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Role of Posttranslational Modifications in Replication Initiation

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The Initiation of DNA Replication in Eukaryotes

Abstract

DNA replication must occur precisely once per cell cycle to maintain a stable genome. An important means to achieve this is through multilayered regulation of replication initiation at both local and global levels. Recent genetic and biochemical studies in several organisms have revealed critical roles of posttranslational modifications (PTMs) in these regulations. While the best-demonstrated class of PTMs is kinase-mediated phosphorylation, additional forms of PTMs including ubiquitylation, methylation, and acetylation also contribute to the control of replication initiation. Here we survey the current understanding of how different types of modifications govern and fine-tune several aspects of replication initiation, including origin licensing, firing, and global replication timing.

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  1. Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA

    Lei Wei & Xiaolan Zhao

  2. Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA

    Lei Wei & Xiaolan Zhao

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    Daniel L. Kaplan

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Wei, L., Zhao, X. (2016). Role of Posttranslational Modifications in Replication Initiation. In: Kaplan, D. (eds) The Initiation of DNA Replication in Eukaryotes. Springer, Cham. https://doi.org/10.1007/978-3-319-24696-3_18

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