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Glaucoma and Other Optic Neuropathies

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Optical Coherence Tomography

Abstract

Optic neuropathies are characterized by specific patterns of damage to the ganglion cells and retinal nerve fiber layer. The reproducibility of spectral-domain optical coherence tomography (SD-OCT) has allowed for objective measurement and tracking of these patterns of damage. This chapter reviews major types of optic neuropathies including glaucoma, optic neuritis, disc edema, anterior ischemic optic neuropathy, disc drusen, diabetic papillitis, and Lyme papillitis.

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References

  1. Pasol J. Neuro-ophthalmic disease and optical coherence tomography: glaucoma look-alikes. Curr Opin Ophthalmol. 2011;22:124–32. doi:10.1097/ICU.0b013e328343c1a3.

    Article  PubMed  Google Scholar 

  2. Quigley HA. Neuronal death in glaucoma. Prog Retin Eye Res. 1999;18:39–57. doi:10.1016/S1350-9462(98)00014-7.

    Article  CAS  PubMed  Google Scholar 

  3. Sommer A, Katz J, Quigley HA, Miller NR, Robin AL, Richter RC, Witt KA. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol. 1991;109:77–83.

    Article  CAS  PubMed  Google Scholar 

  4. Lisboa R, Leite MT, Zangwill LM, Tafreshi A, Weinreb RN, Medeiros FA. Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography. Ophthalmology. 2012;119:2261–9. doi:10.1016/j.ophtha.2012.06.009.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Nakatani Y, Higashide T, Ohkubo S, Takeda H, Sugiyama K. Evaluation of macular thickness and peripapillary retinal nerve fiber layer thickness for detection of early glaucoma using spectral domain optical coherence tomography. J Glaucoma. 2011;20:252–9. doi:10.1097/IJG.0b013e3181e079ed.

    Article  PubMed  Google Scholar 

  6. Zeimer R, Asrani S, Zou S, Quigley H, Jampel H. Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping. A pilot study. Ophthalmology. 1998;105:224–31.

    Article  CAS  PubMed  Google Scholar 

  7. Hood DC, Raza AS, de Moraes CGV, Liebmann JM, Ritch R. Glaucomatous damage of the macula. Prog Retin Eye Res. 2013;32:1–21. doi:10.1016/j.preteyeres.2012.08.003.

    Article  PubMed  Google Scholar 

  8. Greenfield DS. Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography. Arch Ophthalmol. 2003;121:41. doi:10.1001/archopht.121.1.41.

    Article  PubMed  Google Scholar 

  9. Hood DC, Kardon RH. A framework for comparing structural and functional measures of glaucomatous damage. Prog Retin Eye Res. 2007;26:688–710. doi:10.1016/j.preteyeres.2007.08.001.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kanadani FN, Hood DC, Grippo TM, Wangsupadilok B, Harizman N, Greenstein VC, Liebmann JM, Ritch R. Structural and functional assessment of the macular region in patients with glaucoma. Br J Ophthalmol. 2006;90:1393–7. doi:10.1136/bjo.2006.099069.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Oberwahrenbrock T, Schippling S, Ringelstein M, Kaufhold F, Zimmermann H, Keser N, Young KL, Harmel J, Hartung H-P, Martin R, Paul F, Aktas O, Brandt AU. Retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography. Mult Scler Int. 2012;2012:1–10. doi:10.1155/2012/530305.

    Article  Google Scholar 

  12. Gordon-Lipkin E, Chodkowski B, Reich DS, Smith SA, Pulicken M, Balcer LJ, Frohman EM, Cutter G, Calabresi PA. Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology. 2007;69:1603–9. doi:10.1212/01.wnl.0000295995.46586.ae.

    Article  CAS  PubMed  Google Scholar 

  13. Gelfand JM, Goodin DS, Boscardin WJ, Nolan R, Cuneo A, Green AJ. Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypes. PLoS One. 2012;7, e36847. doi:10.1371/journal.pone.0036847.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Bichuetti DB, de Camargo AS, Falcão AB, Gonçalves FF, Tavares IM, de Oliveira EML. The retinal nerve fiber layer of patients with neuromyelitis optica and chronic relapsing optic neuritis is more severely damaged than patients with multiple sclerosis. J Neuroophthalmol. 2013;33:220–4. doi:10.1097/WNO.0b013e31829f39f1.

    Article  PubMed  Google Scholar 

  15. Sergott RC. Headaches associated with papilledema. Curr Pain Headache Rep. 2012;16:354–8. doi:10.1007/s11916-012-0283-x.

    Article  PubMed  Google Scholar 

  16. Johnson LN. Differentiating optic disc edema from optic nerve head drusen on optical coherence tomography. Arch Ophthalmol. 2009;127:45. doi:10.1001/archophthalmol.2008.524.

    Article  PubMed  Google Scholar 

  17. Johnson LN, Arnold AC. Incidence of nonarteritic and arteritic anterior ischemic optic neuropathy. Population-based study in the state of Missouri and Los Angeles County, California. J Neuroophthalmol Off J North Am Neuro Ophthalmol Soc. 1994;14:38–44.

    CAS  Google Scholar 

  18. Hayreh SS, Zimmerman MB. Nonarteritic anterior ischemic optic neuropathy. Ophthalmology. 2008;115:298–305.e2. doi:10.1016/j.ophtha.2007.05.027.

    Article  PubMed  Google Scholar 

  19. Dotan G, Goldstein M, Kesler A, Skarf B. Long-term retinal nerve fiber layer changes following nonarteritic anterior ischemic optic neuropathy. Clin Ophthalmol. 2013;7:735–40. doi:10.2147/OPTH.S42522.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Levin LA. Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. Arch Ophthalmol. 1996;114:488. doi:10.1001/archopht.1996.01100130484027.

    Article  CAS  PubMed  Google Scholar 

  21. Hayreh S. Management of ischemic optic neuropathies. Indian J Ophthalmol. 2011;59:123. doi:10.4103/0301-4738.77024.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Arnold AC. Pathogenesis of nonarteritic anterior ischemic optic neuropathy. J Neuroophthalmol Off J North Am Neuroophthalmol Soc. 2003;23:157–63.

    Article  Google Scholar 

  23. Jacobson DM. Nonarteritic anterior ischemic optic neuropathy: a case-control study of potential risk factors. Arch Ophthalmol. 1997;115:1403. doi:10.1001/archopht.1997.01100160573008.

    Article  CAS  PubMed  Google Scholar 

  24. Mojon DS. Association between sleep apnea syndrome and nonarteritic anterior ischemic optic neuropathy. Arch Ophthalmol. 2002;120:601. doi:10.1001/archopht.120.5.601.

    Article  PubMed  Google Scholar 

  25. Pomeranz HD, Bhavsar AR. Nonarteritic ischemic optic neuropathy developing soon after use of sildenafil (viagra): a report of seven new cases. J Neuroophthalmol Off J North Am Neuroophthalmol Soc. 2005;25:9–13.

    Article  Google Scholar 

  26. Bellusci C, Savini G, Carbonelli M, Carelli V, Sadun AA, Barboni P. Retinal nerve fiber layer thickness in nonarteritic anterior ischemic optic neuropathy: OCT characterization of the acute and resolving phases. Graefes Arch Clin Exp Ophthalmol. 2008;246:641–7. doi:10.1007/s00417-008-0767-x.

    Article  PubMed  Google Scholar 

  27. Aggarwal D, Tan O, Huang D, Sadun AA. Patterns of ganglion cell complex and nerve fiber layer loss in nonarteritic ischemic optic neuropathy by fourier-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53:4539–45. doi:10.1167/iovs.11-9300.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Danesh-Meyer HV, Boland MV, Savino PJ, Miller NR, Subramanian PS, Girkin CA, Quigley HA. Optic disc morphology in open-angle glaucoma compared with anterior ischemic optic neuropathies. Invest Ophthalmol Vis Sci. 2010;51:2003–10. doi:10.1167/iovs.09-3492.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Auw-Haedrich C, Staubach F, Witschel H. Optic disk drusen. Surv Ophthalmol. 2002;47:515–32. doi:10.1016/S0039-6257(02)00357-0.

    Article  PubMed  Google Scholar 

  30. Tso MO. Pathology and pathogenesis of drusen of the optic nervehead. Ophthalmology. 1981;88:1066–80.

    Article  CAS  PubMed  Google Scholar 

  31. Choi SS, Zawadzki RJ, Greiner MA, Werner JS, Keltner JL. Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen. J Neuroophthalmol. 2008;28:120–5. doi:10.1097/WNO.0b013e318175c6f5.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Lee KM, Woo SJ, Hwang J-M. Differentiation of optic nerve head drusen and optic disc edema with spectral-domain optical coherence tomography. Ophthalmology. 2011;118:971–7. doi:10.1016/j.ophtha.2010.09.006.

    Article  PubMed  Google Scholar 

  33. Regillo CD. Diabetic papillopathy: patient characteristics and fundus findings. Arch Ophthalmol. 1995;113:889. doi:10.1001/archopht.1995.01100070063026.

    Article  CAS  PubMed  Google Scholar 

  34. Nakamura M. Serous macular detachment due to diabetic papillopathy detected using optical coherence tomography. Arch Ophthalmol. 2009;127:105. doi:10.1001/archophthalmol.2008.533.

    Article  PubMed  Google Scholar 

  35. Träisk F, Lindquist L. Optic nerve involvement in Lyme disease. Curr Opin Ophthalmol. 2012;23:485–90. doi:10.1097/ICU.0b013e328358b1eb.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neuro-Ophthalmology, Wills Eye Hospital, Philadelphia, PA, USA

    Teri T. Kleinberg MD, MSc

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  1. Teri T. Kleinberg MD, MSc
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Correspondence to Teri T. Kleinberg MD, MSc .

Editor information

Editors and Affiliations

  1. London, United Kingdom

    Aniz Girach

  2. Neuro-Ophthalmology Service, Wills Eye Institute, Philadelphia, Pennsylvania, USA

    Robert C. Sergott

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© 2016 Springer International Publishing Switzerland

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Cite this chapter

Kleinberg, T.T. (2016). Glaucoma and Other Optic Neuropathies. In: Girach, A., Sergott, R. (eds) Optical Coherence Tomography. Springer, Cham. https://doi.org/10.1007/978-3-319-24817-2_8

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  • DOI: https://doi.org/10.1007/978-3-319-24817-2_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-24815-8

  • Online ISBN: 978-3-319-24817-2

  • eBook Packages: MedicineMedicine (R0)

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