Abstract
The role of inflammation in prostate disease is still an open debate. Inflammation seems to play a role in the damage of prostatic tissue leading to molecular and histological changes with a remodeling of prostate tissue. These are probably the first steps toward neoplastic degeneration (Boehm K, Valdivieso R, Meskawi M, Larcher A, Schiffmann J, Sun M, Graefen M, Saad F, Parent ME, Karakiewicz PI (2015) Prostatitis, other genitourinary infections and prostate cancer: results from a population based case control study. World J Urol [Epub ahead of print]). Moreover, chronic inflammation and infections are related to the development of various human neoplasms, such as gastric carcinoma and Schistosoma haematobium-related bladder carcinoma. Inflammation and infection probably contribute to prostate carcinogenesis by causing cell and genome damage and thereby increasing cell proliferation (De Nunzio C et al (2011) The controversial relationship between benign prostatic hyperplasia and prostate cancer: the role of inflammation. Eur Urol 60(1):106–117). In summary, infectious prostatitis might have a causative role in the complex and multifactorial process of prostate degeneration and prostate carcinogenesis.
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Pisano, F. (2016). The Contribution of Prostate Infection and Inflammation to BPH and Cancer. In: Cai, T., Bjerklund Johansen, T. (eds) Prostatitis and Its Management. Springer, Cham. https://doi.org/10.1007/978-3-319-25175-2_10
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DOI: https://doi.org/10.1007/978-3-319-25175-2_10
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