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F1F0-ATPase Functions Under Markedly Acidic Conditions in Bacteria

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Regulation of Ca2+-ATPases,V-ATPases and F-ATPases

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 14))

Abstract

ATP synthase (F1F0-ATPase), consisting of a water-soluble F1 portion and a transmembrane FO portion, is present in bacterial cytoplasmic membranes and the inner membranes of mitochondria and chloroplasts. This enzyme plays a central role in biological energy transduction. F1F0-ATPase is bifunctional, being involved in ATP synthesis and hydrolysis. When bacteria are subjected to specific environmental challenges, F1F0-ATPase changes its operation to overcome the challenges. F1F0-ATPase synthesizes ATP using energy released from proton movement in oxidative phosphorylation under aerobic conditions at a near-neutral pH. This enzyme exports protons coupled with ATP hydrolysis as a reverse reaction in some specific environments. Recent research has indicated that F1F0-ATPase plays an important role in bacterial survival in markedly acidic environments. In this chapter, the roles of F1F0-ATPase in bacteria subjected to marked acidic stress are discussed.

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Acknowledgements

The author would like to express thanks to Hiroshi Kobayashi (Chiba University) for his valuable suggestions.

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Authors and Affiliations

  1. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences Guangzhou, 190 Kaiyuan Road, Science Park, Guangzhou, 510530, P. R. China

    Yirong Sun

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  1. Yirong Sun
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Correspondence to Yirong Sun .

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Editors and Affiliations

  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Sun, Y. (2016). F1F0-ATPase Functions Under Markedly Acidic Conditions in Bacteria. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Advances in Biochemistry in Health and Disease, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-24780-9_22

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