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Spinal Cord Plasticity and Neuromodulation After SCI

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Emerging Therapies in Neurorehabilitation II

Part of the book series: Biosystems & Biorobotics ((BIOSYSROB,volume 10))

Abstract

Over the past several decades, it has been shown that the spinal cord exhibits significant adaptive plasticity during development and throughout life. This is normally a positive phenomenon, allowing the spinal cord to develop fundamental functions and learn novel behaviours. However, after a spinal cord injury, the pathways controlling the behaviours mediated by the spinal cord are interrupted and maladaptive plasticity can take place. The traditional approach to rehabilitation after spinal cord injury is to apply physical training exercises improving the overall condition and functioning of the patient, and thus to indirectly promote neural recovery. Emerging neuromodulation therapies that complement physical therapy have been proposed to directly stimulate and modify specific impaired neural pathways and thereby produce a more satisfactory functional state. This chapter presents an overview of these new treatment approaches.

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Acknowledgments

The authors would like to thank Dr. Jonathan R. Wolpaw, Dr. Elizabeth Winter Wolpaw and Dr. Natalie Mrachacz-Kersting for their invaluable help and important contribute in the writing of the chapter.

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  1. Cajal Institute, Spanish National Research Council, Madrid, Spain

    Stefano Piazza & Jaime Ibáñez

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  1. Stefano Piazza
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Correspondence to Stefano Piazza .

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    José L. Pons

  2. Bioengineering Group CSIC, Spanish Council for Scientific Research, Madrid, Spain

    Rafael Raya

  3. Neural Rehabilitation Group CSIC, Spanish Council for Scientific Research, Madrid, Spain

    José González

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Piazza, S., Ibáñez, J. (2016). Spinal Cord Plasticity and Neuromodulation After SCI. In: Pons, J., Raya, R., González, J. (eds) Emerging Therapies in Neurorehabilitation II. Biosystems & Biorobotics, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-319-24901-8_6

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