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Renal H+-ATPase Function, Regulation, and Role in Distal Renal Tubular Acidosis

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Regulation of Ca2+-ATPases,V-ATPases and F-ATPases

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 14))

Abstract

The kidney plays an important role in systemic acid–base balance by maintaining the blood HCO3 − concentration within narrow limits. Various H+/base transport processes and metabolic pathways have evolved that orchestrate in a coordinated fashion, the absorption of the filtered bicarbonate load and the generation of new HCO3 −. The impairment of either of these processes in the nephron can result in a decrease in the blood HCO3 − concentration with concomitant metabolic acidosis. In the renal proximal tubule and the collecting duct, secretion of protons by the vacuolar H+-ATPase is one of the key transport steps involved in both the reclamation of filtered HCO3 − and the generation of new HCO3 −. The activity of the vacuolar H+-ATPase is dynamically regulated by various local and systemic factors. Naturally occurring mutations in specific subunits of the vacuolar H+-ATPase cause the disease distal renal tubular acidosis.

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Acknowledgment

The preparation of this article was supported in part by funds from the NIH (R01-DK077162), the Allan Smidt Charitable Fund, the Factor Family Foundation, and the Arvey Foundation.

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Authors and Affiliations

  1. Division of Nephrology, David Geffen School of Medicine, UCLA, 7-155 Factor Bldg, 10833 Le Conte Avenue, Los Angeles, CA, 90035, USA

    Ira Kurtz, Irina Rogova, Vladimir Turygin, Jingbo Huang, Natalia Abuladze & Alexander Pushkin

  2. Brain Research Institute, UCLA, Los Angeles, CA, USA

    Ira Kurtz

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  1. Ira Kurtz
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  2. Irina Rogova
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  3. Vladimir Turygin
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  4. Jingbo Huang
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  5. Natalia Abuladze
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  6. Alexander Pushkin
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Correspondence to Ira Kurtz .

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  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Kurtz, I., Rogova, I., Turygin, V., Huang, J., Abuladze, N., Pushkin, A. (2016). Renal H+-ATPase Function, Regulation, and Role in Distal Renal Tubular Acidosis. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Advances in Biochemistry in Health and Disease, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-24780-9_25

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