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Carboxylic Acids Plasma Membrane Transporters in Saccharomyces cerevisiae

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Yeast Membrane Transport

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 892))

Abstract

This chapter covers the functionally characterized plasma membrane carboxylic acids transporters Jen1, Ady2, Fps1 and Pdr12 in the yeast Saccharomyces cerevisiae, addressing also their homologues in other microorganisms, as filamentous fungi and bacteria. Carboxylic acids can either be transported into the cells, to be used as nutrients, or extruded in response to acid stress conditions. The secondary active transporters Jen1 and Ady2 can mediate the uptake of the anionic form of these substrates by a H+-symport mechanism. The undissociated form of carboxylic acids is lipid-soluble, crossing the plasma membrane by simple diffusion. Furthermore, acetic acid can also be transported by facilitated diffusion via Fps1 channel. At the cytoplasmic physiological pH, the anionic form of the acid prevails and it can be exported by the Pdr12 pump. This review will highlight the mechanisms involving carboxylic acids transporters, and the way they operate according to the yeast cell response to environmental changes, as carbon source availability, extracellular pH and acid stress conditions.

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Acknowledgements

This work was supported by FCT I.P. through the strategic funding UID/BIA/04050/2013 and the project PTDC/BIA-MIC/5184/2014. D.R and G.T. acknowledge FCT for the SFRH/BD/96166/2013 and SFRH/BD/86221/2012, respectively.

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Authors and Affiliations

  1. CBMA-Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal

    Margarida Casal, Odília Queirós, Gabriel Talaia, David Ribas & Sandra Paiva

  2. CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116, Gandra, PRD, Portugal

    Odília Queirós

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  1. Margarida Casal
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  2. Odília Queirós
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  3. Gabriel Talaia
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  4. David Ribas
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  5. Sandra Paiva
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Correspondence to Margarida Casal .

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Editors and Affiliations

  1. Dept. of Microbiology, University of Córdoba, Córdoba, Spain

    José Ramos

  2. Department of Membrane Transport, Institute of Physiology, The Czech Academy of Sciences, Prague, Czech Republic

    Hana Sychrová

  3. Department of Mathematics and Technology, University of Applied Sciences, Koblenz, Remagen, Germany

    Maik Kschischo

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Casal, M., Queirós, O., Talaia, G., Ribas, D., Paiva, S. (2016). Carboxylic Acids Plasma Membrane Transporters in Saccharomyces cerevisiae . In: Ramos, J., Sychrová, H., Kschischo, M. (eds) Yeast Membrane Transport. Advances in Experimental Medicine and Biology, vol 892. Springer, Cham. https://doi.org/10.1007/978-3-319-25304-6_9

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