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Supportive Cancer Care pp 139–162Cite as

Delayed Nausea/Emesis

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Abstract

The symptoms of chemotherapy-induced nausea and vomiting cause significant physical and emotional distress. Some of the most troubling effects result from delayed symptoms, which occur greater than 24 hours following chemotherapy. Severe or prolonged nausea or vomiting can interfere with a patient’s ability to receive proper treatment and even cause patients to postpone or refuse potentially curative therapy. Providing adequate prophylaxis can prevent these symptoms, allowing chemotherapy to be better tolerated and given without dose modification. The antiemetic regimen which has shown the most promise in clinical trials is a 5-hydroxytryptamine (5-HT3) receptor antagonist combined with a neurokinin-1 receptor antagonist and dexamethasone. This chapter reviews the pathophysiology, diagnosis, and management of chemotherapy-induced nausea and vomiting, with special focus on delayed symptoms and the use of current clinical practice guidelines.

Keywords

  • National Comprehensive Cancer Network
  • National Comprehensive Cancer Network
  • Emetogenic Chemotherapy
  • Highly Emetogenic Chemotherapy
  • Moderately Emetogenic Chemotherapy

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Authors and Affiliations

  1. Moores Cancer Center Gynecology, 3855 Health Sciences Dr, La Jolla, CA, 92093, USA

    Lisa M. Bean & Steve Plaxe

  2. Division of Gynecologic Oncology, Department of Reproductive Medicine, University of California, San Diego, UCSD Medical Center, San Diego, CA, USA

    Lisa M. Bean & Steve Plaxe

  3. Rebecca and John Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA, 92093-0987, USA

    Lisa M. Bean & Steve Plaxe

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  1. University of Arizona Cancer Center, Tucson, AZ, USA

    David Alberts, Maria Lluria-Prevatt & Karen Weihs,  & 

  2. University of Arizona Arizona Cancer Center, Tucson, AZ, USA

    Stephanie Kha

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Bean, L.M., Plaxe, S. (2016). Delayed Nausea/Emesis. In: Alberts, D., Lluria-Prevatt, M., Kha, S., Weihs, K. (eds) Supportive Cancer Care. Springer, Cham. https://doi.org/10.1007/978-3-319-24814-1_9

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