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Model of Drugs Penetration Through Biological Membrane

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Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 362))

Abstract

This work deals with pharmacokinetics modeling and compilation of functional models. There are three mathematical models representing actions beginning intravascular drug administration until the elimination from the body. Graphics dependences are outputs of these models, provide a quick idea about behavior of drugs in the body and time period, when is medicine completely eliminated. The main model illustrates the penetration of drug across biological membrane using the same principles, but the model tells of what happens to take place on bio membranes and its surrounding area.

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References

  1. Ladokhin, A.S.: Measuring membrane penetration with depth-dependent fluorescence quenching: Distribution analysis is coming of age. Biochimica Et Biophysica Acta-Biomembranes 1838, 2289–2295 (2014)

    Article  Google Scholar 

  2. Bolzinger, M.A., Briancon, S., Pelletier, J., Chevalier, Y.: Penetration of drugs through skin, a complex rate-controlling membrane. Curr. Opin. Colloid Interface Sci. 17, 156–165 (2012)

    Article  Google Scholar 

  3. Christ, A., Szurkowski, J., Hanh, B.D., Wartewig, S., Kopycinska, M., Neubert, R.H.H., Cobet, U.: Drug penetration into a membrane investigated by photoacoustic and FTIR-ATR spectroscopy. Anal. Sci. 17, S371–S373 (2001)

    Google Scholar 

  4. Cídlová, H., Štěpán, J.: Řešené příklady z fyzikální chemie. Masarykova univerzita, Brno (2008)

    Google Scholar 

  5. Zathurecký, L.: Biofarmácia a farmakokinetika. Vydavateľstvo Osveta, Martin (1989)

    Google Scholar 

  6. Cerny, M., Penhaker, M.: The HomeCare and circadian rhythm. 2008 International Special Topic Conference on Information Technology and Applications in Biomedicine, vols. 1 and 2, pp. 110–113 (2008)

    Google Scholar 

  7. Cerny, M., Pokorny, M.: Circadian rhythm evaluation using fuzzy logic. Stud. Comput. Intell. 457, 289–298 (2013)

    Google Scholar 

  8. Eck, V., Razím, M.: Biokybernetika. ČVUT, Elektrotechnická fakulta, Praha (1996)

    Google Scholar 

  9. Penhaker, M., Tiefenbach, P., Kobza, F.: Lékařská kybernetika. VŠB - Technická univerzita Ostrava, Ostrava (2007)

    Google Scholar 

  10. Cerny, M., Penhaker, M.: Wireless body sensor network in health maintenance systems. Elektronika Ir Elektrotechnika 113–116 (2011)

    Google Scholar 

  11. Penhaker, M., Darebnikova, M., Jurek, F., Augustynek, M.: Evaluation of electrocardiographic leads and establishing significance intra-individuality. In: Innovations in Bio-inspired Computing and Applications, pp. 295–303. Springer International Publishing (2014)

    Google Scholar 

  12. Augustynek, M., Penhaker, M., Korpas, D., Society, I.C.: Controlling peacemakers by accelerometers. 2010 Second International Conference on Computer Engineering and Applications: Iccea 2010, Proceedings, vol. 2, pp. 161–163 (2010)

    Google Scholar 

  13. Komers, K., Čegan, A., Komersová, A.: Základy farmakokinetiky. Univerzita Pardubice, Pardubice (2011)

    Google Scholar 

  14. Wijk van Brievingh, R.P.V., Möller, D.: Biomedical modeling and simulation on a PC: a workbench for physiology and biomedical engineering. Springer, New York (1993)

    Google Scholar 

  15. Potůček, J.: Metodologie modelování biologických systémů. České vysoké učení technické, V Praze (2009)

    Google Scholar 

  16. Augustynek, M., Penhaker, M.: Finger Plethysmography classification by orthogonal transformations. In: Computer Engineering and Applications (ICCEA), 2010 Second International Conference on, pp. 173–177. IEEE

    Google Scholar 

  17. Augustynek, M., Penhaker, M., Semkovic, J., Penhakerova, P., Cerny, M.: Measurement and diagnosis assessment of plethysmographycal record. In: 5th Kuala Lumpur International Conference on Biomedical Engineering (BIOMED 2011), pp. 320–323

    Google Scholar 

  18. Zemanova, A.: Model of drugs penetration through biological membrane (2013)

    Google Scholar 

  19. Penhaker, M., Cerny, M., Rosulek, M.: Sensitivity analysis and application of transducers. 2008 5th International Summer School and Symposium on Medical Devices and Biosensors, pp. 85–88 (2008)

    Google Scholar 

  20. Augustynek, M., Penhaker, M., Cerny, M., Cernohorsky, J., Bryjova, I.: Education of biomedical engineering in the Technical University of Ostrava. The 15th International Conference on Biomedical Engineering, pp. 531–534. Springer International Publishing (2014)

    Google Scholar 

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Acknowledgements

The work and the contributions were supported by the project SP2015/179 ‘Biomedicínské inženýrské systémy XI’ and This work is partially supported by the Science and Research Fund 2014 of the Moravia-Silesian Region, Czech Republic and this paper has been elaborated in the framework of the project “Support research and development in the Moravian-Silesian Region 2014 DT 1—Research Teams” (RRC/07/2014). Financed from the budget of the Moravian-Silesian Region.

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Correspondence to Martin Augustynek .

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Augustynek, M., Zemanova, A., Kubicek, J., Penhaker, M. (2016). Model of Drugs Penetration Through Biological Membrane. In: Sulaiman, H., Othman, M., Othman, M., Rahim, Y., Pee, N. (eds) Advanced Computer and Communication Engineering Technology. Lecture Notes in Electrical Engineering, vol 362. Springer, Cham. https://doi.org/10.1007/978-3-319-24584-3_41

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  • DOI: https://doi.org/10.1007/978-3-319-24584-3_41

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-24582-9

  • Online ISBN: 978-3-319-24584-3

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