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Polysaccharide-Based Hydrogels as Biomaterials

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Polymeric Hydrogels as Smart Biomaterials

Part of the book series: Springer Series on Polymer and Composite Materials ((SSPCM))

Abstract

The ever-increasing interest to utilize renewable polysaccharide-based hydrogels as biomaterials has created renewed interest in many disciplines including biomedicine, bioengineering, pharmacy, chemistry, and materials science. The volume of literature published in this area is quite extensive as the diversity of these materials seeks novel applications. The polysaccharide-based hydrogels as smart biomaterials have attracted much interest in drug delivery, bioengineering, and electronics domain. Recent advances in micro- and nanobiotechnology have led to renewed interest for targeting drugs, genes, and other biotherapeutics like proteins, small interfering RNA (siRNA), and peptides. These applications have progressed exponentially due to their similarities with soft tissue body components as well as being responsive to external stimuli like temperature, pH, electric and magnetic fields. This chapter covers recent developments and advances in hydrogels derived from natural polysaccharides as biomaterials.

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Abbreviations

3D:

Three-dimensional

AG:

Agarose

ATDC5:

Chondrocytic cell line

Az-chitosan:

4-azidobenzamide grafted chitosan

BMP-2:

Bone morphogenetic protein-2

bMSCs:

Bovine mesenchymal stem cells

BMSCs:

Bone marrow stem cells

BSA:

Bovine serum albumin

CG:

Carrageenan

CS:

Chitosan

CT1:

Connexin-43 carboxyl-terminus mimetic peptide

DD:

Degree of deacetylation

DMF:

Dimethyl formamide

DMSO:

Dimethyl sulphoxide

DS:

Dextran sulfate

ECM:

Extracellular matrix

EE:

Entrapment efficiency

EGFP:

Enhanced green fluorescent protein

full-IPN:

Full-interpolymeric network

GA:

Glutaraldehyde

GAGs:

Mammalian glycosaminoglycans

GAGs:

Glycosaminoglycans

G-CSF:

Granulocyte colony-stimulating factor

GFP:

Green fluorescent protein

GM-CSF:

Granulocyte-macrophage colony-stimulating factor

GRAS:

Generally recognized as safe

HA:

Hyaluronic acid

hASCs:

Human adipose-derived stem cells

hNCs:

Human nasal chondrocytes

HP:

Heparin

k-carrageenan:

Kappa-Carrageenan

MW:

Molecular weight

MYO:

Î’-galactosidase, myoglobin

NaAlg:

Sodium alginate

NPs:

Nanoparticles

PEG:

Polyethylene glycol

PLGA:

Poly(lactic-co-glycolic acid) copolymer

rhGH:

Recombinant human growth hormone

semi-IPN:

Semi-interpolymeric network

SLN:

Solid lipid nanoparticles

US-FDA:

United States Food and Drug Administration

VBL:

Visible blue light

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Acknowledgments

Authors are grateful to the Board of Research in Nuclear Science [BRNS, Grant No.: 34(1)14/35/2014-BRNS], Mumbai, India for financial support.

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Authors and Affiliations

  1. Department of Pharmaceutics, Shree Dhanvantary Pharmacy College, Near Kim Railway Station, Kim (E), Kudsad Road, Surat, Gujarat, 394110, India

    Tejraj M. Aminabhavi & Anand S. Deshmukh

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  1. Tejraj M. Aminabhavi
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  2. Anand S. Deshmukh
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Correspondence to Tejraj M. Aminabhavi .

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  1. Department of Chemistry, ACC Wing, Indian Military Academy, Dehradun, Uttarakhand, India

    Susheel Kalia

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Aminabhavi, T.M., Deshmukh, A.S. (2016). Polysaccharide-Based Hydrogels as Biomaterials. In: Kalia, S. (eds) Polymeric Hydrogels as Smart Biomaterials. Springer Series on Polymer and Composite Materials. Springer, Cham. https://doi.org/10.1007/978-3-319-25322-0_3

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