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Monounsaturated Fatty Acid Mediated Liver-Adipose Tissue Crosstalk and Metabolic Regulation

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Hepatic De Novo Lipogenesis and Regulation of Metabolism

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Abstract

The maintenance of metabolic health requires complex regulation of metabolic processes in several tissues. The coordination of this metabolic regulation involves extensive crosstalk among tissues. Signaling factors that are secreted into the circulation and impart systemic metabolic effects include molecules such as hepatokines, adipokines and lipokines. Many of these factors regulate lipid metabolism, including de novo lipogenesis. Monounsaturated fatty acids, palmitoleate and oleate, are major products of de novo lipogenesis and exert significant control over metabolic regulation. These fatty acids may circulate as free or esterified forms and subsequently influence metabolic processes in tissues distinct from the ones in which they are synthesized. Examples include the effects of hepatic palmitoleate and oleate in adipose tissue and of adipose tissue-derived palmitoleate in liver. This chapter reviews secreted factors that regulate metabolic processes with a focus on lipids and fatty acids and communication between liver and adipose tissues mediated by these species.

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Acknowledgements

This work was supported by National Institutes of Health (NIH) Grant R01 DK062388, ADA 7-13-BS-118, and USDA Hatch W2005 (to J.M.N.) and NIH Predoctoral Training grant T32-DK-007665 (to M.S.B.).

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Authors and Affiliations

  1. Department of Medicine, University of Wisconsin-Madison, Madison, WI, 53706, USA

    Maggie S. Burhans

  2. Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA

    James M. Ntambi

  3. Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA

    James M. Ntambi

Authors
  1. Maggie S. Burhans
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  2. James M. Ntambi
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Correspondence to Maggie S. Burhans .

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Editors and Affiliations

  1. Departments of Biochemistry and Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA

    James M. Ntambi

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Burhans, M.S., Ntambi, J.M. (2016). Monounsaturated Fatty Acid Mediated Liver-Adipose Tissue Crosstalk and Metabolic Regulation. In: Ntambi, J. (eds) Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer, Cham. https://doi.org/10.1007/978-3-319-25065-6_12

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