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Connective Tissue Disease pp 239–261Cite as

Innovative Therapies in Systemic Lupus Erythematosus

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Part of the book series: Rare Diseases of the Immune System ((RDIS))

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune condition with unpredictable course, with periods of flares and remission. SLE is characterized by a broad spectrum of clinical manifestations and varying patterns of disease activity. The efficacy of current SLE medication has been questioned by treatment-related adverse side effects secondary to corticosteroid use and untargeted immunosuppression and by the increasing number of patients with refractory disease. Over the last decades, there has been major progress in the understanding of the immunopathology of SLE, paving the way for the development of new biological agents, potentially revolutionizing the treatment of SLE. A variety of novel therapeutic targets have been identified and there have been many studies in patients with SLE in an attempt to translate these new treatments into clinical practice.

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Authors and Affiliations

  1. SCDU Nephrology and Dialysis, Giovanni Bosco Hospital, Piazza del donatore di Sangue 3, Turin, 10154, Italy

    Roberta Fenoglio & Dario Roccatello

  2. Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA

    Fernando Fervenza

  3. Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Center of Research of Immunopathology and Rare Diseases – Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Giovanni Bosco Hospital, University of Turin, Piazza del donatore di Sangue 3, Turin, 10154, Italy

    Dario Roccatello

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Correspondence to Fernando Fervenza .

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  1. Giovanni Bosco Hospital, Center of Immunopathology/Rare Dise, Torino, Torino, Italy

    Dario Roccatello

  2. University of Florence, Florence, Italy

    Lorenzo Emmi

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Fenoglio, R., Fervenza, F., Roccatello, D. (2016). Innovative Therapies in Systemic Lupus Erythematosus. In: Roccatello, D., Emmi, L. (eds) Connective Tissue Disease. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-24535-5_17

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