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Regulation of Ca2+ Transport ATPases by Amino- and Carboxy-Terminal Extensions: Mechanisms and (Patho)Physiological Implications

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Regulation of Ca2+-ATPases,V-ATPases and F-ATPases

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 14))

Abstract

Ca2+ transport ATPases play a vital role in maintaining low cytosolic Ca2+ concentrations. Three types of Ca2+ ATPases exist: the Sarco/Endoplasmic Reticulum Ca2+ ATPases (SERCA), Secretory Pathway Ca2+ ATPases (SPCA), and Plasma Membrane Ca2+ ATPases (PMCA). The expression of numerous Ca2+ ATPase isoforms and splice variants generate a complex toolkit of Ca2+ transporters that provide cell type and compartmental specific functions. Still, the basic Ca2+ transporting mechanism is highly conserved in all Ca2+ ATPase variants, which is related to a highly conserved core structure holding a transmembrane domain for Ca2+ binding and transport, and three cytosolic domains, which coordinate ATP hydrolysis. In contrast, the N- and C-terminal stretches of the various isoforms and splice variants display much more variation. They provide additional isoform or splice variant specific functions to the Ca2+ pumps, which are reviewed here. The N- and C-termini may regulate the enzymatic properties of the Ca2+ pumps via intramolecular interactions, contain targeting signals, recruit other proteins, bind lipids/ions or may be subjected to posttranslational modifications. Insights into the properties and molecular mechanisms of the N- and C-terminal extensions may offer novel therapeutic opportunities to regulate and control specific Ca2+ transporter isoforms in a diseased context.

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Acknowledgements

This work has been funded by the Flanders Research Foundation FWO G.0442.12 and G.0B11.15, the Inter-University Attraction Poles program (P7/13), and the KU Leuven (OT/13/091).

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  1. Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg ON1, Herestraat 49/box 802, 3000, Leuven, Belgium

    Jialin Chen, Susanne Smaardijk, Ilse Vandecaetsbeek & Peter Vangheluwe

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  1. Jialin Chen
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  2. Susanne Smaardijk
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  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Chen, J., Smaardijk, S., Vandecaetsbeek, I., Vangheluwe, P. (2016). Regulation of Ca2+ Transport ATPases by Amino- and Carboxy-Terminal Extensions: Mechanisms and (Patho)Physiological Implications. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Advances in Biochemistry in Health and Disease, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-24780-9_14

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