation parameters that affect this assembly and subsequently the gel ultrastructure are specifically presented. Emerging applications and technologies for protein-based hydrogels are also briefly mentioned.

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Authors and Affiliations

  1. Biomedical Engineering, Northwestern University, Evanston, IL, USA

    Alexandra L. Rutz

  2. Materials Science and Engineering, Northwestern University, Evanston, IL, USA

    Ramille N. Shah

  3. Surgery (Transplant Division), Northwestern University, Chicago, IL, USA

    Ramille N. Shah

  4. Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, USA

    Alexandra L. Rutz & Ramille N. Shah

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  1. Department of Chemistry, ACC Wing, Indian Military Academy, Dehradun, Uttarakhand, India

    Susheel Kalia

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Rutz, A.L., Shah, R.N. (2016). Protein-Based Hydrogels. In: Kalia, S. (eds) Polymeric Hydrogels as Smart Biomaterials. Springer Series on Polymer and Composite Materials. Springer, Cham. https://doi.org/10.1007/978-3-319-25322-0_4

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