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Role of ATPases in Disease Processes

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Regulation of Ca2+-ATPases,V-ATPases and F-ATPases

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 14))

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Abstract

In the course of evolution, a number of agents have emerged as carriers of signals that are essential for the correct functioning of cell life. Ca2+ is the most versatile of all of them; other messengers are normally committed to the regulation of a single cell function, or at most a few of them. Ca2+ instead regulates a plethora of cellular processes, beginning with the origin of new cell life, its growth, proliferation and differentiation and ending with its termination in the process of programmed cell death. Thus, precise regulation of calcium within the cellular compartments is of utmost importance to maintain proper cellular function. Calcium balance is finely regulated within the cell by the coordinated action of the calcium pumps and the channels. As calcium ions play such critical role in regulation of varied cellular functions, malfunction of the calcium pumps is associated with different disease progression. In the present review, we have discussed the properties and functioning of the calcium pumps and also highlighted its association with different malfunction and diseases. This knowledge might be effective in using the calcium pumps as therapeutic targets for drug development in the near future.

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Acknowledgements

The authors sincerely acknowledge Department of Atomic Energy for financial assistance and Bose Institute for providing facilities.

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Authors and Affiliations

  1. Division of Molecular Medicine, Bose Institute, P-1/12, Calcutta Improvement Trust Scheme VII M, Kolkata, 700 054, India

    Swatilekha Ghosh & Parimal C. Sen

Authors
  1. Swatilekha Ghosh
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  2. Parimal C. Sen
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Correspondence to Parimal C. Sen .

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Editors and Affiliations

  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Ghosh, S., Sen, P.C. (2016). Role of ATPases in Disease Processes. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Advances in Biochemistry in Health and Disease, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-24780-9_24

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