Abstract
Brucellosis has been an important zoonotic disease globally. Since Brucella can infect and survive without inducing a massive inflammatory response, this bacteria was labeled as “stealth pathogen.” Its protean and diverse clinical presentation can mimic other infectious and noninfectious diseases, posing challenges to physicians in reaching a diagnosis, and merited the label “disease of mistakes.” The complications of brucellosis are common and can involve a wide range of body organs and localization, neurobrucellosis being among the most serious ones. Awareness about the disease and the use of appropriate Brucella-specific tests can expedite the accurate diagnosis.
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Abbreviations
- BCV:
-
Brucella-containing vacuoles
- CSF:
-
Cerebrospinal fluid
References
Al Dahouk S, Sprague LD, Neubauer H (2013) New developments in the diagnostic procedures for zoonotic brucellosis in humans. Rev Sci Tech 32:177–188
Araj GF (1997) Enzyme linked immunosorbent assay, not agglutination test is the test of choice for the diagnosis of neurobrucellosis (letter). Clin Infect Dis 25:942
Araj GF (2010) Update on laboratory diagnosis of human brucellosis. Int J Antimicrob Agents 36(suppl 1):S12–S17
Araj GF, Lulu AR, Khateeb MI, Saadah MA, Shakir RA (1988) ELISA versus routine tests in the diagnosis of patients with systemic and neurobrucellosis. Acta Pathol Microbiol Scand 96:171–176
Araj GF, Lulu AR, Mustafa MY, Khateeb MI (1986) Evaluation of ELISA in the diagnosis of acute and chronic brucellosis in human beings. J Hyg (London) 97:457–469
Araj GF, Lulu AR, Saadah MA, Mousa AM, Strannegard I-L, Shakir RA (1986) Rapid diagnosis of central nervous system brucellosis by ELISA. J Neuroimmunol 12:173–182
Ariza J, Corredoira J, Pallares R, Vilarich PF, Rufi G, Pujol M, Gudiol F (1995) Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis 20:1241–1249
Aygen B, Doĝanay M, Sümerkan B, Yildiz O, Kayabaş U (2002) Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Mal Infect 32:485–493
Baldi PC, Giambartolomei GH (2013) Immunopathology of Brucella infection. Recent Pat Antiinfect Drug Discov 8:18–26
Barroso Garcia P, Rodriguez-Contreras Pelayo R, Gil Extremera B, Maldonado Martin A, GuilarroHeratas G, Martin Salguero A, Baron Carreno T (2002) Study of 1595 brucellosis cases in the Almeria province (1972–1998) based on epidemiological data from disease reporting. Rev Clin Esp 202:577–582
Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, Akdeniz H (2010) Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis 14:e469–e478
Colmenero JD, Reguera JM, Martos F, Sanchez-De-Mora D, Delgado M, Causse M, Martin-Farafan A, Juarez C (1996) Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 75:195–211
Corbel MJ (1997) Brucellosis: an overview. Emerg Infect Dis 3:213–221
Dalrymple-Champneys W (1960) Clinical features, Brucella infection and undulant fever in man. Oxford University Press, London
Dean A, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J (2012) Clinical manifestations of human brucellosis: a systematic review and meta-analysis. PLoS Negl Trop Dis 6, e1929. doi:10.1371/journal.pntd.0001929
Dean A, Crump L, Greter H, Schelling E, Zinsstag J (2012) Global burden of human brucellosis: a systematic review of disease frequency. PLoS Negl Trop Dis 6, e1865. doi:10.1371/journal.pntd.0001865
Doganay G, Doganay M (2013) Brucella as a potential agent of bioterrorism. Recent Pat Antiinfect Drug Discov 8:27–33
Erdem H, Ulu-Kilic A, Kilic S, Karahocagil M, Shehata G, Eren-Tulek N, Yetkin F, Celen MK, Ceran N, Gul H, Mert G, Tekin-Koruk S, Dizbay M, Inal A, Nayman-Alpat S, Bosilkovski M, Inan D, Saltoglu N, Abdel-Baky L, Adeva-Bartolome MT, Ceylan B, Sacar S, Turhan V, Yılmaz E, Elaldi N, Kocak-Tufan Z, Uğurlu K, Dokuzoğuz B, Yılmaz H, Gundes S, Guner R, Ozgunes N, Ulcay A, Unal S, Dayan S, Gorenek L, Karakas A, Tasova Y, Usluer G, Bayindir Y, Kurtaran B, Sipahi O, Leblebicioglu H (2011) Efficacy and tolerability of antibiotic combinations in neurobrucellosis: results of the Istanbul Study. Antimicrob Agents Chemother 56:1523–1528
Franco MP, Mulder M, Gilman RH, Smits HL (2007) Human brucellosis. Lancet Infect Dis 7:775–786
Godfroid J, AlDahouk S, Pappas G, Roth F, Matope G, Mama J, Marcotty T, Pfeiffer D, Skjerve E (2013) A “One Health” surveillance and control of brucellosis in developing countries: moving away from improvisation. Comp Immunol Microbiol Infect Dis 36:241–248
Godfroid J, Cloeckaert A, Liautard JP, Kohler S, Fretin D, Walravens K, Garin-Bastuji B, Letesson JJ (2005) From the discovery of the Malta fever’s agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis. Vet Res 36:313–326
Gorvel J-P (2014) “If you bring an alarm, we will destroy it”, said Brucella to the host cell. Virulence 5:460–462
Gul HC, Erdem H, Bek S (2009) Overview of neurobrucellosis: a pooled analysis of 187 cases. Int J Infect Dis 13:e339–e343
Guven T, Ugurlu K, Ergonul O, Celikbas AK, Gok SE, Comoglu S, Baykam N, Dokuzoguz B (2013) Neurobrucellosis: clinical and diagnostic features. Clin Infect Dis 56:1407–1412
HasanjaniRoushan MR, Mohrez M, SmailnejadGangi SM, SolemaniAmiri MJ, Hajiahmadi M (2004) Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, Northern Iran. Epidemiol Infect 132:1109–1114
Lulu AR, Araj GF, Khateeb MI, Mustafa MY, Yusuf AR, Fenech FF (1988) Human brucellosis in Kuwait: a prospective study of 400 cases. Q J Med 66:39–54
Madkour MM (1989) Brucellosis. Butterworths, London
Mantur BG, Amarnath SK, Shinde RS (2007) Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 25:188–202
Martirosyan A, Moreno E, Gorvel JP (2011) An evolutionary strategy for a stealthy intracellular Brucella pathogen. Immunol Rev 240:211–234
Memish Z, Mah MW, Al Mahmoud S, Al Shaalan M, Khan MY (2000) Brucella bacteraemia: clinical and laboratory observations in 160 patients. J Infect 40:59–63
Olsen SC, Palmer MV (2014) Advancement of knowledge of Brucella over the past 50 years. Vet Pathol 51:1076–1089
Pappas G, Akritidis N, Bosilkovski M, Tsianos E (2005) Brucellosis. N Engl J Med 352:2325–2336
Perkins SB, Smither SJ, Atkins HS (2010) Towards a Brucella vaccine for humans. FEMS Microbiol Rev 34:379–394
Rubach MP, Halliday JE, Cleaveland S, Crump JA (2013) Brucellosis in low-income and middle-income countries. Curr Opin Infect Dis 26:404–412
Shakir RA, Al-Din ASN, Araj GF, Lulu AR, Mousa AR, Saadah MA (1987) Clinical categories of neurobrucellosis: a report on 19 cases. Brain 110:213–223
Solera J, Martinez-Alfaro E, Espinosa A, Castillejos ML, Geijo P, Rodriguez-Zapata M (1998) Multivariate model for predicting relapse in human brucellosis. J Infect 36:85–92
Spink WW (1956) The nature of brucellosis. University of Minnesota Press, Minneapolis
Traxler RM, Guerra MA, Morrow MG, Haupt T, Morrison J, Saah JR, Smith CG, Williams C, Fleischuauer AT, Lee PA, Stanek D, Trevino-Garrison I, Franklin P, Oakes P, Hand S, Shadomy SV, Blaney DD, Lehman MW, Benoit TJ, Stoddard RA, Tiller RV, De BK, Bower W, Smith TL (2013) Review of brucellosis cases from laboratory exposures in the United States in 2008 to 2011 and improved strategies for disease prevention. J Clin Microbiol 51:3132–3136
Young EJ (2010) Brucella species. In: Mandell GL, Bennet JE, Dolin R (eds) Principles and practice of infectious diseases. Churchill Livingstone, Philadelphia, pp 2921–2925
Young EJ (1983) Human brucellosis. Rev Infect Dis 5:821–842
Young EJ (1995) An overview of human brucellosis. Clin Infect Dis 21:283–290
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Araj, G.F. (2016). Human Brucellosis and Its Complications. In: Turgut, M., Haddad, F., de Divitiis, O. (eds) Neurobrucellosis. Springer, Cham. https://doi.org/10.1007/978-3-319-24639-0_2
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