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Reviews in Fluorescence 2015 pp 147–169Cite as

Indicators for Ionic Copper in Biology

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Part of the book series: Reviews in Fluorescence ((RFLU,volume 8))

Abstract

Despite its status as a trace element in many organisms, copper is garnering increased interest for its biological functions and potential roles in many diseases. This review summarizes recent progress in the use of fluorescent indicators for determining copper ions in a variety of biological matrices. Following a brief summary of the chemistry and biology of Cu(I) and Cu(II), the review covers both organic fluorescent indicators as well as biologically derived fluorescent indicators or sensors. The future outlook for improved indicators and sensors is discussed.

We very much regret that it was not possible to discuss all the important developments in fluorescence-based copper sensors within this limited space, so we focused upon those that seemed of greatest interest to us. We ask forgiveness from the many creative investigators whose work could not be included.

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Acknowledgments

We would like to thank all of our co-workers who did the work described herein, as well as the National Institutes of Health, National Science Foundation, Office of Naval Research, and National Oceanic and Atmospheric Administration for support.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, MD, 21201, USA

    Richard B. Thompson & Hui Hui Zeng

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  1. Richard B. Thompson
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Correspondence to Richard B. Thompson .

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Editors and Affiliations

  1. Institute of Fluorescence, University of Maryland Baltimore County Institute of Fluorescence, BALTIMORE, Maryland, USA

    Chris D. Geddes

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Thompson, R.B., Zeng, H.H. (2016). Indicators for Ionic Copper in Biology. In: Geddes, C. (eds) Reviews in Fluorescence 2015. Reviews in Fluorescence, vol 8. Springer, Cham. https://doi.org/10.1007/978-3-319-24609-3_6

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