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Regulation of Cardiac Sarco(endo)plasmic Reticulum Calcium-ATPases (SERCA2a) in Response to Exercise

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Regulation of Ca2+-ATPases,V-ATPases and F-ATPases

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 14))

Abstract

Sarco(endo)plasmic reticulum calcium ATPase (SERCA2a) plays an integral role in Ca2+ cycling in the heart. After a myocardial contraction has occurred, SERCA2a is primarily responsible for transporting Ca2+ out of the cytosol into the sarcoplasmic reticulum. Consequently, SERCA2a is key in determining relaxation time and inotropy of subsequent contractions. There are ten different SERCA isoforms in the body, where SERCA2a is the isoform expressed in the heart. Both SERCA2a expression and activity are reduced in models of disease. As such, a large body of research has examined SERCA2a and how it might be used as a means to restore heart function in models of disease. In this chapter, we examine various regulatory mechanisms of SERCA2a and how these mechanisms affect SERCA2a and cardiac function. Transcriptional, protein (e.g., phospholamban and sarcolipin), hormonal (e.g., thyroid hormone and adiponectin), and posttranslational modification (e.g., nitration, glutathionylation, SUMOylation, acetylation, glycosylation, and O-glcNAcylation) processes as they regulate SERCA2a are discussed. Additionally, exercise and its effect on the regulatory mechanisms of SERCA2a is examined.

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Authors and Affiliations

  1. Health, Leisure & Human Performance Research Institute, Faculty of Kinesiology & Recreation Management, University of Manitoba, Winnipeg, MB, Canada, R3T 2N2

    Naomi C. Hamm, Andrew N. Stammers, Michael W. Hlynsky, Dustin E. Kimber, D. Scott Kehler & Todd A. Duhamel

  2. Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada, R3T 2N2

    Naomi C. Hamm, Andrew N. Stammers, Shanel E. Susser, Michael W. Hlynsky, Dustin E. Kimber, D. Scott Kehler & Todd A. Duhamel

  3. Department of Physiology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada, R3T 2N2

    Shanel E. Susser & Todd A. Duhamel

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  1. Naomi C. Hamm
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  2. Andrew N. Stammers
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  3. Shanel E. Susser
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  4. Michael W. Hlynsky
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  5. Dustin E. Kimber
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  6. D. Scott Kehler
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  7. Todd A. Duhamel
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Correspondence to Todd A. Duhamel .

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Editors and Affiliations

  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Hamm, N.C. et al. (2016). Regulation of Cardiac Sarco(endo)plasmic Reticulum Calcium-ATPases (SERCA2a) in Response to Exercise. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Advances in Biochemistry in Health and Disease, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-24780-9_11

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