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Xenobiotics-Mediated Modulation of ATPases and Biomedical Implications

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Book cover Regulation of Membrane Na+-K+ ATPase

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 15))

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Abstract

A xenobiotic is a chemical compound found in an organism but normally not produced or expected to be present in it. Xenobiotics are the substances foreign to any biological system. Mostly, these are artificial or synthetic substances such as drugs including antibiotics, which did not exist in nature. Natural compounds can also become xenobiotics if they are taken up by another organism. Pollutants such as dioxins, polychlorinated biphenyls, pesticides, and dyes also belong to this category. A compound that is normal to one organism may be a xenobiotic to another; for example the sewage for a fish. When an animal produces a toxin as a defense mechanism against predators, these toxins can be thought of as xenobiotics to the predator. However, predators can also evolve defenses against these xenobiotics. The term xenobiotic is also used to refer to organs transplanted from one species to another. Most of the xenobiotics evoke response in an individual by acting at their specific targets. Some of them actively interact with different ATPases and are capable to efficiently modulate their structures and functions. This chapter illustrates an updated account of interactions of different xenobiotics with varied ATPases, xenobiotics induced modulations in the structures and functions of different ATPases and their implications in design and development of newer potential anticancer agents. In addition, the possible ameliorative strategies to encounter adverse effects generated by such xenobiotics are also discussed.

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Acknowledgements

SS is grateful to UGC-New Delhi for the financial support in the form of an award of Dr. D.S. Kothari Postdoctoral Research Fellowship. SKJ thanks UGC-New Delhi for financial support in the form of a research fellowship. NJS is grateful to the Research Center, Center for Scientific and Medical Female Colleges, King Saud University, Riyadh, Saudi Arabia, for the financial support.

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Authors and Affiliations

  1. Departments of Biochemistry, Faculty of Science, University of Allahabad, Allahabad, 211002, UP, India

    Bechan Sharma, Shweta Singh & Sunil Kumar Jaiswal

  2. Department of Biochemistry, College of Science, King Saud University, Riyadh, 11495, Saudi Arabia

    Nikhat Jamal Siddiqi

Authors
  1. Bechan Sharma
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  2. Shweta Singh
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  3. Sunil Kumar Jaiswal
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  4. Nikhat Jamal Siddiqi
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Corresponding author

Correspondence to Bechan Sharma .

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Editors and Affiliations

  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Sharma, B., Singh, S., Jaiswal, S.K., Siddiqi, N.J. (2016). Xenobiotics-Mediated Modulation of ATPases and Biomedical Implications. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Membrane Na+-K+ ATPase. Advances in Biochemistry in Health and Disease, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-24750-2_10

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